Periodic Reporting for period 3 - MITOSENSING (Decoding mitochondrial nutrient-sensing programs in POMC neurons as key determinants of metabolic health)
Reporting period: 2020-04-01 to 2021-09-30
Nutrient-sensing by hypothalamic neurons is a crucial process to monitor the metabolic status of the organism and to coordinate adaptive responses to maintain energy homeostasis. Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus are prototypical cellular sensors and key regulators of appetite, energy expenditure and metabolism. The hypothesis of MITOSENSING is that alterations in specific mitochondrial nutrient-sensing programs in POMC neurons cause energy balance defects that underlie the development of obesity and associated metabolic disorders such as type-2 diabetes (T2D).
The objectives are: 1) to identify transcriptionally-modulated mitochondrial nutrient-sensing programs in POMC neurons; 2) to investigate whether disruption of specific nutrient-sensing programs in POMC neurons cause metabolic disorders; 3) to investigate whether the development of lifestyle-associated metabolic disorders are caused by defective mitochondrial nutrient-sensing programs in POMC neurons.