Objetivo The microbial community in the human intestine is crucial to the health and nutrition of the host. Loss of the fragile balance within this complex ecosystem is involved in numerous pathologies, including inflammatory bowel disease (IBD). The incidence of IBD is increasing and affects individuals in challenging years of their lives, with immunosuppressive treatments that are not always effective. IBD results from a combination of genetic predisposition, alteration of the gut microbiota, and environmental influences. Thus, deciphering the host-bacteria crosstalk will improve our understanding of IBD and enable new preventive and therapeutic strategies. Caspase recruitment domain 9 (Card9), one of the IBD susceptibility genes, codes for a protein involved in the response to fungi and bacteria. Sokol and colleagues showed that Card9-/- mice have an increased susceptibility to colitis, due to an altered gut microbiota that is not able to metabolise tryptophan into aryl hydrocarbon receptor (AhR) ligands. In humans, comparable mechanisms seem to be involved, as microbiota of IBD patients exhibit impaired production of AhR ligands, which mirrors the Card9-/- genotype.We aim to decipher the mechanisms involved in the modulation of the microbiota and its metabolic activity by Card9. For this purpose, we will take advantage of a strong collaborative environment and cutting-edge techniques, including gnotobiotic animals, cre-lox technology, transcriptomics, metabolomics and systems biology. Specifically, we plan to identify (i) new pathways and cell types involved in the modulation of the microbiota and its metabolic activity, and (ii) microorganisms and metabolites activating AhR receptors in the gut. This highly innovative and integrative project will allow me to expand my conceptual and technical knowledge of the gut-microbiota interface, acquire new key skills and strengthen my scientific network. Ámbito científico medical and health sciencesclinical medicinegastroenterologyinflammatory bowel diseasenatural scienceschemical sciencesorganic chemistryhydrocarbonsnatural sciencesbiological sciencesmicrobiologymycologymedical and health scienceshealth sciencesnutritionmedical and health sciencesbasic medicinepathology Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2016 - Individual Fellowships Convocatoria de propuestas H2020-MSCA-IF-2016 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-EF-ST - Standard EF Coordinador INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Aportación neta de la UEn € 185 076,00 Dirección 147 RUE DE L'UNIVERSITE 75007 Paris Francia Ver en el mapa Región Ile-de-France Ile-de-France Paris Tipo de actividad Research Organisations Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 185 076,00