CORDIS
Risultati della ricerca dell’UE

CORDIS

Italiano IT
All-optical brain-to-brain behaviour and information transfer

All-optical brain-to-brain behaviour and information transfer

Obiettivo

Exchange of information between different brains usually takes place through the interaction between bodies and the external environment. The ultimate goal of this project is to establish a novel paradigm of brain-to-brain communication based on direct full-optical recording and controlled stimulation of neuronal activity in different subjects. To pursue this challenging objective, we propose to develop optical technologies well beyond the state of the art for simultaneous neuronal “reading” and “writing” across large volumes and with high spatial and temporal resolution, targeted to the transfer of advantageous behaviour in physiological and pathological conditions.
We will perform whole-brain high-resolution imaging in zebrafish larvae to disentangle the activity patterns related to different tasks. We will then use these patterns as stimulation templates in other larvae to investigate spatio-temporal subject-invariant signatures of specific behavioural states. This ‘pump and probe’ strategy will allow gaining deep insights into the complex relationship between neuronal activity and subject behaviour.
To move towards clinics-oriented studies on brain stimulation therapies, we will complement whole-brain experiments in zebrafish with large area functional imaging and optostimulation in mammals. We will investigate all-optical brain-to-brain information transfer to boost an advantageous behaviour, i.e. motor recovery, in a mouse model of stroke. Mice showing more effective responses to rehabilitation will provide neuronal activity templates to be elicited in other animals, in order to increase rehabilitation efficiency.
We strongly believe that the implementation of new technologies for all-optical transfer of behaviour between different subjects will offer unprecedented views of neuronal activity in healthy and injured brain, paving the way to more effective brain stimulation therapies.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Istituzione ospitante

UNIVERSITA DEGLI STUDI DI FIRENZE

Indirizzo

Piazza San Marco 4
50121 Florence

Italia

Tipo di attività

Higher or Secondary Education Establishments

Contributo UE

€ 1 900 000

Beneficiari (3)

Classifica in ordine alfabetico

Classifica per Contributo UE

Espandi tutto

UNIVERSITA DEGLI STUDI DI FIRENZE

Italia

Contributo UE

€ 1 900 000

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Italia

Contributo UE

€ 233 000

CONSIGLIO NAZIONALE DELLE RICERCHE

Italia

Contributo UE

€ 237 250

Informazioni relative al progetto

ID dell’accordo di sovvenzione: 692943

Stato

Progetto in corso

  • Data di avvio

    1 Dicembre 2016

  • Data di completamento

    30 Novembre 2021

Finanziato da:

H2020-EU.1.1.

  • Bilancio complessivo:

    € 2 370 250

  • Contributo UE

    € 2 370 250

Ospitato da:

UNIVERSITA DEGLI STUDI DI FIRENZE

Italia