Obiettivo Despite having long been overlooked, paternal effects (influence of fathers on offspring traits via mechanisms other than the transmission of alleles) are now recognized as affecting a broad range of phenotypic traits in the next generation. There is, for example, increasing evidence for transgenerational effects of paternal stress levels with consequences on offspring health. In most cases, the proximate mechanism mediating these paternal effects on offspring remains unknown. Recent studies show that these transgenerational effects might be mediated, at least in part, by telomere attrition. Telomeres are regions of non-coding DNA at the end of eukaryotic chromosomes. Telomeres shorten at each cell division or when cells are exposed to oxidative stress, resulting in telomere shortening with aging. A permanent arrest in the cell cycle occurs when telomeres are shortened to a critical length, thereby increasing risk factors in a large number of diseases. Consequently, telomere length predicts remaining lifespan, with individuals with the shortest telomeres displaying the poorest survival prospects.Telomeres are very sensitive to damage induced by oxidative stress and paternal exposure to stressors may thus affect telomere length in sperm before fertilization as well as inherited by the offspring, with consequences for aging and disease susceptibility. In this project, I propose to test this hypothesis by examining the three following aims using a captive population of zebra finches (Taeniopygia guttata):• Measure the effect of stress exposure on sperm telomere length through an experimental manipulation of stress levels at the time of sperm production.• Determine links between paternal sperm telomere length and offspring telomere length at birth using artificial insemination experiments.• Elucidate the effects of sperm telomere length on offspring development and disease susceptibility. Campo scientifico medical and health sciencesclinical medicinegynaecologyreproductive medicinemedical and health sciencesclinical medicineobstetricsmedical and health sciencesbasic medicinephysiologymedical and health sciencesclinical medicineembryologynatural sciencesbiological sciencesgeneticsgenomeseukaryotic genomes Parole chiave Sperm telomere stress paternal effect immunity oxidative stress Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2016 - Individual Fellowships Invito a presentare proposte H2020-MSCA-IF-2016 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinatore THE UNIVERSITY OF EXETER Contribution nette de l'UE € 195 454,80 Indirizzo THE QUEEN'S DRIVE NORTHCOTE HOUSE EX4 4QJ Exeter Regno Unito Mostra sulla mappa Regione South West (England) Devon Devon CC Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 195 454,80
