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IN SITU IMAGING OF LIVING TISSUES WITH CELLULAR SPATIAL RESOLUTION

IN SITU IMAGING OF LIVING TISSUES WITH CELLULAR SPATIAL RESOLUTION

Objective

The main objective of HISTO-MRI project is to develop the technologies that will enable the non-invasive visualization of individual human cells in vivo and in real time, based on a radical new Magnetic Resonance Imaging concept: High Frequency Pulsed MRI. To accomplish this ambitious objective, several new challenging multidisciplinary technologies will have to be developed: 1) new method for the production of magnet coils, based on additive manufacturing technology, in order to stand very high currents at very high frequencies; 2) novel high frequency high voltage pulse power sources, based of semiconductor switches, to feed those magnet coils; and new pulse sequencing and computer algorithms to deal with and analyse the enormous amount of data. Therefore, this project has a foundational character, establishing the basis for a new field of research, pulsed MRI in the high frequency regime, which will radically advance MRI performance to micron resolution.
A Proof of Concept of the new technology will be accomplished through the visualization of a mouse brain at the neuron level. This new technology will enable transformative research in the fields of neurosciences, bioengineering, biophysics and experimental oncology
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Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Address

Calle Serrano 117
28006 Madrid

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 980 000

Participants (4)

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DANFYSIK AS

Denmark

EU Contribution

€ 693 750

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 250 000

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU Contribution

€ 812 500

TESORO IMAGING SL

Spain

EU Contribution

€ 480 000

Project information

Grant agreement ID: 737180

Status

Ongoing project

  • Start date

    1 January 2017

  • End date

    31 December 2019

Funded under:

H2020-EU.1.2.1.

  • Overall budget:

    € 3 216 250

  • EU contribution

    € 3 216 250

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain