Objective This project is aimed at accelerating the synthesis of important organic molecules through key enabling technologies towards automatized catalysis and single-carbon insertion reactions. Transferring the simplest carbon units to organic molecules has the potential to change the way we approach synthesis planning through new asymmetric skeletal homologations and rearrangements of simple raw materials, for which only long workarounds exist now. These methods can reduce to half the manipulations required to access relevant medicines, organocatalysts, ligands, bio-molecular tools and photovoltaic devices. They target unreactive functions to introduce fundamental one-carbon units (CO or C) that are present in virtually any organic compound. New powerful reagents that resemble these basic single-carbon units in excited electronic configurations are to be developed for this purpose. The new catalytic methods needed are based on the solid grounds of carbene-transfer reactions and the recent advances of my group in the development of new homogeneous catalysts. Moreover, a new catalyst platform will be developed to complement our existing portfolio for success in the challenging processes targeted in this proposal. We aim to pioneer a fully automatized workflow for research in catalysis that devoid the synthesis of organic ligands replacing them by combinatorial assemblies built in situ from un-structured simple molecules. The new reactions arising from these new catalysts and reagents will expedite the valorization of raw materials (such as carbonyls, olefins and hydrocarbons) into important chiral molecules in a single transformation. This bold aim is a priority of the European Commission for the coming years as it will save time, protect the environment and reduce cost at once. Thus, these innovative technologies have the potential of transforming the research workflow in homogeneous catalysis and the logics of retrosynthesis of organic molecules at a fundamental level. Fields of science natural scienceschemical sciencesorganic chemistryhydrocarbonsnatural scienceschemical sciencescatalysis Keywords Synthetic chemistry Carbene-transfer catalysis asymmetric catalysis C-H functionalization Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-2016-STG - ERC Starting Grant Call for proposal ERC-2016-STG See other projects for this call Funding Scheme ERC-STG - Starting Grant Host institution UNIVERSITAT DE VALENCIA Net EU contribution € 45 461,69 Address AVENIDA BLASCO IBANEZ 13 46010 Valencia Spain See on map Region Este Comunitat Valenciana Valencia/València Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 45 461,69 Beneficiaries (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITAT DE VALENCIA Spain Net EU contribution € 45 461,69 Address AVENIDA BLASCO IBANEZ 13 46010 Valencia See on map Region Este Comunitat Valenciana Valencia/València Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 45 461,69 STOCKHOLMS UNIVERSITET Participation ended Sweden Net EU contribution € 1 441 783,31 Address UNIVERSITETSVAGEN 10 10691 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 441 783,31