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Blood test for clinical therapy guidance of non-small cell lung cancer patients

Objective

Lung cancer is the most common cancer worldwide. NSCLC alone make up about 75% of all lung cancers and most hospitals currently test all NSCLC patients for EGFR mutations (pharmacogenomics) for treatment decision (personalised medicine) – i.e., patients with mutation(s) in EGFR gene should receive a EGFR-Tyrosine Kinase Inhibitor (TKI) drug (e.g. afitinib) treatment; while those that do not present mutations in such gene, should be treated with chemotherapy. Currently, the laboratories use PCR and Sanger sequencing technologies to perform the EGFR analysis from tumour biopsies - Fixed Paraffin Embedded (FFPE) samples. Still, some patients (e.g., 30% in UK) may never get histological confirmation because they are too sick to make a biopsy. Furthermore, the results obtained with current methods still present low quality, mainly due to poor quality/low yield of DNA extracted from FFPE samples. The FP7 LungCARD project (www.lungcard.eu) has developed and demonstrated a LungCARD system - an automatic system composed by microfluidic chip and chip analyser - that allows to capture circulating tumour cells (CTCs) from blood samples, amplify by multiplex PCR and detect EGFR mutations, including also a software for data analysis and report. Although this new blood test has proven to be faster, cost-effective and human error-free, the detection of somatic mutations in EGFR gene at frequencies lower than 20% is still a weak point.
Therefore, the main project’s goal is to benefit from this technology, through the development, improvement, integration and validation of the LungCARD system with NGS workflow and development of a software for automatic reporting clinical results. However, LungCARD project aims to go further, by putting together a global and unique network of multidisciplinary scientists for exchange of knowledge and research training focused on non-small cell lung cancer.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /natural sciences/computer and information sciences/software
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/computer and information sciences/data science/data analysis

Call for proposal

H2020-MSCA-RISE-2016
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

STAB VIDA INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS LDA
Address
Rua Dos Inventores S/n Edificio Madan Parque Salas 2.18 E 2.19
2825 182 Caparica
Portugal
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 450 000

Participants (7)

UNIVERSITY OF HULL
United Kingdom
EU contribution
€ 180 000
Address
Cottingham Road
HU6 7RX Hull
Activity type
Higher or Secondary Education Establishments
GENOLOGICA MEDICA SL
Spain
EU contribution
€ 85 500
Address
Calle Larios 1-1 Izquierda
29000 Malaga
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT ZA ONKOLOGIJU I RADIOLOGIJU SRBIJE
Serbia
EU contribution
€ 18 000
Address
14 Pasterova St.
11000 Belgrade
Activity type
Other
GENETIKS SAGLIK HIZMETLERI TICARETLIMITED SIRKETI
Turkey
EU contribution
€ 22 500
Address
Gayrettepe Mah Bahar Sok Baras Is Merkezi No 4A Balmumlu Besiktas
34349 Istanbul
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIWERSYTET JAGIELLONSKI
Poland
EU contribution
€ 40 500
Address
Ul. Golebia 24
31007 Krakow
Activity type
Higher or Secondary Education Establishments
FUNDACAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA FP

Participation ended

Portugal
EU contribution
€ 0
Address
Campo Grande Edificio C1 Piso 3
1749 016 Lisboa
Activity type
Research Organisations
FCIENCIAS.ID - ASSOCIACAO PARA A INVESTIGACAO E DESENVOLVIMENTO DE CIENCIAS
Portugal
EU contribution
€ 180 000
Address
Campo Grande, Edificio C1, Piso 3
1749 016 Lisbon
Activity type
Research Organisations

Partners (9)

UNIVERSIDAD SAN MARTIN DE PORRES ASOCIACION
Peru
Address
Av. Las Calandrias, Santa Anita
43 Lima
Activity type
Higher or Secondary Education Establishments
Institut Pasteur Du Maroc
Morocco
Address
Place Louis Pasteur 1
20360 Casablanca
Activity type
Research Organisations
UNIVERSITE HASSAN II DE CASABLANCA
Morocco
Address
19 Rue Tarik Ibnou Ziad
20360 Casablanca
Activity type
Higher or Secondary Education Establishments
PARSEQ LAB CO LTD
Russia
Address
Birzhevaya Str 16
199034 Saint Petersburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FEDERAL UNIVERSITY OF AGRICULTURE ABEOKUTA
Nigeria
Address
Alabata Road Ogun State
110001 Abeokuta
Activity type
Higher or Secondary Education Establishments
RESPUBLIKA ONKOLOGIYA ILMIY MARKAZI
Uzbekistan
Address
Farobiy 383
100174 Taskent
Activity type
Other
UNIVERSITY OF TECHNOLOGY SYDNEY
Australia
Address
Broadway Building 1 Ultimo Nsw
2007 Sydney
Activity type
Higher or Secondary Education Establishments
Sloan-Kettering Institute for Cancer Research CORPORATION
United States
Address
York Avenue 1275
10065 New York
Activity type
Research Organisations
MILLI ONKOLOGIYA MERKEZI
Azerbaijan
Address
H. Zerdabi 79B
1122 Baku
Activity type
Research Organisations