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Alzheimers Disease Apolipoprotein Pathology for Treatment Elucidation and Development - Sofia ref.: 115975

Objective

APOEɛ4 has long been known as a risk factor of LOAD, yet the biological mechanisms through which it acts remain largely unknown and affect both the vasculature and the brain. This complexity and pleiotropic influence demands an integrated hypothesis-free approach to embark on a fundamental study of the gene, the phenotype and modulation by other risk factors. ADAPTED proposes to leverage extreme genotypes from consortium cohorts dating back more than 25 years to generate, and use existing, lines of human induced pluripotent stem cells (iPSC). These cells, with blood cells, will form the backbone of the research programme. We will differentiate them to the most relevant cells for APOE and AD studies and with gene editing create bespoke homozygote ɛ3 and ɛ2 cells for a highly focussed effort on APOE biology. A series of experiments including neuron-astrocyte and macrophage-endothelium co-culture and Organ on a Chip models combined with state-of-the-art omics including quantitative proteomics assays will generate data for rigorous integrated analysis to uncover new signalling pathways related to APOE. Lipid homeostasis, endocytosis, metabolism and immune systems pathways will be investigated in a broad approach. The findings are expected to lead to identification of new treatment approaches and blood based AD signatures with a temporal dimension from the earliest stages of risk identification and progression through MCI to AD. Testing and validation of biomarkers will be performed by examining their influence and predictive capacity in a longitudinal ADAPTED cohort harmonised using a combination of approaches for marker and diagnostic consistency. The impact of this work can be expected to include seminal new finding to illuminate the research path towards new diagnostics and therapies to attenuate the rising tide of suffering from AD. The vision is a follow on with clinical proof of concept validating utility of the results within two years of the end of ADAPTED.

Coordinator

FUNDACIO ACE
Net EU contribution
€ 333 757,00
Address
Marques De Sentmenat 57
08014 Barcelona
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 100 000,00

Participants (13)

ABBVIE DEUTSCHLAND GMBH & CO KG
Germany
Net EU contribution
€ 0,00
Address
Mainzer Str. 81
65205 Wiesbaden

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Region
Darmstadt Wiesbaden, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 1 786 740,00
BIOGEN IDEC LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Innovation House 70 Norden Road
SL6 3AY Maidenhead

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Berkshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 320 248,00
CAEBI BIOINFORMATICA SOCIEDAD LIMITADA
Spain
Net EU contribution
€ 282 062,00
Address
Rio De La Plata 2 Bajo 4
41013 Sevilla

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Andalucía Sevilla
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Net EU contribution
€ 688 476,00
Address
Calle Serrano 117
28006 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Other funding
€ 0,00
DC BIOSCEINCES LTD
United Kingdom
Net EU contribution
€ 186 514,00
Address
James Lindsay Place 3 Dundee Technopole
DD1 5JJ Dundee

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Eastern Scotland Angus and Dundee City
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 185 752,25
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 420 500,00
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
JANSSEN PHARMACEUTICA NV
Belgium
Net EU contribution
€ 0,00
Address
Turnhoutseweg 30
2340 Beerse

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Region
Vlaams Gewest Prov. Antwerpen Arr. Turnhout
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 750 000,00
KITE INNOVATION (EUROPE) LIMITED

Participation ended

United Kingdom
Net EU contribution
€ 37 912,66
Address
3m Buckley Innovation Centre
HD1 3BD Huddersfield
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Yorkshire and the Humber West Yorkshire Calderdale and Kirklees
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 9,00
UNIVERSITEIT LEIDEN
Netherlands
Net EU contribution
€ 470 677,00
Address
Rapenburg 70
2311 EZ Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Other funding
€ 100 000,00
MIMETAS BV
Netherlands
Net EU contribution
€ 305 102,00
Address
De Limes 7
2342 DH Oegstgeest

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UNIVERSITATSKLINIKUM BONN
Germany
Net EU contribution
€ 429 850,00
Address
Venusberg-campus 1
53127 Bonn

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Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
Net EU contribution
€ 244 812,00
Address
Kerpener Strasse 62
50937 Koeln

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Region
Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
MODUS RESEARCH AND INNOVATION LIMITED
United Kingdom
Net EU contribution
€ 110 337,34
Address
7-11 Melville Street
EH3 7PE Edinburgh

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Eastern Scotland Edinburgh
Activity type
Research Organisations
Other funding
€ 43 990,75