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Multimodal highly-sensitive PhotonICs endoscope for improved in-vivo COLOn Cancer diagnosis and clinical decision support

Objective

Colorectal cancer represents around one tenth of all cancers worldwide. Early and accurate diagnosis and precise intervention can increase cure rate up to 90%. Improved diagnostic techniques with enough sensitivity and specificity are required to allow in situ assessment, safe characterization and resection of lesions during clinical practice interventions.
The multidisciplinary PICCOLO team proposes a new compact, hybrid and multimodal photonics endoscope based on Optical Coherence Tomography (OCT) and Multi-Photon Tomography (MPT) combined with novel red-flag fluorescence technology for in vivo diagnosis and clinical decision support. By combining the outstanding structural information from OCT with the precise functional information from MPT, this innovative endoscope will provide gastroenterologists immediate and detailed in situ identification of colorectal neoplastic lesions and facilitate accurate and reliable in vivo diagnostics, with additional, grading capabilities for colon cancer as well as in-situ lesion infiltration and margin assessment. With the development of compact instrumentation, the cost of the components and thus the system will be significantly reduced. Human representative animal models will be used to generate imaging biomarkers that allow automated detection, assessment and grading of disease. The developed system will be tested in operating room conditions.

The consortium comprises the whole value chain including pre-clinical and clinical partners, technology providers, photonics SMEs and endoscopy market leader company. The project will permit these companies to enhance their competitiveness and leadership in the diagnostics sector as well as exploiting new market opportunities. The new endoscope will significantly impact clinical practice allowing in vivo optical biopsy assessment via the automatic analysis of images allowing accurate and efficient characterisation of colorectal lesions.

Field of science

  • /medical and health sciences/clinical medicine/cancer/colorectal cancer
  • /natural sciences/physical sciences/optics/laser physics
  • /natural sciences/computer and information sciences/software
  • /natural sciences/computer and information sciences/databases
  • /social sciences/economics and business/business and management/commerce

Call for proposal

H2020-ICT-2016-1
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

FUNDACION TECNALIA RESEARCH & INNOVATION
Address
Parque Cientifico Y Tecnologico De Gipuzkoa Paseo Mikeletegi 2
20009 Donostia/san Sebastian (Gipuzkoa)
Spain
Activity type
Research Organisations
EU contribution
€ 683 500

Participants (8)

KARL STORZ SE & CO. KG
Germany
EU contribution
€ 492 500
Address
Dr.-karl-storz-strasse 34
78532 Tuttlingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
L4T-LIGHT4TECH SRL
Italy
EU contribution
€ 501 250
Address
Via Della Cernaia 5
50129 Firenze
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
EU contribution
€ 481 337,50
Address
Western Road
T12 YN60 Cork
Activity type
Higher or Secondary Education Establishments
M-SQUARED LASERS LIMITED
United Kingdom
EU contribution
€ 358 750
Address
Venture Building 1 Kelvin Campus Maryhill Road West Of Scotland Science Park
G20 0SP Glasgow
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LABORATORIO EUROPEO DI SPETTROSCOPIE NON LINEARI
Italy
EU contribution
€ 361 500
Address
Via Nello Carrara 1
50019 Sesto-fiorentino (Fi)
Activity type
Research Organisations
FUNDACION CENTRO DE CIRUGIA DE MINIMA INVASION JESUS USON
Spain
EU contribution
€ 440 450
Address
Carretera Nacional 521 Km 41 8
10071 Caceres
Activity type
Research Organisations
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 358 242,50
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
FUNDACION VASCA DE INNOVACION E INVESTIGACION SANITARIAS
Spain
EU contribution
€ 320 125
Address
Ronda De Azkue,1
48902 Barakaldo
Activity type
Research Organisations