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Multimodal highly-sensitive PhotonICs endoscope for improved in-vivo COLOn Cancer diagnosis and clinical decision support

Multimodal highly-sensitive PhotonICs endoscope for improved in-vivo COLOn Cancer diagnosis and clinical decision support

Objective

Colorectal cancer represents around one tenth of all cancers worldwide. Early and accurate diagnosis and precise intervention can increase cure rate up to 90%. Improved diagnostic techniques with enough sensitivity and specificity are required to allow in situ assessment, safe characterization and resection of lesions during clinical practice interventions.
The multidisciplinary PICCOLO team proposes a new compact, hybrid and multimodal photonics endoscope based on Optical Coherence Tomography (OCT) and Multi-Photon Tomography (MPT) combined with novel red-flag fluorescence technology for in vivo diagnosis and clinical decision support. By combining the outstanding structural information from OCT with the precise functional information from MPT, this innovative endoscope will provide gastroenterologists immediate and detailed in situ identification of colorectal neoplastic lesions and facilitate accurate and reliable in vivo diagnostics, with additional, grading capabilities for colon cancer as well as in-situ lesion infiltration and margin assessment. With the development of compact instrumentation, the cost of the components and thus the system will be significantly reduced. Human representative animal models will be used to generate imaging biomarkers that allow automated detection, assessment and grading of disease. The developed system will be tested in operating room conditions.

The consortium comprises the whole value chain including pre-clinical and clinical partners, technology providers, photonics SMEs and endoscopy market leader company. The project will permit these companies to enhance their competitiveness and leadership in the diagnostics sector as well as exploiting new market opportunities. The new endoscope will significantly impact clinical practice allowing in vivo optical biopsy assessment via the automatic analysis of images allowing accurate and efficient characterisation of colorectal lesions.
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Coordinator

FUNDACION TECNALIA RESEARCH & INNOVATION

Address

Parque Cientifico Y Tecnologico De Bizkaia, Astondo Bidea, Edificio 700
48160 Derio Bizkaia

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 665 587,50

Participants (8)

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KARL STORZ GMBH & CO. KG

Germany

EU Contribution

€ 492 500

L4T-LIGHT4TECH SRL

Italy

EU Contribution

€ 501 250

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

Ireland

EU Contribution

€ 499 250

M-SQUARED LASERS LIMITED

United Kingdom

EU Contribution

€ 358 750

LABORATORIO EUROPEO DI SPETTROSCOPIE NON LINEARI

Italy

EU Contribution

€ 361 500

FUNDACION CENTRO DE CIRUGIA DE MINIMA INVASION JESUS USON

Spain

EU Contribution

€ 440 450

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 358 242,50

FUNDACION VASCA DE INNOVACION E INVESTIGACION SANITARIAS

Spain

EU Contribution

€ 320 125

Project information

Grant agreement ID: 732111

Status

Ongoing project

  • Start date

    1 January 2017

  • End date

    30 June 2020

Funded under:

H2020-EU.2.1.1.

  • Overall budget:

    € 3 997 655

  • EU contribution

    € 3 997 655

Coordinated by:

FUNDACION TECNALIA RESEARCH & INNOVATION

Spain