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Preclinical validation of a novel immunogenic composition to stimulate innate immunity

Objective

Immunotherapy is a promising approach to treat cancer and infectious diseases, but innovative approaches are required.
The cGAS-cGAMP-STING pathway can induce a potent immune response against viruses. It is also implicated in antitumoral immune responses that are effective. We have recently discovered that the small second messenger cGAMP can be packaged by viruses to stimulate immunity in target cells. We have developed methods to produce non-infectious virus-like particles containing cGAMP (cGAMP-VLPs) that strongly stimulate this innovative immune pathway. We will test the idea that cGAMP-VLPs are potent activators of anti-tumoral and anti-viral immunity. To reach this proof-of-concept, we propose pre-clinical development plan in translational mouse models.

Field of science

  • /natural sciences/biological sciences/microbiology/virology
  • /medical and health sciences/health sciences/infectious disease

Call for proposal

ERC-2016-PoC
See other projects for this call

Funding Scheme

ERC-POC - Proof of Concept Grant

Host institution

INSTITUT CURIE
Address
Rue D'ulm 26
75231 Paris
France
Activity type
Research Organisations
EU contribution
€ 150 000

Beneficiaries (1)

INSTITUT CURIE
France
EU contribution
€ 150 000
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations