Objective
Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD), and its global incidence and prevalence have reached epidemic dimensions in recent years. Unfortunately, there are no effective means to prevent or cure DKD, the few existing treatments have limited effect and very few alternative therapies have emerged in the past years. Lack of new predictive and prognostic biomarkers for a more accurate patient stratification, limited access to kidney tissue from patients at various stages of DKD as well as novel model systems to better understand the pathogenesis of the disease, are likely reasons for the stagnating development of new treatments.
The BEAt-DKD consortium combines outstanding basic and translational researchers in nephropathy, diabetes, kidney model systems, imaging techniques and systems biology, and includes leaders of diabetes and kidney disease-relevant
IMI1, FP7 and US consortia, like SUMMIT, KIDNEYCONNECT, Syskid, CPROBE and C-Path, in an unprecedented search for new and better biomarkers for DKD, through a better understanding of the disease.
Jointly, the partners have access to vast and very relevant clinical cohorts and trials, state-of-the-art analysis and imaging techniques, novel model systems and the long-standing experience and networks to make this collaboration a success. By involving regulatory agencies throughout the project, BEAt-DKD aims at making the introduction and acceptance of new tools as efficient as possible.
The overall goals of BEAt-DKD are (1) to provide a holistic systems medicine view of the pathogenesis of DKD with the aim to identify targetable mechanisms and pathways underlying initiation and progression of DKD, applying a novel sub-classification of diabetes, and (2) to identify and validate biomarkers of disease progression and treatment responses representing first steps towards precision medicine in the management of DKD.
Field of science
- /medical and health sciences/clinical medicine/endocrinology/diabetes
- /medical and health sciences/clinical medicine/nephrology
Call for proposal
H2020-JTI-IMI2-2015-05-two-stage
See other projects for this call
Funding Scheme
IMI2-RIA - Research and Innovation actionCoordinator
22100 Lund
Sweden
Participants (30)
00014 Helsingin Yliopisto
9713 GZ Groningen
OX1 2JD Oxford
70211 Kuopio
DD1 4HN Dundee
EX4 4QJ Exeter
20156 Milano
20014 Turku
79106 Freiburg
BS8 1QU Bristol
LS2 9JT Leeds
HU6 7RX Hull
33404 Talence
91054 Erlangen
6020 Innsbruck
93053 Regensburg
1090 Wien
70121 Bari
01307 Dresden
46109 1274 Ann Arbor
1206 Geneve
10004 New York
60064 North Chicago Il
65929 Frankfurt Am Main
2333 BE Leiden
RG24 9NL Basingstoke
13353 Berlin
2880 Bagsvaerd
55218 Ingelheim
20251 Hamburg