Objetivo This H2020-FETOPEN-2016-2017 proposal initiates a major international effort to direct polymorphism in pharmaceutical compounds through crystallizing in high magnetic fields. The ability to direct polymorphism would have a transformative effect on almost all pharmaceutical compounds, and hence on society.It is proposed that MagnaPharm will drive forward innovation in pharmaceuticals by exploiting our new discovery that the polymorph and properties of carbamazepine, indomethacin and coronene can be controlled through the application of magnetic fields. We will apply our method to a range of pharmaceutical compounds, as guided by our project partner AstraZeneca, one of the largest pharmaceutical companies in the world. We will initially target 12 of the most high-profile, high-worth generic drugs with the aim of controllably synthesizing the desired polymorph of each (the lowest-energy polymorph and/or most processable form with desired properties). We aim for this goal via an international multidisciplinary approach centred around our discovery, underpinned by the development of a profound theoretical understanding of the effects of magnetic fields on organic crystal growth, that will direct the synthetic effort, all drawing on results from cutting edge spectroscopic and crystallographic characterisations.With the 12 representative generic drug molecules targeted in the initial stages of MagnaPharm responsible for €18 billion of sales per year worldwide, and the development of many new pharmaceuticals being hampered by solid form issues, control over the production of the most pharmaceutically desired crystal is a truly paradigm-shifting prospect. Ámbito científico engineering and technologymaterials engineeringcrystalsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs Programa(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Tema(s) FETOPEN-01-2016-2017 - FET-Open research and innovation actions Convocatoria de propuestas H2020-FETOPEN-2016-2017 Consulte otros proyectos de esta convocatoria Convocatoria de subcontratación H2020-FETOPEN-1-2016-2017 Régimen de financiación RIA - Research and Innovation action Coordinador UNIVERSITY OF BRISTOL Aportación neta de la UEn € 1 195 677,50 Dirección BEACON HOUSE QUEENS ROAD BS8 1QU Bristol Reino Unido Ver en el mapa Región South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 1 195 677,50 Participantes (3) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo UNIVERSITY COLLEGE LONDON Reino Unido Aportación neta de la UEn € 775 673,75 Dirección GOWER STREET WC1E 6BT London Ver en el mapa Región London Inner London — West Camden and City of London Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 775 673,75 STICHTING RADBOUD UNIVERSITEIT Países Bajos Aportación neta de la UEn € 360 031,25 Dirección HOUTLAAN 4 6525 XZ Nijmegen Ver en el mapa Región Oost-Nederland Gelderland Arnhem/Nijmegen Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 360 031,25 UNIVERSITY OF LIMERICK Irlanda Aportación neta de la UEn € 554 941,25 Dirección NATIONAL TECHNOLOGICAL PARK, PLASSEY - Limerick Ver en el mapa Región Ireland Northern and Western Border Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 554 941,25