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Solid Catalysts for activation of aromatic C-H bonds

Objective

Objectives
The H-CCAT project designs, upscales and shapes hybrid catalysts for the C-H functionalization of aromatic compounds. These solid catalysts will possess better recoverability, higher turnover numbers and better selectivity than current homogeneous catalysts for these reactions. The solid catalysts are applied at demonstration scale in the step-economical production of arylated or alkenylated aromatics, yielding motifs of active pharmaceutical ingredients.
Methodology
We will design heterogeneous hybrid catalysts featuring deactivation-resistant active sites, based on N-heterocyclic carbenes (NHCs) or diimine ligands and active metal ions. Via efficient, one-step protocols based on self-assembly, these sites will be embedded in robust porous hybrid materials like hybrid silica or metal-organic frameworks. Deactivation or metal aggregation will be prevented by site isolation or by efficient metal reoxidation (for the oxidative alkenylations). Metal leaching is precluded by using strong bonds between metals and embedded ligands like NHCs. Flow protocols will be designed to maximize the turnover numbers. Catalyst synthesis will be scaled up to kg scale, using efficient one-step protocols, minimizing use of solvents or waste formation. Soft shaping methods, e.g. spray drying, will preserve porosity and activity of the hybrid solids. A demonstration is conducted at minipilot scale at the J&J site (Belgium), allowing LCA analysis, techno-economic assessment and elaboration of the business plan.
Relevance to work program
The catalysts feature new, deactivation resistant active sites; their TOF/TON is maximized by an appropriate porous structure which even can be swelling. Catalysts are produced using innovative one-step protocols to form porous hybrid catalysts as powders or even immediately as shaped objects. The molecules targeted have strong biological and pharmaceutical relevance; they target diseases like influenza, cancer or HIV (case study: Rilpivirine).

Call for proposal

H2020-NMBP-2016-2017

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Sub call

H2020-NMBP-2016-two-stage

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Net EU contribution
€ 1 538 618,90
Address
Oude Markt 13
3000 Leuven
Belgium

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (10)

UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
Net EU contribution
€ 511 056,10
Address
Piazza Dell Universita 1
06123 Perugia

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Region
Centro (IT) Umbria Perugia
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS
Germany
Net EU contribution
€ 508 750,00
Address
Wilhelmsplatz 1
37073 Gottingen

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Region
Niedersachsen Braunschweig Göttingen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AXEL'ONE
France
Net EU contribution
€ 436 517,50
Address
Rond Point Echangeur Solaize
69360 Solaize

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Research Organisations
Non-EU contribution
€ 0,00
JOHNSON MATTHEY PLC
United Kingdom
Net EU contribution
€ 520 667,50
Address
Farringdon Street 25 5Th Floor
EC4A 4AB London

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Region
London Inner London — West Camden and City of London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 499 956,25
Address
Hansastrasse 27C
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00
JANSSEN PHARMACEUTICA NV
Belgium
Net EU contribution
€ 1 019 475,00
Address
Turnhoutseweg 30
2340 Beerse

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Region
Vlaams Gewest Prov. Antwerpen Arr. Turnhout
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 1 490 715,09
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITE DE MONTPELLIER
France
Net EU contribution
€ 89 778,66
Address
163 Rue Auguste Broussonnet
34090 Montpellier

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Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SIKEMIA
France
Net EU contribution
€ 404 375,00
Address
Cap Gamma Zac Euromedecine Ii 1682 Rue De La Valsiere
34790 Grabels

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
PROFMOF AS
Norway
Net EU contribution
€ 568 402,50
Address
Kirkegardsvein 45
3616 Kongsberg

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Region
Norge Oslo og Viken Viken
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00