Obiettivo It has been estimated a threefold increase in the number of obese people in Europe since the 1980’s. Currently, EUcountries spend an average of 7% of their public health budgets on diseases linked to obesity. The socio-economic impact ofobesity epidemic cannot be overrated. European societal needs require desperately a shift forward in the field of obesityresearch to be able to build new therapeutics strategies. Recent scientific evidences point toward a role of epigeneticchanges as major contributor in the obesity etiology. In the last decades, a huge amount of data clearly link epigeneticdysregulation to obesity onset. Yet, it remains unclear whether epigenetic dysregulation contributes meaningfully to obesityepidemic. Because weight gain only occurs when energy intake exceed energy expenditure, burning off excess fuelrepresent an attractive path to reduce obesity when diet and exercise are not enough. My preliminary data indicate thehistone methyltransferases Suv420h1 and Suv420h2 as pivotal players in metabolism regulation. By using knockout micespecifically in brown adipose tissue, this project aims at dissecting the role of Suv420h proteins in the etiology ofobesity. I will combine in vivo and in vitro analyses and genome wide studies to: 1) dissect the role of Suv420h proteinsin the epigenetic regulation of the pathways controlling weight balance in response to nutritional or environmental stimuli; 2) identify genes involved in the generation, maintenance or transmission of the epigenetic memory of exposure; 3) provide useful markers or therapeutic targets to treat obesity and metabolic diseases. My results have the potential to translate into therapeutics. This research will contribute to provide new clinical targets against obesity. The Experienced Researcher will emerge from the project with new skills, and the capability to lead her own research group. Campo scientifico medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymesmedical and health scienceshealth sciencesnutritionobesitynatural sciencesbiological sciencesgeneticsepigenetics Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2016 - Individual Fellowships Invito a presentare proposte H2020-MSCA-IF-2016 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF-EF-SE - Society and Enterprise panel Coordinatore OSPEDALE SAN RAFFAELE SRL Contribution nette de l'UE € 168 277,20 Indirizzo VIA OLGETTINA 60 20132 Milano Italia Mostra sulla mappa Regione Nord-Ovest Lombardia Milano Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 168 277,20