Skip to main content

Transcranial brain stimulation as innovative therapy for chronic pediatric neuropsychiatric disorder – STIPED

Objective

Due to lack of targeted interventions, compliance issues, insufficient effect sizes and a high non-responder rate to currently available interventions, there is an urgent need to develop innovative and new interventions for chronic paediatric neuropsychiatric disorders, such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). Transcranial direct current stimulation (tDCS) has been shown to be an innovative, effective and safe alternative treatment approach for neuropsychiatric disorders in adults. Here, for the first time, the effect of tDCS on core neurocognitive and behavioral outcomes will be proven in children and adolescents. First, effect sizes and safety of standard tDCS in the clinical setting targeting core brain regions and disorder specific cognitive tasks will be established by three phase-IIa randomized, double blind, sham-controlled studies in ADHD and ASD. Second, the impact of brain development and age-dependent anatomical / functional features on effects of tDCS will be studied systematically using methods of modern neurophysiology, neuroimaging and electric current modeling. This involves an additional phase-I clinical trial. Third, mechanisms of tDCS on brain function will be studied, and biomarkers will be developed in order to predict individual response to standard and individualized stimulation protocols. Finally, the applicability of tDCS in children and adolescents will be improved by developing an innovative personalized home-based treatment option in combination with a telemental health service, which will be tested by a fifth, phase-IIa clinical trial. Throughout the entire project, ethical concerns of the target population will be addressed. This project opens a new avenue for the application of tDCS as an alternative treatment for a great number of chronic neuropsychiatric disorders in children and adolescents and will allow flexible integration of tDCS in the daily routine of families.

Call for proposal

H2020-SC1-2016-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

EVANGELISCHES KLINIKUM BETHEL GGMBH
Address
Kantensiek 11
33617 Bielefeld
Germany
Activity type
Research Organisations
EU contribution
€ 607 825

Participants (14)

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Germany
EU contribution
€ 1 141 675
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG
Germany
EU contribution
€ 375 733,75
Address
Universitaetsplatz 2
39106 Magdeburg
Activity type
Higher or Secondary Education Establishments
UNIVERSIDADE DE COIMBRA
Portugal
EU contribution
€ 495 376,25
Address
Paco Das Escolas
3001 451 Coimbra
Activity type
Higher or Secondary Education Establishments
FUNDACAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA FP

Participation ended

Portugal
EU contribution
€ 743,50
Address
Campo Grande Edificio C1 Piso 3
1749 016 Lisboa
Activity type
Research Organisations
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS
France
EU contribution
€ 184 251,25
Address
Boulevard Tonelle 2
37044 Tours Cedex 9
Activity type
Higher or Secondary Education Establishments
NEUROELECTRICS BARCELONA SL
Spain
EU contribution
€ 765 625
Address
Av. Tibidabo 47 Bis
08035 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STARLAB BARCELONA SL
Spain
EU contribution
€ 378 125
Address
Avenida Tibidabo 47 Bis
08035 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ARTTIC
France
EU contribution
€ 217 489,73
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ZENTRUM FUER INTEGRATIVE PSYHIATRIE
Germany
EU contribution
€ 262 031,25
Address
Niemannsweg 147
24105 Kiel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FCIENCIAS.ID - ASSOCIACAO PARA A INVESTIGACAO E DESENVOLVIMENTO DE CIENCIAS

Participation ended

Portugal
EU contribution
€ 629,65
Address
Campo Grande, Edificio C1, Piso 3
1749 016 Lisbon
Activity type
Research Organisations
REGION HOVEDSTADEN
Denmark
EU contribution
€ 176 435,60
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
EU contribution
€ 1 290 397
Address
Olshausenstrasse 40
24118 Kiel
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 135 883
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
ARTTIC INNOVATION GMBH
Germany
EU contribution
€ 163 010,27
Address
Oskar-von-miller-ring 29
80333 Munchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)