Objective
The npSCOPE project aims at developing a new integrated instrument (the nanoparticle-scope) optimised for providing a complete physico-chemical characterisation of nanoparticles both in their pristine form or embedded in complex matrices such as biological tissues. Using sophisticated correlative data processing methodologies and algorithms based on statistical methods in conjunction with appropriate visualisation methods of the results, the npSCOPE instrument will allow rapid, accurate and reproducible measurements.
The instrument will be based on the Gas Field Ion Source as a key enabling technology, which we will combine with a number of new developments in the field of electron and ion microscopy. We will progressively ramp up the TRL of the instrument and associated methodologies to reach TRL 7 by the end of the project. The new technology, and all related processes and methodologies, will be validated via round-robin studies performed independently by several partner institutions, crosschecked with conventional analysis technologies to demonstrate the advancements and capabilities of the npSCOPE technology and benchmarked in representative case studies. Given the low sample quantities needed and the strong potential of the instrument to generate high-quality physico-chemical data on nanomaterials, both ex situ and in situ, npSCOPE will allow a major step forward in defining key descriptors for read-across, grouping, in silico modelling and creating meaningful relationships with biological activity data for QSAR purposes.
To reach these objectives, the project consortium will be composed of research centres internationally recognised for innovative instrument developments, well-established instrument manufacturers and experts in nanotoxicology in various fields of application to demonstrate and validate the applicability of npSCOPE for the risk assessment of nanomaterials in consumer products.
Field of science
- /engineering and technology/environmental engineering/energy and fuels/fossil energy/natural gas
- /natural sciences/physical sciences/optics/microscopy
- /engineering and technology/nanotechnology/nano-materials
- /natural sciences/computer and information sciences/software
- /natural sciences/computer and information sciences/data science/data processing
- /natural sciences/chemical sciences/analytical chemistry/mass spectrometry
Programme(s)
Call for proposal
H2020-NMBP-2016-two-stage
See other projects for this call
Funding Scheme
RIA - Research and Innovation actionCoordinator
4362 Esch Sur Alzette
Luxembourg
Participants (8)
07745 Jena
01328 Dresden
9301 ZR Roden
8092 Zuerich
91054 Erlangen
2400 Mol
66802 Uberherrn
75007 Paris Cedex 07
