Obiettivo Cell-to-cell communication is fundamental to multicellular organisms. The exchange of information and resources between cells and tissues enables co-ordination of responses to environmental and developmental signals. In plants, the cytoplasm of adjacent cells is connected by plasma membrane-line pores called plasmodesmata (PD) that cross the cell wall, generating cytoplasmic continuity between cells and tissues. This interconnected cytoplasm is termed the symplast and is unique to plants. In plants, growing evidence suggests that innate immune responses rely on regulation of symplastic connectivity. My group previously discovered that regulation of PD (whether they are open or closed) is critical for immune responses. Further, we have shown that pathogens suppress host regulation of PD in an effort to maintain symplastic continuity between cells. We don’t know why the host regulates the symplast during defence: while data suggests that different defence responses might differently exploit the symplast, we don’t understand how the symplast defines the success of a response. Similarly, we don’t know how a pathogen benefits from maintaining connectivity with surrounding host cells – is this to allow the movement of molecules to suppress defence, or is it to optimise access to host resources? This programme will investigate the question of how the symplast contributes to defence and infection strategies. We aim to understand how these strategies play out in an infection context. We will use experimental and computational approaches to generate models that allow us to predict the outcome of infection upon the basis of symplastic processes and PD regulation. Ultimately, this will create a framework for novel strategies to enhance pathogen resistance. Campo scientifico medical and health sciencesbasic medicineimmunology Parole chiave innate immunity cell-to-cell communication plasmodesmata symplast MAMP-triggered immunity Programma(i) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Argomento(i) ERC-2016-COG - ERC Consolidator Grant Invito a presentare proposte ERC-2016-COG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-COG - Consolidator Grant Istituzione ospitante JOHN INNES CENTRE Contribution nette de l'UE € 2 162 500,00 Indirizzo NORWICH RESEARCH PARK COLNEY NR4 7UH Norwich Regno Unito Mostra sulla mappa Regione East of England East Anglia Breckland and South Norfolk Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 2 162 500,00 Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto JOHN INNES CENTRE Regno Unito Contribution nette de l'UE € 2 162 500,00 Indirizzo NORWICH RESEARCH PARK COLNEY NR4 7UH Norwich Mostra sulla mappa Regione East of England East Anglia Breckland and South Norfolk Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 2 162 500,00