Skip to main content

EURopean Endeavour for Chimeric Antigen Receptor Therapies

Objective

Cancer is rapidly becoming the most frequent cause of death in EU. Though enormously expensive (several billions EUR/year), currently available anti-cancer therapies are major causes of chronic diseases. Adoptive immunotherapy with T cells genetically modified with a tumour-reactive chimeric antigen receptor (CAR) is an innovative therapeutic concept, promising to eradicate cancer without causing secondary chronic diseases. This approach is already at an advanced stage of development in the US, but struggles in the EU, due to a number of constrains that will be specifically tackled by this Project. The ultimate goal of EURE-CART is to bring EU at the forefront CAR T-cell immunotherapy. In this Project, we will extend the applicability of CAR T-cell immunotherapy to incurable tumours that have never been tackled with this approach. The EURE-CART Consortium is composed of 6 academic centres, 2 SMEs and 1 large enterprise from 6 EU countries, clearly representing excellences in their respective fields. EURE-CART will bring together clinical experts in oncology, and pioneers and leaders in the field of cell and gene therapy for starting the conduction of a first-in-man Phase I/II clinical trial. To be successful, EURE-CART proposes the early involvement of National regulatory authorities for accelerating the approval of CAR T-cell immunotherapy, as well as the centralisation of its production by the AGC Biologics (formerly Molmed SpA), which is uniquely endowed in the EU with the knowhow and experience necessary to meet this ambitious objective, as demonstrated by its unparalleled track record. The main expected impact of EURE-CART is the establishment of CAR T-cell therapy as the ultimate personalised therapy, capable of defeating chronic diseases, and to create secure new jobs in the EU through the instalment of an unprecedented alliance between academia, industry and regulatory bodies.

Call for proposal

H2020-SC1-2016-2017

See other projects for this call

Sub call

H2020-SC1-2016-RTD

Coordinator

AGC BIOLOGICS SPA
Net EU contribution
€ 2 339 697,25
Address
Via Meucci, 3
20091 Bresso Mi
Italy

See on map

Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 2 339 697,25

Participants (10)

OSPEDALE SAN RAFFAELE SRL
Italy
Net EU contribution
€ 859 375,00
Address
Via Olgettina 60
20132 Milano

See on map

Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 859 375,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
Net EU contribution
€ 163 125,00
Address
Via Olgettina 58
20132 Milano

See on map

Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Other funding
€ 163 125,00
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
Net EU contribution
€ 816 076,25
Address
Josef-schneider-strasse 2
97080 Wurzburg

See on map

Region
Bayern Unterfranken Würzburg, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 816 076,25
OSPEDALE PEDIATRICO BAMBINO GESU
Italy
Net EU contribution
€ 404 725,00
Address
Piazza Sant Onofrio 4
00165 Roma

See on map

Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Other funding
€ 404 725,00
INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU FUNDACION
Spain
Net EU contribution
€ 147 295,00
Address
C Sant Quinti 77-79
08041 Barcelona

See on map

Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 147 295,00
FAKULTNI NEMOCNICE OSTRAVA
Czechia
Net EU contribution
€ 174 852,50
Address
17 Listopadu 1790
708 52 Ostrava Poruba

See on map

Region
Moravskoslezsko Moravskoslezský kraj
Activity type
Research Organisations
Other funding
€ 174 852,50
ISTITUTO SUPERIORE DI SANITA
Italy
Net EU contribution
€ 225 000,00
Address
Viale Regina Elena 299
00161 Roma

See on map

Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Other funding
€ 225 000,00
ACROMION GMBH
Germany
Net EU contribution
€ 398 000,00
Address
Europaallee 27-29
50226 Frechen

See on map

Region
Nordrhein-Westfalen Köln Rhein-Erft-Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 398 000,00
ARTTIC
France
Net EU contribution
€ 325 912,10
Address
39 Rue Des Mathurins
75008 Paris

See on map

Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 325 912,10
ARTTIC INNOVATION GMBH
Germany
Net EU contribution
€ 49 087,90
Address
Oskar-von-miller-ring 29
80333 Munchen

See on map

Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 49 087,90