Objectif An ageing population as well as chronic and infectious diseases, pandemic threats and antimicrobial resistance are currently on the rise. As a consequence, increasing attention is paid to the development of novel drugs, treatments and personal care products. In this context, blue biotechnology offers an opportunity to explore the potential of the marine microbial world to produce biological active metabolites, which may support health and wellbeing. The general goal of this proposal is the extraction and identification of biologically active substances in one of the largest reservoirs of organic material on Earth: the recalcitrant marine dissolved organic matter (RDOM) pool. This pool is an unexplored potential source of bioactive substances. For this purpose, the RDOM will be extracted from (1) one of the oldest water masses of the global ocean located at intermediate depths of the North Pacific and (2) the reworked DOM of marine sediments porewater in the North Sea. A comparative screen will be performed with the more recent surface oceanic water of the North Pacific. The antioxidant, immunostimulant and antitumoral potential of these DOM samples will be explored to evaluate possible cosmetical and pharmaceutical suitability. The DOM molecular diversity and features identified by mass spectrometry and nuclear magnetic resonance will be correlated with the different modes of bioactivity. This proposal will enable Dr. Catalá to broaden her expertise on molecular characterization of the DOM pool, to learn new methodologies of bioactive substances identification as well as to meet future challenges on marine natural product research, endorsed by the H2020 Societal Challenges of 'Health, Demographic Change and Wellbeing' and 'Marine Research and the Bioeconomy'. This combination of expertise is unique, and thus will be a milestone in Dr. Catalá career towards an independent scientist of high international visibility. Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural sciencesearth and related environmental sciencesoceanographynatural scienceschemical sciencesanalytical chemistrymass spectrometrynatural sciencesbiological sciencesmicrobiologynatural sciencesearth and related environmental sciencesgeochemistrybiogeochemistry Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2016 - Individual Fellowships Appel à propositions H2020-MSCA-IF-2016 Voir d’autres projets de cet appel Régime de financement MSCA-IF-EF-ST - Standard EF Coordinateur CARL VON OSSIETZKY UNIVERSITAET OLDENBURG Contribution nette de l'UE € 159 460,80 Adresse AMMERLAENDER HEERSTRASSE 114-118 26129 Oldenburg Allemagne Voir sur la carte Région Niedersachsen Weser-Ems Oldenburg (Oldenburg), Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 159 460,80