CORDIS
EU research results

CORDIS

English EN
mitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease

mitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease

Objective

"Non-Alcoholic Fatty Liver Disease (NAFLD), including its more pathologic consequence, non-alcoholic steatohepatitis (NASH), is believed to be the most common chronic liver disease worldwide, affecting between 6 to 37% of the population. NAFLD is a so called ‘silent killer’, as clinical symptoms only surface at late stages of the disease, when it is no longer treatable: untreated, NAFLD/NASH can lead to cirrhosis and hepatocellular carcinoma, culminating in liver failure. Currently the best method of diagnosing and staging the disease is liver biopsy, a costly, invasive and somewhat risky procedure, not to mention unfit for routine assessment. Besides, no therapeutic consensus exists for NAFLD/NASH treatment.
mtFOIE GRAS (Foie Gras being French for ""fat liver"") proposes to address the pressing need for non-invasive, accurate, rapid assessment of NAFLD/NASH stages, before and after intervention, through the development of biomarkers and innovative tools to follow mitochondrial (mt) dysfunction, a central mediator of fatty liver disease pathogenesis. This promising R&D strategy will also bring new knowledge about the disease mechanisms and improved understanding of the pathogenic process and disease drivers.
To that end, mtFOIE GRAS envisages a training-through-work plan that brings together an intersectoral, multidisciplinary team of researchers and technicians experts in their fields, from basic to translational research, clinical practice, technology commercialization and public advocacy. Together with several PhD students, the team will share expertises and work synergistically along the value creation chain to address the unmet medical need of more informative NAFLD assessment. In the process, mtFOIE GRAS will endow the involved staff with excellent scientific knowledge and transferable skills while building and strengthening intersectoral cooperation among partners, thus contributing to EU RD&I excellence."
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

Address

Universidade De Coimbra, Largo De Pombal
3004 517 Coimbra

Portugal

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 94 500

Participants (12)

Sort alphabetically

Sort by EU Contribution

Expand all

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 49 500

Faculdade de Farmácia da Universidade de Lisboa

Portugal

EU Contribution

€ 13 500

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

EU Contribution

€ 13 500

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 13 500

UNIVERSITA DEGLI STUDI DI BARI ALDO MORO

Italy

EU Contribution

€ 54 000

UNIVERSIDADE DO PORTO

Portugal

EU Contribution

€ 36 000

INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK

Poland

EU Contribution

€ 13 500

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 40 500

MEDIAGNOST GESELLSCHAFT FUR FORSCHUNG UND HERSTELLUNG VON DIAGNOSTIKA GMBH

Germany

EU Contribution

€ 40 500

ASSOCIACAO PROTECTORA DOS DIABETICOS DE PORTUGAL

Portugal

EU Contribution

€ 63 000

OROBOROS INSTRUMENTS GmbH

Austria

EU Contribution

€ 13 500

MICRO-BIOLYTICS GMBH

Germany

EU Contribution

€ 9 000

Project information

Grant agreement ID: 734719

Status

Ongoing project

  • Start date

    1 June 2017

  • End date

    31 May 2021

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 454 500

  • EU contribution

    € 454 500

Coordinated by:

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO

Portugal