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Remote Assessment of Disease and Relapse in Central Nervous System Disorders

Objective

Background: Long term conditions require monitoring of patients, traditionally conducted in the clinic, to monitor treatment effects, adverse events and disease course. This can be inefficient and cumbersome – clinic visits may be too infrequent to identify individuals at risk of significant changes in disease state (e.g. relapse) and place unnecessary burden on patients and providers.

Smartphone and wearable technologies have led to an exponential growth in the amount of information which can be collected on patients unobtrusively and at low cost. Sensors collect data passively, and active monitoring, using experience sampling, provides information on multiple parameters. Such technologies could monitor long term outcomes of patients, at scale, and provide fine-grained information on outcomes, available in real time and at low-cost, enabling services to offer more responsive and efficient care.

Whilst there is growing interest in the application of RMT in health, the field is in its infancy. The private-public partnership fostered by IMI2 is an ideal way to overcome the inherent challenges of this field.

Our ultimate goal is to improve patient outcomes through remote assessment. To achieve this we will create a pipeline for developing, testing and implementing RMT in depression, multiple sclerosis and epilepsy. The pipeline will include a data management and modelling infrastructure applicable to other disorders and with the flexibility of design to be future-proofed against further technological innovation. We will provide data on implementation barriers and facilitators gleaned from patients, clinicians, regulator and payers which will optimise the pathways for regulatory approval and uptake.

Program of Work: In order to test the feasibility and predictive power of RMT four main components are required: (1) Excellent project oversight, management, and a dissemination and exploitation strategy;

Coordinator

KING'S COLLEGE LONDON
Net EU contribution
€ 4 078 266,75
Address
Strand
WC2R 2LS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 142 827,00

Participants (27)

PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI
Italy
Net EU contribution
€ 180 000,31
Address
Via Pilastroni 4
25125 Brescia
Activity type
Research Organisations
Non-EU contribution
€ 0,00
STICHTING LYGATURE
Netherlands
Net EU contribution
€ 975 961,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Jaarbeursplein 6
3521 AL Utrecht
Activity type
Other
Non-EU contribution
€ 1,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

THE HYVE BV
Netherlands
Net EU contribution
€ 370 000,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Arthur Van Schendelstraat 650
3511 MJ Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
Net EU contribution
€ 552 980,19
Address
Via Olgettina 58
20132 Milano
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 200 000,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

OSPEDALE SAN RAFFAELE SRL
Italy
Net EU contribution
€ 0,00
Address
Via Olgettina 60
20132 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
Net EU contribution
€ 427 235,00
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 125 000,00
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
Net EU contribution
€ 625 000,00
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
East Midlands (England) Derbyshire and Nottinghamshire Nottingham
CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.
Spain
Net EU contribution
€ 550 606,25
Address
Calle Monforte De Lemos 5
28029 Madrid
Activity type
Research Organisations
Non-EU contribution
€ 150 000,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FUNDACIO PRIVADA PER A LA RECERCA I LA DOCENCIA SANT JOAN DE DEU
Spain
Net EU contribution
€ 124 375,00
Address
Santa Rosa 39-4
08950 Esplugues De Llobregat
Activity type
Research Organisations
Non-EU contribution
€ 0,00
SOFTWARE AG
Germany
Net EU contribution
€ 0,00
Address
Uhlandstrasse 12
64297 Darmstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 903 750,00
Region
Darmstadt Darmstadt, Kreisfreie Stadt
 
REGION HOVEDSTADEN
Denmark
Net EU contribution
€ 405 000,00
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 125 000,00
STICHTING VUMC
Netherlands
Net EU contribution
€ 488 000,00
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations
Non-EU contribution
€ 90 000,00
UNIVERSITAETSKLINIKUM FREIBURG
Germany
Net EU contribution
€ 825 000,00
Address
Hugstetter Strasse 49
79106 Freiburg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
STICHTING IMEC NEDERLAND
Netherlands
Net EU contribution
€ 111 000,00
Address
High Tech Campus 31
5656 AE Eindhoven
Activity type
Research Organisations
Non-EU contribution
€ 0,00
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Net EU contribution
€ 526 000,00
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 90 000,00
Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
NORTHWESTERN UNIVERSITY
United States
Net EU contribution
€ 0,00
Address
Clark Street 633
60208 Evanston, Illinois
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 141 275,00
UNIVERSITAT PASSAU

Participation ended

Germany
Net EU contribution
€ 116 352,00
Address
Innstrasse 41
94032 Passau
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA' DEGLI STUDI DI BERGAMO
Italy
Net EU contribution
€ 125 000,00
Address
Via Salvecchio 19
24129 Bergamo
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
Net EU contribution
€ 62 500,00
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INTEL CORPORATION (UK) LIMITED

Participation ended

United Kingdom
Net EU contribution
€ 0,00
Address
Pipers Way
SN3 1RJ Swindon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 227 500,00
Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon
 
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation ended

Germany
Net EU contribution
€ 23 076,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 830,75
JANSSEN PHARMACEUTICA NV
Belgium
Net EU contribution
€ 0,00
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 9 805 927,00
BIOGEN IDEC LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Innovation House 70 Norden Road
SL6 3AY Maidenhead
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 300 000,00
Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Berkshire
H. LUNDBECK AS
Denmark
Net EU contribution
€ 0,00
Address
Ottiliavej 7-9
2500 Valby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 820 000,00
UCB BIOPHARMA
Belgium
Net EU contribution
€ 0,00
Address
Allee De La Recherche 60
1070 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 000 000,00
Region
Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest
MSD CZECH REPUBLIC SRO
Czechia
Net EU contribution
€ 0,00
Address
Svornosti 3321/2
15000 Praha
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 500 000,00
Region
Praha Hlavní město Praha
 
UNIVERSITAET AUGSBURG
Germany
Net EU contribution
€ 433 647,50
Address
Universitaetsstrasse 2
86159 Augsburg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 90 000,00