CORDIS
EU research results

CORDIS

English EN

Psychiatric Ratings using Intermediate Stratified Markers - Sofia ref.: 115916

Project information

Grant agreement ID: 115916

Status

Closed project

  • Start date

    1 April 2016

  • End date

    30 September 2019

Funded under:

H2020-EU.3.1.7.

  • Overall budget:

    € 16 195 875

  • EU contribution

    € 8 080 000

Coordinated by:

RIJKSUNIVERSITEIT GRONINGEN

Netherlands

Objective

The current nosology of neuropsychiatric disorders allows for a pragmatic approach to treatment choice, regulation and clinical research. However, without a biological rationale for these disorders, drug development has dramatically stagnated in the past decades. In a coordinated effort encompassing academic experts, SMEs, patient and family organizations, regulators, ECNP and EFPIA partners, this project aims to develop a quantitative biological approach to the understanding and classification of neuropsychiatric diseases to accelerate the discovery and development of better treatments for patients. This project will concentrate on Schizophrenia (SZ), Alzheimer’s disease (AD), and Major Depression (MD), as these disorders share part of their symptomatology, in particular social withdrawal and certain cognitive deficits, such as deficits in attention, working memory and sensory processing. By applying innovative technologies (e.g. EEG, cognitive tasks, (f)MRI,
smartphone monitoring, and (epi-)genetics) to deep phenotype a clinical cohort of SZ and AD patients combined with a wider analysis of existing clinical data sets from major European and global disease cohorts that also include MD, we will define a set of quantifiable biological parameters best able to cluster and differentiate SZ, AD, and MD patients that do, or do not, exhibit social withdrawal. First, by mining large European SZ, AD and MD cohort datasets with already available social and cognitive proxy measures, and, second, by obtaining objective measures of social exploration levels (using a novel smartphone application), phenotypic relationships with social and cognitive measures will be further tested. For instance we might predict that socially withdrawn individuals may have lower cognitive functioning and poorer clinical course compared to those who are more socially engaged.

Coordinator

RIJKSUNIVERSITEIT GRONINGEN

Address

Broerstraat 5
9712cp Groningen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 105 481

Participants (22)

P1VITAL LIMITED

United Kingdom

EU Contribution

€ 1 226 586,11

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

EU Contribution

€ 840 250

CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.

Spain

EU Contribution

€ 678 450

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA

Italy

EU Contribution

€ 100 000

STICHTING VUMC

Netherlands

EU Contribution

€ 775 000

BIOTRIAL

France

EU Contribution

€ 350 000

DRUG TARGET ID BV

Netherlands

EU Contribution

€ 200 250

THE UNIVERSITY OF EXETER

United Kingdom

EU Contribution

€ 90 000

SBGNEURO LTD

United Kingdom

EU Contribution

€ 490 500

Concentris Research Management GmbH

Germany

EU Contribution

€ 315 000

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 334 775

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 100 000

STICHTING BURO ECNP

Netherlands

EU Contribution

€ 168 500

EUROPESE FEDERATIE VAN FAMILIEVERENIGINGEN VAN PSYCHIATRISCH ZIEKE PERSONEN IVZW

Belgium

EU Contribution

€ 18 563

BOEHRINGER INGELHEIM INTERNATIONALGMBH

Germany

NOVARTIS PHARMA AG

Switzerland

PFIZER LIMITED

United Kingdom

F. HOFFMANN-LA ROCHE AG

Switzerland

TAKEDA DEVELOPMENT CENTRE EUROPE LTD

United Kingdom

Eli Lilly and Company Limited

United Kingdom

JANSSEN PHARMACEUTICA NV

Belgium

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

EU Contribution

€ 286 644,89

Project information

Grant agreement ID: 115916

Status

Closed project

  • Start date

    1 April 2016

  • End date

    30 September 2019

Funded under:

H2020-EU.3.1.7.

  • Overall budget:

    € 16 195 875

  • EU contribution

    € 8 080 000

Coordinated by:

RIJKSUNIVERSITEIT GRONINGEN

Netherlands

This project is featured in...