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Towards an active bypass for neural reconnection

Towards an active bypass for neural reconnection

Objective

ByAxon is devoted to the development of a new generation of sensors and electrodes based on nanotechnology materials for neural interfacing. We aim to design and build a prototype of an active implant that could work directly at the spinal cord (SC) level. This implant will be primary focused on restoring the transmission of electrical signals in the injured SC, acting as an active local bypass, something not possible with current technology. Further applications might include deep brain stimulation or retinal implants, among others.
Current neural interfacing approaches are based on detecting electric potentials at the brain level, and/or triggering functional electrical stimulation (FES) through electrodes at muscular or SC levels. Important present drawbacks are the large number of cables and electrodes they require and, specially, the lack of sensory feedback. The ultimate non-contact sensing devices (magnetoencephalography) detect magnetic-field pulses generated by potentials at the brain, but require cryogenic temperatures, and, hence, are not portable. We will exploit here the enhanced properties of nanostructured materials to develop improved room temperature magnetoresistance-based high-resolution magnetic sensors. This will allow tackling not only the brain but also the SC directly. We pursuit a novel integrated interface comprising both sensing and stimulation at the SC level. To reach this aim, we will develop FES electrodes of enhanced adhesion and efficiency by using nanowire coatings.
ByAxon is supported by an interdisciplinary consortium, going from material scientists and electronic experts to biologists and clinicians. Our nanotechnology-based approach offers a novel perspective and will be complementary to, but independent from, present neural regenerative techniques. Our technology promises significant outcomes towards the development of an active local bypass and it has the potential to provide much-needed breakthroughs in future neuromedicine.
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Coordinator

FUNDACION IMDEA NANOCIENCIA

Address

Ciudad Universitaria De Cantoblanco - Calle Faraday 9
28049 Madrid

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 212 500

Participants (5)

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SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE

Italy

EU Contribution

€ 636 960

SERVICIO DE SALUD DE CASTILLA LA MANCHA

Spain

EU Contribution

€ 243 569,31

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 1 161 903,75

Mfd-diagnostics GmbH

Germany

EU Contribution

€ 287 500

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 209 624,44

Project information

Grant agreement ID: 737116

Status

Ongoing project

  • Start date

    1 January 2017

  • End date

    31 December 2020

Funded under:

H2020-EU.1.2.1.

  • Overall budget:

    € 3 752 057,50

  • EU contribution

    € 3 752 057,50

Coordinated by:

FUNDACION IMDEA NANOCIENCIA

Spain