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ZIKAction: Preparedness, research and action network on maternal-paediatric axis of ZIKV infection in Latin America and the Caribbean

Fact Sheet

Reporting

Results

Objective

ZIKAction proposes to set up a multidisciplinary research network across Latin America with a focus on maternal and child health to coordinate and implement urgent research against the current ZIKV outbreak and lay the foundation for a preparedness research network against future emerging severe infectious threats in these vulnerable populations. Our Consortium brings together Latin American and European leaders in paediatric infectious disease research, including virologists, epidemiologists, immunologists and obstetric, neonatal and paediatric practitioners, all with a wealth of experience in vertical transmission (VT) studies, a group uniquely placed to evaluate the potentially causative relationship between ZIKV and severe reported complications. ZIKAction will collect data from prospective cohorts of pregnant women and infants to assess ZIKV complications with the necessary level of evidence which is currently lacking. Complementary work in virology will take advantage of repeated biological samples from these cohorts, while pathogenesis studies on animal models will elucidate risk factors and mechanisms of VT. Partners’ experience in conducting trials among pregnant women and children and close contact with other relevant researchers will allow rapid launch of additional interventional studies, including the addition of sites and partners, to address remaining research gaps against ZIKV. Recognizing the breadth and complexity of the research questions presented by the current ZIKV epidemic and the potential for future severe emerging infectious threats, ZIKAction will actively seek out collaborations with relevant initiatives already existing or under development to maximize synergy and avoid duplication of efforts. Our focus on vertical transmission and maternal and child health would nicely complement a range of other activities including clinical and laboratory studies in the general population, surveillance, and work in public health and prevention.

Programme(s)

H2020-EU.3.1.3. - Treating and managing disease

Topic(s)

SC1-PM-22-2016 - Addressing the urgent research gaps against the Zika virus and other emerging threats in Latin America

Call for proposal

H2020-SC1-2016-RTD-Zika

See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

FONDAZIONE PENTA - FOR THE TREATMENT AND CARE OF CHILDREN WITH HIV ANDRELATED DISEASES - ONLUS

Address

Corso Stati Uniti 4
35127 Padova

Italy

Activity type

Research Organisations

EU Contribution

€ 620 807,70

Website

Contact the organisation

Participants (13)

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UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 719 316,25

SERVIZO GALEGO DE SAUDE

Spain

EU Contribution

€ 545 483,75

THE UNIVERSITY OF THE WEST INDIES U WI*

Jamaica

EU Contribution

€ 877 065

ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLE VENEZIE

Italy

EU Contribution

€ 453 485

HOSPITAL DE PEDIATRIA SAMIC PROF. DR. JUAN P. GARRAHAN

Argentina

EU Contribution

€ 152 153,75

UNIVERSITY OF BRISTOL

United Kingdom

EU Contribution

€ 195 126,25

FUNDACAO OSWALDO CRUZ

Brazil

EU Contribution

€ 463 995

University of Florida

United States

EU Contribution

€ 881 793

IRMANDADE DA SANTA CASA DE MISERICORDIA DE SAO PAULO

Brazil

EU Contribution

€ 813 254,75

SECRETARIA DE SAUDE DO ESTADO CEARA

Brazil

EU Contribution

€ 394 480

INSTITUT CATALA DE LA SALUT

Spain

EU Contribution

€ 302 446,75

CENTRO HOSPITALAR E UNIVERSITARIO DE COIMBRA E.P.E.

Portugal

EU Contribution

€ 281 993,75

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 214 680,30

Project information

ZIKAction

Grant agreement ID: 734857

Project website

Status

Ongoing project

Start date

1 October 2016
End date

30 September 2021

Funded under:

H2020-EU.3.1.3.

Overall budget:

€ 6 916 081,25
EU contribution

€ 6 916 081,25

Coordinated by:

FONDAZIONE PENTA - FOR THE TREATMENT AND CARE OF CHILDREN WITH HIV ANDRELATED DISEASES - ONLUS

Italy

Periodic Reporting for period 1 - ZIKAction (ZIKAction: Preparedness, research and action network on maternal-paediatric axis of ZIKV infection in Latin America and the Caribbean)

Reporting period: 2016-10-01 to 2018-03-31

Summary of the context and overall objectives of the project

The ZIKAction project was designed to address key knowledge gaps related to ZIKV epidemiology, natural history and pathogenesis with particular emphasis on maternal and child health. This research is important for society because, while sufficient evidence exists to infer a causal relationship between prenatal ZIKV infection and microcephaly and other severe brain anomalies, much remains to be elucidated regarding the natural history of ZIKV infection in pregnancy and childhood and the medium and long term sequelae of exposure to ZIKV in utero.
The first objective includes a prospective cohort studies in ZIKV-affected countries in LA and the Caribbean to assess pregnancy and fetal/infant outcomes of ZIKV in pregnancy, the risk of vertical transmission by gestational age, and the incidence of ZIKV in pregnancy and during the postnatal period in epidemic situations. This information will inform the second objective of the project to develop harmonized case definitions for congenital ZIKV infection and define its natural history through a registry of paediatric patients exposed to ZIKV in utero and/or presenting with symptoms of congenital ZIKV syndrome. The third objective is to use animal models to better understand the timing and mechanisms of ZIKV vertical transmission and to assess the causal role of ZIKV infection during pregnancy on fetal malformation and other adverse pregnancy outcomes with the use of ovine models. Human placental explants are also being used to better understand how the Zika virus interacts with placental tissues and identify factors influencing vertical transmission.
We also aim to assess laboratory diagnostics and establish clinical algorithms for rapid diagnosis of ZIKV in pregnant women, infants and children. Improved diagnostics lead to more timely and accurate information on infection, helping to avoid anxiety related to false positive test results and give more definitive results to patients and their families. A final objective of the ZIKAction project is the harmonization of activities with ZikaPLAN and ZIKAlliance.

Work performed from the beginning of the project to the end of the period covered by the report and main results achieved so far

Progress beyond the state of the art and expected potential impact (including the socio-economic impact and the wider societal implications of the project so far)

Sheep IgM ELISA for Zika virus

Project information

ZIKAction

Grant agreement ID: 734857

Project website

Status

Ongoing project

Start date

1 October 2016
End date

30 September 2021

Funded under:

H2020-EU.3.1.3.

Overall budget:

€ 6 916 081,25
EU contribution

€ 6 916 081,25

Coordinated by:

FONDAZIONE PENTA - FOR THE TREATMENT AND CARE OF CHILDREN WITH HIV ANDRELATED DISEASES - ONLUS

Deliverables

Deliverables not available

Publications

Peer reviewed articles (2)

Unravelling the Paediatric and Perinatal Zika Virus Epidemic through Population-based Research

Author(s): CDC Christie, C Giaquinto

Published in: West Indian Medical Journal, Issue Vol.65, issue 1:2016, 2017, Page(s) 239 - 242, ISSN 0043-3144

DOI: 10.7727/wimj.2016.454

Trends of Microcephaly and Severe Arthrogryposis in Three Urban Hospitals following the Zika, Chikungunya and Dengue Fever Epidemics of 2016 in Jamaica

Author(s): T James-Powell, Y Brown, CDC Christie, R Melbourne-Chambers, JT Moore, O Morgan, B Butler, K Swaby, A Garbutt, J Anzinger, RB Pierre, A Onyonyor, L Bryan, PM Palmer, P Mitchell, P Johnson, K Bishop, JR Jaggon, W De La Haye

Published in: West Indian Medical Journal, Issue Vol.66, issue 1:2017, 2017, Page(s) 10-19, ISSN 0043-3144

DOI: 10.7727/wimj.2017.124

Project information

ZIKAction

Grant agreement ID: 734857

Project website

Status

Ongoing project

Start date

1 October 2016
End date

30 September 2021

Funded under:

H2020-EU.3.1.3.

Overall budget:

€ 6 916 081,25
EU contribution

€ 6 916 081,25

Coordinated by:

FONDAZIONE PENTA - FOR THE TREATMENT AND CARE OF CHILDREN WITH HIV ANDRELATED DISEASES - ONLUS

Project information

ZIKAction

Grant agreement ID: 734857

Project website

Status

Ongoing project

Start date

1 October 2016
End date

30 September 2021

Funded under:

H2020-EU.3.1.3.

Overall budget:

€ 6 916 081,25
EU contribution

€ 6 916 081,25

Coordinated by:

FONDAZIONE PENTA - FOR THE TREATMENT AND CARE OF CHILDREN WITH HIV ANDRELATED DISEASES - ONLUS

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Last update: 6 September 2019

Record number: 206838

CORDIS

Objective

Coordinator

Participants (13)

Project information

Periodic Reporting for period 1 - ZIKAction (ZIKAction: Preparedness, research and action network on maternal-paediatric axis of ZIKV infection in Latin America and the Caribbean)

Project information

Deliverables

Publications

Project information

Project information

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