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OpenRiskNet: Open e-Infrastructure to Support Data Sharing, Knowledge Integration and in silico Analysis and Modelling in Risk Assessment

Objective

Toxicology and risk assessment are undergoing a paradigm shift, from a phenomenological to a mechanistic discipline based on in vitro and in silico approaches that represent an important alternative to classical animal testing applied to the evaluation of chronic and systemic toxicity risks. Large databases and highly sophisticated methods, algorithms and tools are available for different tasks such as hazard prediction, toxicokinetics, and in vitro – in vivo extrapolations to support this transition. However, since these services are developed independently and provided by different groups world-wide, there is no standardized way how to access the data or run modelling workflows. To overcome the fragmentation of data and tools, OpenRiskNet will provide open e-Infrastructure resources and services to a variety of communities requiring chemical risk assessment, including chemicals, cosmetic ingredients, therapeutic agents, and nanomaterials. OpenRiskNet will combine the achievements from earlier projects for generating modeling and validation workflows, knowledge integration and data management as well as include all ongoing projects and important stakeholders through an associated partner programme. The main components of the infrastructure will be an interoperability layer added to every service to describe the functionality and guaranteeing technical and semantic interoperability, a discovery service, deployment options based on container technology, and packaging of the infrastructure into virtual instances. This will be complemented by training and support on integration of specific services based on prototype implementation, usage of standard file formats for data sharing including the generation of templates for data and metadata, as well as the harmonized usage of ontologies. Case studies will demonstrate the applicability of the infrastructure in productive settings supporting research and innovation in safer product design and risk assessment.

Call for proposal

H2020-EINFRA-2016-1
See other projects for this call

Coordinator

EDELWEISS CONNECT GMBH
Address
Hochbergerstrasse 60C
4057 Basel
Switzerland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 621 875

Participants (10)

JOHANNES GUTENBERG-UNIVERSITAT MAINZ
Germany
EU contribution
€ 290 000
Address
Saarstrasse 21
55122 Mainz
Activity type
Higher or Secondary Education Establishments
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 181 875
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 460 250
Address
Minderbroedersberg 4
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 243 500
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA
Greece
EU contribution
€ 180 500
Address
Heroon Polytechniou 9 Zographou Campus
15780 Athina
Activity type
Higher or Secondary Education Establishments
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 149 137,50
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 309 500
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 127 475
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
INFORMATICS MATTERS LIMITED
United Kingdom
EU contribution
€ 318 750
Address
Yew Tree Farm, High Street, Charlton On Otmoor
OX5 2UQ Kidlington
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS
France
EU contribution
€ 116 250
Address
Parc Technologique Alata
60550 Verneuil En Halatte
Activity type
Research Organisations