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Biomarker Enterprise to Attack DKD - Sofia ref.: 115974

Objective

Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD), and its global incidence and prevalence have reached epidemic dimensions in recent years. Unfortunately, there are no effective means to prevent or cure DKD, the few existing treatments have limited effect and very few alternative therapies have emerged in the past years. Lack of new predictive and prognostic biomarkers for a more accurate patient stratification, limited access to kidney tissue from patients at various stages of DKD as well as novel model systems to better understand the pathogenesis of the disease, are likely reasons for the stagnating development of new treatments.

The BEAt-DKD consortium combines outstanding basic and translational researchers in nephropathy, diabetes, kidney model systems, imaging techniques and systems biology, and includes leaders of diabetes and kidney disease-relevant
IMI1, FP7 and US consortia, like SUMMIT, KIDNEYCONNECT, Syskid, CPROBE and C-Path, in an unprecedented search for new and better biomarkers for DKD, through a better understanding of the disease.

Jointly, the partners have access to vast and very relevant clinical cohorts and trials, state-of-the-art analysis and imaging techniques, novel model systems and the long-standing experience and networks to make this collaboration a success. By involving regulatory agencies throughout the project, BEAt-DKD aims at making the introduction and acceptance of new tools as efficient as possible.

The overall goals of BEAt-DKD are (1) to provide a holistic systems medicine view of the pathogenesis of DKD with the aim to identify targetable mechanisms and pathways underlying initiation and progression of DKD, applying a novel sub-classification of diabetes, and (2) to identify and validate biomarkers of disease progression and treatment responses representing first steps towards precision medicine in the management of DKD.

Field of science

  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /medical and health sciences/clinical medicine/nephrology

Call for proposal

H2020-JTI-IMI2-2015-05-two-stage
See other projects for this call

Funding Scheme

IMI2-RIA - Research and Innovation action

Coordinator

LUNDS UNIVERSITET
Address
Paradisgatan 5C
22100 Lund
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 110 937

Participants (30)

HELSINGIN YLIOPISTO
Finland
EU contribution
€ 800 000
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 2 100 000
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 900 000
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 200 000
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF DUNDEE
United Kingdom
EU contribution
€ 655 000
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
€ 555 000
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter
Activity type
Higher or Secondary Education Establishments
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 150 000
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
TURUN YLIOPISTO
Finland
EU contribution
€ 320 000
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM FREIBURG
Germany
EU contribution
€ 70 000
Address
Hugstetter Strasse 49
79106 Freiburg
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 500 000
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 860 000
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF HULL
United Kingdom
EU contribution
€ 250 000
Address
Cottingham Road
HU6 7RX Hull
Activity type
Higher or Secondary Education Establishments
CHU HOPITAUX DE BORDEAUX
France
EU contribution
€ 460 000
Address
Rue Dubernat 12
33404 Talence
Activity type
Higher or Secondary Education Establishments
UNIVERSITATSKLINIKUM ERLANGEN
Germany
EU contribution
€ 500 000
Address
Maximiliansplatz 2
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 895 000
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
KLINIKUM DER UNIVERSITAET REGENSBURG
Germany
EU contribution
€ 360 000
Address
Frans Josef Strauss Allee 11
93053 Regensburg
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 950 000
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy
EU contribution
€ 620 000
Address
Piazza Umberto I 1
70121 Bari
Activity type
Higher or Secondary Education Establishments
LIPOTYPE
Germany
EU contribution
€ 300 000
Address
Tatzberg 47
01307 Dresden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY OF MICHIGAN THE REGENTS OF THE UNIVERSITY OF MICHIGAN
United States
EU contribution
€ 0
Address
South Street 3003 1068
46109 1274 Ann Arbor
Activity type
Higher or Secondary Education Establishments
SIB INSTITUT SUISSE DE BIOINFORMATIQUE
Switzerland
EU contribution
€ 0
Address
Rue Michel Servet 1 Cmu
1206 Geneve
Activity type
Research Organisations
JDRF INTERNATIONAL
United States
EU contribution
€ 0
Address
26 Broadway 14Th Floor
10004 New York
Activity type
Research Organisations
ABBVIE INC
United States
EU contribution
€ 0
Address
North Waukegan Road 1
60064 North Chicago Il
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI-AVENTIS DEUTSCHLAND GMBH
Germany
EU contribution
€ 0
Address
Bruningstrasse 50
65929 Frankfurt Am Main
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASTELLAS PHARMA EUROPE BV
Netherlands
EU contribution
€ 0
Address
Sylviusweg 84
2333 BE Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Eli Lilly and Company Limited
United Kingdom
EU contribution
€ 0
Address
Lilly House, Priestley Road
RG24 9NL Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Bayer Pharma AG
Germany
EU contribution
€ 0
Address
Muellerstrasse 178
13353 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVO NORDISK A/S
Denmark
EU contribution
€ 0
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
EU contribution
€ 0
Address
Binger Strasse
55218 Ingelheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 1 530 000
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments