Objetivo Heart failure affects more than 14 million people in Europe, and is projected to affect about 30 million people by 2020. While the effects of Cardiac Resynchronization Therapy on the wider heart failure population are impressive, benefits at the individual level vary considerably. Depending on the definition, the responder rate CRT is positive in 50-70% of patients, leaving 30-50% without any significant effect. This project will finalise the development of a pacemaker cardiac lead that is 5 times smaller diameter than the state-of-the-art, and start the commercialisation of the product. The project will directly improve the efficiency of Cardiac Resynchronization Therapy (CRT) by reducing the time required for the implantation procedure by 25%, and decrease the yearly healthcare costs by 82 M€/year in Europe. In addition, the project will help European companies to compete in the pacemaker market currently dominated by US companies.Axone IS4 lead combines the advantages of a single lead, which is easy to place in any coronary vein, with the capability to stimulate the left ventricle at 2 widely spaced sites for a more global resynchronization – this has previously required 2 leads to be placed in the heart.The objective of the AXONE project is to:• Finalize product industrialization• Confirm chronic pre-clinical performance with large scale studies • Perform an acute clinical study and a chronic clinical validation • Manufacture clinical and commercial products• Build the marketing plan and prepare the product launch• File CE marking of the class III medical device system• Launch the commercialization of AXONE system and start selling the system in EuropeThis novel approach of multi-site pacing has the potential to become the next CRT therapy device generation, initiated in Europe. This project will give an opportunity to generates 90 M€ direct revenues sales in 2026. Ámbito científico medical and health sciencesclinical medicinecardiology Programa(s) H2020-EC - Horizon 2020 Framework Programme Main Programme H2020-EU.3. - PRIORITY 'Societal challenges H2020-EU.2. - PRIORITY 'Industrial leadership' Tema(s) FTIPilot-01-2016 - Fast Track to Innovation Pilot Convocatoria de propuestas H2020-FTIPilot-2016 Consulte otros proyectos de esta convocatoria Convocatoria de subcontratación H2020-FTIPilot-2016-1 Régimen de financiación IA - Innovation action Coordinador SORIN CRM SAS Aportación neta de la UEn € 1 373 312,50 Dirección AVENUE REAUMUR 4 92140 Clamart Francia Ver en el mapa Región Ile-de-France Ile-de-France Hauts-de-Seine Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 1 961 875,00 Participantes (3) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo HERAEUS DEUTSCHLAND GMBH & CO KG Alemania Aportación neta de la UEn € 537 687,50 Dirección HERAEUSSTRASSE 12-14 63450 Hanau Ver en el mapa Región Hessen Darmstadt Main-Kinzig-Kreis Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Enlaces Contactar con la organización Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 768 125,00 UNIVERSITEIT MAASTRICHT Países Bajos Aportación neta de la UEn € 358 125,00 Dirección MINDERBROEDERSBERG 4 6200 MD Maastricht Ver en el mapa Región Zuid-Nederland Limburg (NL) Zuid-Limburg Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 358 125,00 CENTRE HOSPITALIER ROUEN Francia Aportación neta de la UEn € 425 062,50 Dirección RUE DE GERMONT 1 76038 ROUEN CEDEX Ver en el mapa Región Normandie Haute-Normandie Seine-Maritime Tipo de actividad Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Enlaces Contactar con la organización Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 425 062,50