Obiettivo The prevalence of diabetes is continuously rising even in low-income economies. Therefore, blood glucose monitoring tools are in high social demand globally. Uninterrupted monitoring of blood glucose is a must in order to keep the fatal levels of glycated hemoglobin under control and to improve the quality of life for diabetic patients. However, glucose monitoring is compromised by the painful finger pricking about 4-5 times a day to obtain blood samples which leads to patient non-compliance and hence endangering their lifes.The main objective of NANOTEARS is the development of a non-invasive diabetes diagnostic tool by detecting in vitro ocular glucose that is ready to be integrated in a smartphone for point of care and homecare use. Compared to other body fluids, tears are more accessible than blood or interstitial fluid, more continuously obtainable, and less susceptible to dilution. So, it is a worthwhile alternative to finger pricking for repetitive monitoring. Additionally, the use of a cell phone enables systematically collection and management of glucose level records in electronic form in order to reduce medical errors and improve quality of care and promote evidence-based medicine. Our sensing strategy is based on the use of fluorescent spectroscopy. Taking into account, that glucose concentration in tear fluid is about 50-100 lower than the glucose in blood there is a need to enhace the emitted signal to meet the accuracy and tolerance as recommended in the ISO 15197:2013. To reach this goal, we will fabricate highly fluorescent nanocomposite consisting of functionalized carbon quantum dots embedded into mesoporous silica. The entire synthesis will be performed without the need to use residual chemical precursors and stabilizers allowing for “green synthesis”, owing to the use laser ablation in liquids. The use of femtosecond disruptive technology will enable to circumvent the limitations imposed by the low speeds at which nanoparticles are ablated. Campo scientifico medical and health sciencesclinical medicineendocrinologydiabetesengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsengineering and technologyelectrical engineering, electronic engineering, information engineeringinformation engineeringtelecommunicationsmobile phonesengineering and technologynanotechnologynano-materialsnatural sciencesphysical sciencesopticsspectroscopy Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2016 - Individual Fellowships Invito a presentare proposte H2020-MSCA-IF-2016 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF-EF-ST - Standard EF Coordinatore UNIVERSITAT JAUME I DE CASTELLON Contribution nette de l'UE € 170 121,60 Indirizzo AVENIDA VICENT SOS BAYNAT S/N 12006 Castellon De La Plana Spagna Mostra sulla mappa Regione Este Comunitat Valenciana Castellón/Castelló Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 170 121,60