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Nano-confined photonic system for detection of breast cancer spread to the lymph nodes

Objective

The Vision of HypoSens is to develop a widely accepted,non-invasive and crucial prognostic tool for breast cancer progression in early stages to help clinicians and specially oncologists to decide about prompt therapy approaches to patients and improve quality of life and expectancy. Our breakthrough research will focus on the development, pre-clinical and clinical validation, and industrial demonstration of a unique all optical cancer prognostic system that will determine presence of cancer cells in the breast lymph nodes and characterize them, which correlates with presence of metastasis and bad prognosis. HypoSens prognostic system will consist of a non-invasive Near-infrared imaging device able to register signals through scattering media enabled by the implementation of wavefront shaping,that will process data collected by injected tumour-targeted body antibody functionalised nano-particles containing porphyrin sensors that will determine local oxygen concentration and local temperature distribution in the cancer cells.The HypoSens imaging system is strategically designed to offer a non-invasive alternative to the Sentinel Lymph Node Biopsy,the current surgical procedure for breast cancer staging. With an approximate cost of 60,000€ per device unit and additional 5,000€ per patient, the device is an affordable, accurate, easy to use prognostic solution for clinicians towards more accurate and fast diagnostics and personalised treatment options.The initial target of the project is metastatic breast cancer, with potential later involvement in other cancer markets, e.g. vulval, renal, colorectal, gastric etc (via the use of different tumor-targeting moiety).With an estimated 1.7 million new cases each year, breast cancer is the most common cancer among women worldwide.Its low cost will enable a wide and fast take-up by clinicians and hospitals leading to an important reduction of the economic and societal burden related to the diagnosis and treatment of cancer.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology
  • /medical and health sciences/clinical medicine/surgery/surgical procedure
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer

Call for proposal

H2020-ICT-2016-1
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

ACONDICIONAMIENTO TARRASENSE ASSOCIACION
Address
Carrer De La Innovacio 2
08225 Terrassa
Spain
Activity type
Research Organisations
EU contribution
€ 672 083,75

Participants (10)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 490 981,25
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
FUNDACION RIOJA SALUD-FRS
Spain
EU contribution
€ 407 677,50
Address
Calle Piqueras 98
26006 Logrono
Activity type
Research Organisations
SOFIA UNIVERSITY ST KLIMENT OHRIDSKI
Bulgaria
EU contribution
€ 403 162,50
Address
Bul Tzar Osvoboditel 15
1504 Sofia
Activity type
Higher or Secondary Education Establishments
TECNOLOGIAS AVANZADAS INSPIRALIA SL

Participation ended

Spain
EU contribution
€ 83 551
Address
Calle Miguel Villanueva 2 6 Piso Puerta 3
26001 Logrono
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
EU contribution
€ 539 041,25
Address
Senate Building Technion City
32000 Haifa
Activity type
Higher or Secondary Education Establishments
BCB Informatica y Control S.L.
Spain
EU contribution
€ 372 500
Address
Calle Fernando El Catolico 11/2B Dcha
28015 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OBELIS SA
Belgium
EU contribution
€ 319 200
Address
Boulevard General Wahis 53
1030 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KNOWLEDGE INNOVATION MARKET S.L.
Spain
EU contribution
€ 240 250
Address
Calle Venezuela 103 Planta 1 Puerta
08019 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UFO
Albania
EU contribution
€ 193 750
Address
Bulevardi Zogu I, Building 2
1000 Tirana
Activity type
Higher or Secondary Education Establishments
FUNDACION PARA EL DESARROLLO Y LA INNOVACION TECNOLOGICA
Spain
EU contribution
€ 276 449
Address
Paseo Castellana Num 141 Planta 18 Edificio Cuzco Iv
28046 Madrid
Activity type
Other