Objetivo Clonally transmissible cancers are somatic cell lineages that are transmitted between individuals via the transfer of living cancer cells. There are only three known types of naturally occurring clonally transmissible cancers, one of which is a leukemia-like cancer found in marine bivalves, called hemic neoplasia (HN).HN in cockles Cerastoderma edule offers an unique opportunity, over the other naturally occurring transmissible cancers, for the discovery of the genetic drivers of cancer transmissibility because: (1) cockle HN has a polyphyletic origin, which allows the identification of recurrently mutated genes among different unrelated cockle HN lineages; (2) HN provides a reliable in vitro and in vivo model that could be used for driver gene discovery and validation by means of genetic engineering methods; (3) cockle HN represents a nearly endless source of biological resources for study and experimentation on the origins and development of natural clonally transmissible cancers, due to the ubiquity of cockles throughout the Western Atlantic coast of Europe and the high prevalence of HN (>20%).Using HN in cockles as a model for clonally transmissible cancers, this project intends to identify the genomic alterations and mutational processes that drive transmissible cancers to depart from their hosts and evolve as parasitic clonal lineages in the marine environment, for illuminating universal processes that make a cancer contagious, and to identify new/unexpected biological insights into the general mechanisms of cancer metastasis.We will first characterize the clonal structure of cockle transmissible cancers by phylogenetic approaches. Then, we will use NGS analysis to catalogue the somatic alterations that characterize different HN clonal lineages, figure out the mutational processes that operate in marine transmissible cancers, and identify the putative cancer genes that drive cancer transmissibility, which will be finally validated by genome editing approach Ámbito científico natural sciencesbiological sciencesbiological morphologycomparative morphologymedical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesgeneticsmutationmedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsgenomes Palabras clave cancer genomics next-generation sequencing Programa(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Tema(s) ERC-2016-STG - ERC Starting Grant Convocatoria de propuestas ERC-2016-STG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-STG - Starting Grant Institución de acogida UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Aportación neta de la UEn € 989 463,80 Dirección COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N 15782 Santiago De Compostela España Ver en el mapa Región Noroeste Galicia A Coruña Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 989 463,80 Beneficiarios (2) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo UNIVERSIDAD DE SANTIAGO DE COMPOSTELA España Aportación neta de la UEn € 989 463,80 Dirección COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N 15782 Santiago De Compostela Ver en el mapa Región Noroeste Galicia A Coruña Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 989 463,80 UNIVERSIDAD DE VIGO España Aportación neta de la UEn € 503 036,20 Dirección LG CAMPUS LAGOAS MARCOSENDE 36310 Vigo Pontevedra Ver en el mapa Región Noroeste Galicia Pontevedra Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 503 036,20
