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PERtussIS COrrelates of Protection Europe - Sofia ref.: 115910

Objective

Pertussis vaccines have been very successful in reducing the global burden of pertussis-related disease. However, in the last decade there has been a rise in pertussis incidence, particularly in vaccinated adolescents and adults in industrialized countries. The increased circulation of B. pertussis (Bp) constitutes a risk for transmission to vulnerable infants and older adults. Additionally, immunity in humans has been shown to wane rapidly after immunization with pertussis vaccines, especially with acellular pertussis (aP) vaccines, suggesting that the improved reactogenicity profile of aP compared to whole cell pertussis vaccines, may be accompanied by differences in duration of immunity. The key objectives of PERISCOPE are to 1. identify biomarkers of protection against Bp colonization and disease; 2. foster scientific innovation and rebuild the ecosystem and technical infrastructure needed in Europe to allow the future evaluation of novel pertussis vaccine candidates and 3. improve understanding of the pathogenesis of Bp infection and its potential impact on the recently observed changes in pertussis epidemiology. To reach these objectives, PERISCOPE brings together a selected group of internationally recognized public and EFPIA partners with strong expertise in clinical trials, immunology, molecular microbiology, human and animal challenge models and bioinformatics. We will initiate a series of (pre)clinical studies and develop harmonized human and animal challenge models, standardized assays and cutting-edge techniques to unravel the innate and adaptive responses to Bp. This will allow us to identify biomarkers of protection and durable immunity. PERISCOPE will thus facilitate the accelerated development and registration of novel pertussis vaccines and/or guide optimal use of vaccination strategies. The introduction of improved pertussis vaccines will help to reduce the global burden of pertussis.

Field of science

  • /medical and health sciences/basic medicine/immunology
  • /natural sciences/biological sciences/microbiology
  • /medical and health sciences/health sciences/epidemiology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

H2020-JTI-IMI2-2015-03-two-stage
See other projects for this call

Funding Scheme

IMI2-RIA - Research and Innovation action

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 701 114,62

Participants (23)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 1 779 999
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Department of Health
United Kingdom
EU contribution
€ 564 110
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
INSTITUT PASTEUR DE LILLE FONDATION
France
EU contribution
€ 799 998
Address
Rue Du Professeur Calmette 1
59019 Lille
Activity type
Research Organisations
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
EU contribution
€ 650 000
Address
College Green
2 Dublin
Activity type
Higher or Secondary Education Establishments
TURUN YLIOPISTO
Finland
EU contribution
€ 1 475 000
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 1 500 243
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Participation ended

United Kingdom
EU contribution
€ 84 380,69
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 2 021 832
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
MIKROBIOLOGICKY USTAV AV CR V.V.I
Czechia
EU contribution
€ 300 000
Address
Videnska 1083
142 00 Praha 4
Activity type
Research Organisations
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 0
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF BATH
United Kingdom
EU contribution
€ 399 455
Address
Claverton Down
BA2 7AY Bath
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 1 492 500
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE SALAMANCA
Spain
EU contribution
€ 547 500
Address
Calle Patio De Escuelas 1
37008 Salamanca
Activity type
Higher or Secondary Education Establishments
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 299 995
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
EU contribution
€ 0
Address
Rue Du Bugnon 21
1011 Lausanne
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 2 561 944
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
Q-BIOLOGICALS NV
Belgium
EU contribution
€ 175 097
Address
Technologiepark 4
9052 Gent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNITED KINGDOM RESEARCH AND INNOVATION

Participation ended

United Kingdom
EU contribution
€ 67 125,75
Address
Polaris House North Star Avenue
SN2 1FL Swindon
Activity type
Research Organisations
MEDICAL RESEARCH COUNCIL

Participation ended

United Kingdom
EU contribution
€ 0
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
EU contribution
€ 531 250
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI PASTEUR SA
France
EU contribution
€ 0
Address
Avenue Pont Pasteur, 2
69007 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GLAXOSMITHKLINE BIOLOGICALS SA
Belgium
EU contribution
€ 0
Address
Rue De L Institut 89
1330 Rixensart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 2 048 455,94
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments