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High-valent protein-coordinated catalytic metal sites: Geometric and Electronic ARchitecture

High-valent protein-coordinated catalytic metal sites: Geometric and Electronic ARchitecture

Objective

It is estimated that almost half of all enzymes utilize metal cofactors for their function, for example the respiratory complexes and the oxygen-evolving photosystem II, the most fundamental requirements for aerobic life as we know it. If we could mimic nature’s use of metals for harvesting sunlight, energy conversion and chemical synthesis it would eliminate the need for fossil fuels and greatly increase the possibilities of chemical industry while reducing the environmental impact. Achieving this type of chemistry is an outstanding testament to evolution and understanding it is a glaring challenge to mankind.

These types of reactions are based on very challenging redox chemistry (involving one or several electrons). The key catalytic species are generally high-valent metal clusters with a varying ligand environment, provided by the protein and other bound molecules, that directly controls the reactivity of the inorganic core. To be able to understand and mimic this chemistry it is of central importance to know the geometric and electronic structures of the metal core as well as the entire ligand environment for these usually short-lived and very reactive intermediates. It has, for a number of reasons, proven extremely challenging to obtain these for protein-coordinated catalysts.

The central goal of this project is to determine true and accurate geometric and electronic structures of high-valent di-nuclear Fe/Fe and Mn/Fe metal sites coordinated in protein matrices known to direct these for varied and important chemistry. By combining new X-ray diffraction based techniques with advanced spectroscopy we aim to define how the protein controls the entatic state as well as reactivity and mechanism for some of the most potent catalysts in nature. The results will serve as a basis for design of oxygen-activating catalysts with novel properties.
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Host institution

STOCKHOLMS UNIVERSITET

Address

Universitetsvagen 10
10691 Stockholm

Sweden

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 968 375

Beneficiaries (1)

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STOCKHOLMS UNIVERSITET

Sweden

EU Contribution

€ 1 968 375

Project information

Grant agreement ID: 724394

Status

Ongoing project

  • Start date

    1 June 2017

  • End date

    31 May 2022

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 968 375

  • EU contribution

    € 1 968 375

Hosted by:

STOCKHOLMS UNIVERSITET

Sweden