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RAtionalising Membrane Protein crystallisation

RAtionalising Membrane Protein crystallisation

Objective

Membrane proteins form more than 85% of drug targets, but just 600 unique membrane protein crystal structures have been determined. A better understanding of how to crystallize membrane proteins reliably is therefore urgently required. The Innovative Training Network “RAtionalising Membrane Protein crystallisation” – RAMP will bring together cutting-edge physical chemistry methods for crystallisation condition control and phase diagram exploration, and the development of new lipids and screens in conjunction with industry with the most challenging biological problems. The network includes expert academic and industrial research groups in crystallisation theory, methods development, membrane protein crystallography, drug development and novel structural techniques like time-resolved and neutron crystallography. We will develop new, rational methods for crystallising membrane proteins, focusing particularly on transporters that are also interesting drug targets. The new robust crystallisation methods will also allow us to use emerging European research infrastructures like XFEL or ESS to gain insight into membrane protein function because the techniques will provide the necessary precise control of crystal size.
A structured training programme organized by academia and industry together will equip the early stage researchers with the skills needed for a successful research career in the field of structural biology. Frequent secondments, research visits and meetings between early-career scientists ensure an efficient exchange of ideas and practical experiences between different groups leading to better integration of European research and innovations in structural biology. Supervision and mentoring by several senior scientists will give the researchers a strong scientific education and make them highly competitive in the work place of tomorrow. The work programme here will improve European competitiveness and advance graduate training.
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Coordinator

UNIVERSITE GRENOBLE ALPES

Address

621, Avenue Centrale
38401 Saint Martin D'Heres

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 525 751,20

Participants (8)

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UNIVERSITY OF LEEDS

United Kingdom

EU Contribution

€ 546 575,76

EUROPEAN SPALLATION SOURCE ERIC

Sweden

EU Contribution

€ 263 659,32

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 580 163,76

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

Ireland

EU Contribution

€ 265 674,60

UNIVERSITAET HAMBURG

Germany

EU Contribution

€ 249 216,48

NATIONAL UNIVERSITY OF IRELAND MAYNOOTH

Ireland

EU Contribution

€ 265 674,60

UNIVERSITY OF SURREY

United Kingdom

EU Contribution

€ 273 287,88

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 273 287,88

Project information

Grant agreement ID: 722687

Status

Ongoing project

  • Start date

    1 March 2017

  • End date

    28 February 2021

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 243 291,48

  • EU contribution

    € 3 243 291,48

Coordinated by:

UNIVERSITE GRENOBLE ALPES

France