CORDIS
EU research results

CORDIS

English EN

Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine

Objective

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.

MultipleMS will therefore develop, validate, and exploit methods for patient stratification in Multiple Sclerosis, a chronic inflammatory disease and a leading causes of non-traumatic disability in young adults, with an estimated cost of €37 000 per patient per year over a duration of 30 years. Here we benefit from several large clinical cohorts with multiple data types, including genetic and lifestyle information. This in combination with publically available multi-omics maps enables us to identify biomarkers of the clinical course and the response to existing therapies in a real-world setting, and to gain in-depth knowledge of distinct pathogenic pathways setting the stage for development of new interventions.

To create strategic global synergies, MultipleMS includes 21 partners and covers not only the necessary clinical, biological, and computational expertise, but also includes six industry partners ensuring dissemination and exploitation of the methods and clinical decision support system. Moreover, the pharmaceutical industry partners provide expertise to ensure optimal selection and validation of clinically relevant biomarkers and new targets. Our conceptual personalized approach can readily be adapted to other immune-mediated diseases with a complex gene-lifestyle background and broad clinical spectrum with heterogeneity in treatment response.

MultipleMS therefore goes significantly beyond current state-of-the-art thereby broadly affecting European policies, healthcare systems, innovation in translating big data and basic research into evidence-based personalized clinical applications.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

KAROLINSKA INSTITUTET

Address

Nobels Vag 5
17177 Stockholm

Sweden

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 3 040 166,75

Participants (21)

Sort alphabetically

Sort by EU Contribution

Expand all

MABTECH AB

Sweden

EU Contribution

€ 59 000

YH YOUHEALTH AB

Sweden

EU Contribution

€ 1 263 333,75

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 1 623 011,25

BIOCOMPUTING PLATFORMS LTD OY

Finland

EU Contribution

€ 219 937,50

UNIVERSITETET I OSLO

Norway

EU Contribution

€ 547 721,25

REGION HOVEDSTADEN

Denmark

EU Contribution

€ 318 583,75

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

Germany

EU Contribution

€ 1 916 171,25

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 546 321,25

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 262 748,75

MEDIMMUNE LIMITED

United Kingdom

EU Contribution

€ 3 375

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 214 870

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 100 742,50

NEURIX SA

Switzerland

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Spain

EU Contribution

€ 301 403,75

OSPEDALE SAN RAFFAELE SRL

Italy

EU Contribution

€ 366 308,99

UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO

Italy

EU Contribution

€ 547 255

ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES

United States

EU Contribution

€ 1 497 155

KUNGLIGA TEKNISKA HOEGSKOLAN

Sweden

EU Contribution

€ 339 103,75

SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT

France

EU Contribution

€ 7 125

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

United States

EU Contribution

€ 1 278 427,50

POLICLINICO SAN DONATO SPA

Italy

EU Contribution

€ 268 691,01

Project information

Grant agreement ID: 733161

Status

Ongoing project

  • Start date

    1 January 2017

  • End date

    31 December 2021

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 15 041 259,25

  • EU contribution

    € 14 721 453

Coordinated by:

KAROLINSKA INSTITUTET

Sweden