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OpenRiskNet: Open e-Infrastructure to Support Data Sharing, Knowledge Integration and in silico Analysis and Modelling in Risk Assessment

Objective

Toxicology and risk assessment are undergoing a paradigm shift, from a phenomenological to a mechanistic discipline based on in vitro and in silico approaches that represent an important alternative to classical animal testing applied to the evaluation of chronic and systemic toxicity risks. Large databases and highly sophisticated methods, algorithms and tools are available for different tasks such as hazard prediction, toxicokinetics, and in vitro – in vivo extrapolations to support this transition. However, since these services are developed independently and provided by different groups world-wide, there is no standardized way how to access the data or run modelling workflows. To overcome the fragmentation of data and tools, OpenRiskNet will provide open e-Infrastructure resources and services to a variety of communities requiring chemical risk assessment, including chemicals, cosmetic ingredients, therapeutic agents, and nanomaterials. OpenRiskNet will combine the achievements from earlier projects for generating modeling and validation workflows, knowledge integration and data management as well as include all ongoing projects and important stakeholders through an associated partner programme. The main components of the infrastructure will be an interoperability layer added to every service to describe the functionality and guaranteeing technical and semantic interoperability, a discovery service, deployment options based on container technology, and packaging of the infrastructure into virtual instances. This will be complemented by training and support on integration of specific services based on prototype implementation, usage of standard file formats for data sharing including the generation of templates for data and metadata, as well as the harmonized usage of ontologies. Case studies will demonstrate the applicability of the infrastructure in productive settings supporting research and innovation in safer product design and risk assessment.

Coordinator

EDELWEISS CONNECT GMBH

Address

Hochbergerstrasse 60c
4057 Basel

Switzerland

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU Contribution

€ 621 875

Participants (11)

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JOHANNES GUTENBERG-UNIVERSITAT MAINZ

Germany

EU Contribution

€ 290 000

FUNDACIO CENTRE DE REGULACIO GENOMICA

Spain

EU Contribution

€ 181 875

UNIVERSITEIT MAASTRICHT

Netherlands

EU Contribution

€ 460 250

THE UNIVERSITY OF BIRMINGHAM

United Kingdom

EU Contribution

€ 243 500

NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA

Greece

EU Contribution

€ 180 500

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU Contribution

€ 149 137,50

UPPSALA UNIVERSITET

Sweden

EU Contribution

€ 309 500

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Austria

INFORMATICS MATTERS LIMITED

United Kingdom

EU Contribution

€ 318 750

INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS

France

EU Contribution

€ 116 250

STICHTING VU

Netherlands

EU Contribution

€ 127 475

Project information

Grant agreement ID: 731075

Status

Ongoing project

  • Start date

    1 December 2016

  • End date

    30 November 2019

Funded under:

H2020-EU.1.4.1.3.

  • Overall budget:

    € 2 999 112,50

  • EU contribution

    € 2 999 112,50

Coordinated by:

EDELWEISS CONNECT GMBH

Switzerland