Objective
Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD), and its global incidence and prevalence have reached epidemic dimensions in recent years. Unfortunately, there are no effective means to prevent or cure DKD, the few existing treatments have limited effect and very few alternative therapies have emerged in the past years. Lack of new predictive and prognostic biomarkers for a more accurate patient stratification, limited access to kidney tissue from patients at various stages of DKD as well as novel model systems to better understand the pathogenesis of the disease, are likely reasons for the stagnating development of new treatments.
The BEAt-DKD consortium combines outstanding basic and translational researchers in nephropathy, diabetes, kidney model systems, imaging techniques and systems biology, and includes leaders of diabetes and kidney disease-relevant
IMI1, FP7 and US consortia, like SUMMIT, KIDNEYCONNECT, Syskid, CPROBE and C-Path, in an unprecedented search for new and better biomarkers for DKD, through a better understanding of the disease.
Jointly, the partners have access to vast and very relevant clinical cohorts and trials, state-of-the-art analysis and imaging techniques, novel model systems and the long-standing experience and networks to make this collaboration a success. By involving regulatory agencies throughout the project, BEAt-DKD aims at making the introduction and acceptance of new tools as efficient as possible.
The overall goals of BEAt-DKD are (1) to provide a holistic systems medicine view of the pathogenesis of DKD with the aim to identify targetable mechanisms and pathways underlying initiation and progression of DKD, applying a novel sub-classification of diabetes, and (2) to identify and validate biomarkers of disease progression and treatment responses representing first steps towards precision medicine in the management of DKD.
Fields of science
Programme(s)
Funding Scheme
IMI2-RIA - Research and Innovation actionCoordinator
22100 Lund
Sweden
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Participants (37)
00014 Helsingin Yliopisto
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9713 GZ Groningen
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OX1 2JD Oxford
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70211 Kuopio
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DD1 4HN Dundee
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EX4 4QJ Exeter
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20156 Milano
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20014 Turku
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
20520 Turku
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79106 Freiburg
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BS8 1QU Bristol
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LS2 9JT Leeds
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
LS9 7TF Leeds
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HU6 7RX Hull
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33404 Talence
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91054 Erlangen
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6020 Innsbruck
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93053 Regensburg
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1090 Wien
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70121 Bari
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
70010 Valenzano
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
70124 Bari
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01307 Dresden
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
46109 1274 Ann Arbor
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1206 Geneve
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10004 New York
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60064 North Chicago Il
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65929 Frankfurt Am Main
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2333 BE Leiden
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RG21 4FA Basingstoke
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13353 Berlin
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2880 Bagsvaerd
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55218 Ingelheim
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20251 Hamburg
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431 83 Molndal
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
S10 2TN Sheffield
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51373 Leverkusen
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