Preclinical validation of a novel immunogenic composition to stimulate innate immunity

Projektinformationen

STIMUNITY

ID Finanzhilfevereinbarung: 727408

DOI 10.3030/727408

Abgeschlossenes Projekt

EK-Unterschriftsdatum 24 Januar 2017

Startdatum 1 Februar 2017

Enddatum 31 Juli 2018

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 150 000,00

EU-Beitrag € 150 000,00

Koordiniert durch

INSTITUT CURIE
France

Ziel

Immunotherapy is a promising approach to treat cancer and infectious diseases, but innovative approaches are required.
The cGAS-cGAMP-STING pathway can induce a potent immune response against viruses. It is also implicated in antitumoral immune responses that are effective. We have recently discovered that the small second messenger cGAMP can be packaged by viruses to stimulate immunity in target cells. We have developed methods to produce non-infectious virus-like particles containing cGAMP (cGAMP-VLPs) that strongly stimulate this innovative immune pathway. We will test the idea that cGAMP-VLPs are potent activators of anti-tumoral and anti-viral immunity. To reach this proof-of-concept, we
propose pre-clinical development plan in translational mouse models.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › health sciences › infectious diseases
• medical and health sciences › clinical medicine › oncology
• medical and health sciences › basic medicine › immunology › immunotherapy

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-PoC-2016 - ERC-Proof of Concept-2016

Aufforderung zur Vorschlagseinreichung

ERC-2016-PoC

Finanzierungsplan

ERC-POC - Proof of Concept Grant

Gastgebende Einrichtung

INSTITUT CURIE

• Netto-EU-Beitrag: € 150 000,00
• Adresse: RUE D ULM 26 ; 75231 Paris ; Frankreich
• Region: Ile-de-France › Ile-de-France › Paris
• Aktivitätstyp: Research Organisations
• Gesamtkosten: € 150 000,00

Begünstigte (1)

INSTITUT CURIE

Frankreich

• Netto-EU-Beitrag: € 150 000,00
• Adresse: RUE D ULM 26 ; 75231 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Aktivitätstyp: Research Organisations
• Gesamtkosten: € 150 000,00