Understanding the physical biology of adult blood stem cells

Projektinformationen

PHYSBIOHSC

ID Finanzhilfevereinbarung: 715371

DOI 10.3030/715371

Abgeschlossenes Projekt

EK-Unterschriftsdatum 9 März 2017

Startdatum 1 Mai 2017

Enddatum 31 Oktober 2022

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 1 500 000,00

EU-Beitrag € 1 500 000,00

Koordiniert durch

UNIVERSITY OF YORK
United Kingdom

Ziel

The discovery of functional heterogeneity in normal and malignant stem cells has shifted our understanding of how single cells are subverted to drive cancer. To design therapies for diseases of stem cell origin and to better provide cell populations for clinical applications, it is critical to understand this diversity at the single cell level. This proposal focuses on understanding the complex biology of normal and malignant stem cells and the impact of individual mutations on clonal evolution by studying the physical and quantitative aspects of single blood stem cells.

This proposal aims to study single blood stem cell biomechanics and clonal evolution by leveraging new inter-disciplinary technologies and approaches and applying them to functionally defined mouse and human blood stem cell populations. It will combine in vitro and in vivo biological assays with mathematical modelling and microfluidic technology in an iterative manner across both human and mouse stem cell populations.

Wissenschaftliches Gebiet

• medical and health sciences › medical biotechnology › cells technologies › stem cells
• natural sciences › biological sciences › genetics › mutation
• medical and health sciences › clinical medicine › oncology
• natural sciences › biological sciences › biophysics
• natural sciences › mathematics › applied mathematics › mathematical model

Schlüsselbegriffe

• physical biology
• microfluidic devices
• mathematical models
• quantitative biology
• cell fate choice

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-2016-STG - ERC Starting Grant

Aufforderung zur Vorschlagseinreichung

ERC-2016-STG

Finanzierungsplan

ERC-STG - Starting Grant

Gastgebende Einrichtung

UNIVERSITY OF YORK

• Netto-EU-Beitrag: € 1 046 670,00
• Adresse: HESLINGTON ; YO10 5DD York North Yorkshire ; Vereinigtes Königreich
• Region: Yorkshire and the Humber › North Yorkshire › York
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 1 046 670,00

Begünstigte (2)

UNIVERSITY OF YORK

Vereinigtes Königreich

• Netto-EU-Beitrag: € 1 046 670,00
• Adresse: HESLINGTON ; YO10 5DD York North Yorkshire
• Region: Yorkshire and the Humber › North Yorkshire › York
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 1 046 670,00

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Beteiligung beendet

Vereinigtes Königreich

• Netto-EU-Beitrag: € 453 330,00
• Adresse: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge
• Region: East of England › East Anglia › Cambridgeshire CC
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 453 330,00