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Solid Catalysts for activation of aromatic C-H bonds

Objective

Objectives
The H-CCAT project designs, upscales and shapes hybrid catalysts for the C-H functionalization of aromatic compounds. These solid catalysts will possess better recoverability, higher turnover numbers and better selectivity than current homogeneous catalysts for these reactions. The solid catalysts are applied at demonstration scale in the step-economical production of arylated or alkenylated aromatics, yielding motifs of active pharmaceutical ingredients.
Methodology
We will design heterogeneous hybrid catalysts featuring deactivation-resistant active sites, based on N-heterocyclic carbenes (NHCs) or diimine ligands and active metal ions. Via efficient, one-step protocols based on self-assembly, these sites will be embedded in robust porous hybrid materials like hybrid silica or metal-organic frameworks. Deactivation or metal aggregation will be prevented by site isolation or by efficient metal reoxidation (for the oxidative alkenylations). Metal leaching is precluded by using strong bonds between metals and embedded ligands like NHCs. Flow protocols will be designed to maximize the turnover numbers. Catalyst synthesis will be scaled up to kg scale, using efficient one-step protocols, minimizing use of solvents or waste formation. Soft shaping methods, e.g. spray drying, will preserve porosity and activity of the hybrid solids. A demonstration is conducted at minipilot scale at the J&J site (Belgium), allowing LCA analysis, techno-economic assessment and elaboration of the business plan.
Relevance to work program
The catalysts feature new, deactivation resistant active sites; their TOF/TON is maximized by an appropriate porous structure which even can be swelling. Catalysts are produced using innovative one-step protocols to form porous hybrid catalysts as powders or even immediately as shaped objects. The molecules targeted have strong biological and pharmaceutical relevance; they target diseases like influenza, cancer or HIV (case study: Rilpivirine).

Field of science

  • /natural sciences/chemical sciences/organic chemistry/aromatic compounds

Call for proposal

H2020-NMBP-2016-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Address
Oude Markt 13
3000 Leuven
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 547 600

Participants (9)

UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
EU contribution
€ 502 075
Address
Piazza Dell Universita 1
06123 Perugia
Activity type
Higher or Secondary Education Establishments
GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS
Germany
EU contribution
€ 508 750
Address
Wilhelmsplatz 1
37073 Gottingen
Activity type
Higher or Secondary Education Establishments
AXEL'ONE
France
EU contribution
€ 436 517,50
Address
Rond Point Echangeur Solaize
69360 Solaize
Activity type
Research Organisations
JOHNSON MATTHEY PLC
United Kingdom
EU contribution
€ 520 667,50
Address
Farringdon Street 25 5Th Floor
EC4A 4AB London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 499 956,25
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
JANSSEN PHARMACEUTICA NV
Belgium
EU contribution
€ 1 019 475
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 1 580 493,75
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
SIKEMIA
France
EU contribution
€ 404 375
Address
Place Eugene Bataillon Campus
34095 Montpellier Cedex 5
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PROFMOF AS
Norway
EU contribution
€ 568 402,50
Address
Kirkegardsvein 45
3616 Kongsberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)