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3-O-sulfated heparan sulfate translocation in altered membrane biology: A newstrategy for early population screening and halting Alzheimer’s neurodegeneration

3-O-sulfated heparan sulfate translocation in altered membrane biology: A newstrategy for early population screening and halting Alzheimer’s neurodegeneration

Objective

ArrestAD proposes a novel and visionary thinking resulting from the demonstration of the central role of a particular heparan sulfate species at the intracellular level in neurons and in circulating cells in the molecular pathology of Alzheimer’s disease (AD). AD is a societal challenge for which there is neither prevention nor possible cure. Research in the field has long been refining classic concepts based on the aggregation of Aβ and tau through initial seeding and then spreading. Our vision is different and based on the demonstration that tau abnormal phosphorylation and aggregation is triggered by the interaction of tau with heparan sulfates internalized in neurons and circulating cells only in AD [UPEC R.1; P.1,2]. Based in this new concept, ArrestAD will establish links between AD genetics, disease hallmarks, and altered traffic and intracellular accumulation of heparan sulfates to generate new knowledge underpinning the development of new strategies for detection and treatment of AD. This will open to radically new technologies addressing two major objectives: 1) proving that specific and early diagnosis of AD is possible in circulating cells, and 2) demonstrating that a new class of drug candidates are able to preventing and/or arresting AD-neurodegeneration. To reach these objectives, ArrestAD brings together internationally recognized experts in AD clinics and diagnosis, in heparan sulfate biology, transcriptomics, interactomics, carbohydrate chemistry, enzymology, cell biology, animal experimentation with AD models, and a SME specialized in the development of diagnosis kits using circulating cells. The high-risk character of this joint science and technology research is offset by the multidisciplinary nature of the Consortium and the high socio-economic gain resulting from success. Based in this technology, we will build a diverse portfolio of future projects that will result in a long-term benefit for citizens, economy and society.
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Coordinator

UNIVERSITE PARIS XII VAL DE MARNE

Address

Avenue Du General De Gaulle 61
94010 Creteil

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 891 181,25

Participants (7)

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THE UNIVERSITY OF LIVERPOOL

United Kingdom

EU Contribution

€ 579 250

FUNDACION DE INVESTIGACION DEL CANCER DE LA UNIVERSIDAD DE SALAMANCA

Spain

EU Contribution

€ 452 375

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

EU Contribution

€ 400 625

INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK

Poland

EU Contribution

€ 518 125

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

France

EU Contribution

€ 383 540

UNIVERSITAT AUTONOMA DE BARCELONA

Spain

EU Contribution

€ 394 875

SCREENCELL

France

EU Contribution

€ 371 125

Project information

Grant agreement ID: 737390

Status

Ongoing project

  • Start date

    1 January 2017

  • End date

    31 December 2020

Funded under:

H2020-EU.1.2.1.

  • Overall budget:

    € 3 991 096,25

  • EU contribution

    € 3 991 096,25

Coordinated by:

UNIVERSITE PARIS XII VAL DE MARNE

France