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Biomarker Enterprise to Attack DKD - Sofia ref.: 115974

Objective

Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD), and its global incidence and prevalence have reached epidemic dimensions in recent years. Unfortunately, there are no effective means to prevent or cure DKD, the few existing treatments have limited effect and very few alternative therapies have emerged in the past years. Lack of new predictive and prognostic biomarkers for a more accurate patient stratification, limited access to kidney tissue from patients at various stages of DKD as well as novel model systems to better understand the pathogenesis of the disease, are likely reasons for the stagnating development of new treatments.

The BEAt-DKD consortium combines outstanding basic and translational researchers in nephropathy, diabetes, kidney model systems, imaging techniques and systems biology, and includes leaders of diabetes and kidney disease-relevant
IMI1, FP7 and US consortia, like SUMMIT, KIDNEYCONNECT, Syskid, CPROBE and C-Path, in an unprecedented search for new and better biomarkers for DKD, through a better understanding of the disease.

Jointly, the partners have access to vast and very relevant clinical cohorts and trials, state-of-the-art analysis and imaging techniques, novel model systems and the long-standing experience and networks to make this collaboration a success. By involving regulatory agencies throughout the project, BEAt-DKD aims at making the introduction and acceptance of new tools as efficient as possible.

The overall goals of BEAt-DKD are (1) to provide a holistic systems medicine view of the pathogenesis of DKD with the aim to identify targetable mechanisms and pathways underlying initiation and progression of DKD, applying a novel sub-classification of diabetes, and (2) to identify and validate biomarkers of disease progression and treatment responses representing first steps towards precision medicine in the management of DKD.

Coordinator

LUNDS UNIVERSITET
Net EU contribution
€ 2 674 336,55
Address
Paradisgatan 5C
22100 Lund
Sweden

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 1 500 727,00

Participants (37)

HELSINGIN YLIOPISTO
Finland
Net EU contribution
€ 975 000,00
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 22 500,00
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
Net EU contribution
€ 1 942 896,25
Address
Hanzeplein 1
9713 GZ Groningen

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 516 636,25
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Participation ended

United Kingdom
Net EU contribution
€ 5 077,91
Address
Wellington Square University Offices
OX1 2JD Oxford

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ITA-SUOMEN YLIOPISTO
Finland
Net EU contribution
€ 200 000,00
Address
Yliopistonranta 1 E
70211 Kuopio

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY OF DUNDEE
United Kingdom
Net EU contribution
€ 655 000,00
Address
Nethergate
DD1 4HN Dundee

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Region
Eastern Scotland Angus and Dundee City
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE UNIVERSITY OF EXETER
United Kingdom
Net EU contribution
€ 650 655,75
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter

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Region
South West (England) Devon Devon CC
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 172 485,00
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
Net EU contribution
€ 150 000,00
Address
Via Mario Negri 2
20156 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Research Organisations
Non-EU contribution
€ 0,00
TURUN YLIOPISTO
Finland
Net EU contribution
€ 235 313,23
Address
Yliopistonmaki
20014 Turku

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Region
Manner-Suomi Etelä-Suomi Varsinais-Suomi
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA
Finland
Net EU contribution
€ 92 688,03
Address
Kiinamyllynkatu 4-8
20520 Turku

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Region
Manner-Suomi Etelä-Suomi Varsinais-Suomi
Activity type
Research Organisations
Non-EU contribution
€ 48 460,00
UNIVERSITAETSKLINIKUM FREIBURG

Participation ended

Germany
Net EU contribution
€ 44 083,18
Address
Hugstetter Strasse 49
79106 Freiburg

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Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY OF BRISTOL
United Kingdom
Net EU contribution
€ 571 448,86
Address
Beacon House Queens Road
BS8 1QU Bristol

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Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 269 318,00
UNIVERSITY OF LEEDS
United Kingdom
Net EU contribution
€ 434 389,75
Address
Woodhouse Lane
LS2 9JT Leeds

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Region
Yorkshire and the Humber West Yorkshire Leeds
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 100 000,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

THE LEEDS TEACHING HOSPITALS NATIONAL HEALTH SERVICE TRUST
United Kingdom
Net EU contribution
€ 140 717,00
Address
St James's University Hospital, Beckett Street
LS9 7TF Leeds

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Region
Yorkshire and the Humber West Yorkshire Leeds
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITY OF HULL
United Kingdom
Net EU contribution
€ 250 000,00
Address
Cottingham Road
HU6 7RX Hull

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Region
Yorkshire and the Humber East Yorkshire and Northern Lincolnshire Kingston upon Hull, City of
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CHU HOPITAUX DE BORDEAUX
France
Net EU contribution
€ 33 087,08
Address
Rue Dubernat 12
33404 Talence

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Region
Nouvelle-Aquitaine Aquitaine Gironde
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 265 000,00
UNIVERSITATSKLINIKUM ERLANGEN
Germany
Net EU contribution
€ 387 500,00
Address
Maximiliansplatz 2
91054 Erlangen

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Region
Bayern Mittelfranken Erlangen, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
Net EU contribution
€ 930 000,00
Address
Christoph Probst Platz 1
6020 Innsbruck

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Region
Westösterreich Tirol Innsbruck
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 175 000,00
KLINIKUM DER UNIVERSITAET REGENSBURG
Germany
Net EU contribution
€ 360 000,00
Address
Frans Josef Strauss Allee 11
93053 Regensburg

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Region
Bayern Oberpfalz Regensburg, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Net EU contribution
€ 950 000,00
Address
Spitalgasse 23
1090 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 437 750,00
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy
Net EU contribution
€ 568 000,00
Address
Piazza Umberto I 1
70121 Bari

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Region
Sud Puglia Bari
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

APULIABIOTECH SOCIETA CONSORTILE AR L
Italy
Net EU contribution
€ 42 000,00
Address
Via Per Casamassima Km 3
70010 Valenzano

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Sud Puglia Bari
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

AZIENDA OSPEDALIERO UNIVERSITARIA CONSORZIALE POLICLINICO DI BARI
Italy
Net EU contribution
€ 10 000,00
Address
Piazza Giulio Cesare 11
70124 Bari

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Region
Sud Puglia Bari
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
LIPOTYPE
Germany
Net EU contribution
€ 300 000,00
Address
Tatzberg 47
01307 Dresden

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Sachsen Dresden Dresden, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITY OF MICHIGAN THE REGENTS OF THE UNIVERSITY OF MICHIGAN
United States
Net EU contribution
€ 0,00
Address
South Street 3003 1068
46109 1274 Ann Arbor

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 1 607 466,75
SIB SWISS INSTITUTE OF BIOINFORMATICS
Switzerland
Net EU contribution
€ 315 000,00
Address
Rue Michel Servet 1 Cmu
1206 Geneve

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Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Activity type
Research Organisations
Non-EU contribution
€ 12 500,00
JDRF INTERNATIONAL
United States
Net EU contribution
€ 0,00
Address
26 Broadway 14Th Floor
10004 New York

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Activity type
Research Organisations
Non-EU contribution
€ 487 363,00
ABBVIE INC

Participation ended

United States
Net EU contribution
€ 0,00
Address
North Waukegan Road 1
60064 North Chicago Il

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 627 548,14
SANOFI-AVENTIS DEUTSCHLAND GMBH

Participation ended

Germany
Net EU contribution
€ 0,00
Address
Bruningstrasse 50
65929 Frankfurt Am Main

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 2 373 502,00
ASTELLAS PHARMA EUROPE BV
Netherlands
Net EU contribution
€ 0,00
Address
Sylviusweg 84
2333 BE Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 815 000,00
ELI LILLY AND COMPANY LTD
United Kingdom
Net EU contribution
€ 0,00
Address
Lilly House Basingview
RG21 4FA Basingstoke

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Region
South East (England) Hampshire and Isle of Wight North Hampshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 875 000,00
Bayer Pharma AG

Participation ended

Germany
Net EU contribution
€ 0,00
Address
Muellerstrasse 178
13353 Berlin

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Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 992 600,00
NOVO NORDISK A/S
Denmark
Net EU contribution
€ 0,00
Address
Novo Alle 1
2880 Bagsvaerd

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Region
Danmark Hovedstaden Københavns omegn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 250 000,00
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
Net EU contribution
€ 0,00
Address
Binger Strasse
55218 Ingelheim

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 015 000,00
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
Net EU contribution
€ 1 544 467,96
Address
Martinistrasse 52
20251 Hamburg

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 375 000,00
ANTAROS MEDICAL AB
Sweden
Net EU contribution
€ 16 125,00
Address
Bioventure Hub Pepparedsleden 1
431 83 Molndal

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Södra Sverige Västsverige Västra Götalands län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
THE UNIVERSITY OF SHEFFIELD
United Kingdom
Net EU contribution
€ 608 150,45
Address
Firth Court Western Bank
S10 2TN Sheffield

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Region
Yorkshire and the Humber South Yorkshire Sheffield
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 221 861,00
BAYER AKTIENGESELLSCHAFT
Germany
Net EU contribution
€ 0,00
Address
Kaiser-wilhelm-allee 1
51373 Leverkusen

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Region
Nordrhein-Westfalen Köln Leverkusen, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 340 000,00