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Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797

Objective

Preclinical type 1 diabetes (T1D) research has made important advances in recent years, but less progress has been made in translating findings from in vitro and animal models into effective clinical interventions. INNODIA aims to achieve a breakthrough in the way in which we study T1D to enable us to move closer towards prevention and cure of T1D. To this end, INNODIA joins together the leading European experts from the fields of basic and clinical T1D research, four leading pharmaceutical companies with strong expertise in the discovery and development of diabetes medicines and the two leading public organizations involved in T1D research into one comprehensive collaborative consortium. The clinicians in INNODIA oversee T1D registries and have access to large populations of children and adults with T1D and family members at increased risk of developing the disease. The basic science researchers are experts in beta-cell pathophysiology, immunology, biomarker discovery, bioinformatics, systems biology and clinical trial design. INNODIA will accelerate understanding of T1D through coordinated studies of unique clinical samples and translation-oriented preclinical models. This should deliver novel biomarkers and interventions for testing in appropriately designed trials, to be developed in active collaboration with regulators and patients. INNODIA provides access to unique historical biorepositories and will create the Clinical Sample Network, a clinical EU infrastructure to recruit T1D subjects at diagnosis and at-risk relatives. These individuals will be deep-phenotyped and will provide biosamples, allowing the establishment of a ‘living biobank’ of subjects consented for recall. They will be characterized using standardized clinical, genetic and metabolic phenotyping procedures, including prospective, longitudinal sample collection to facilitate novel biomarker discovery. Diverse biological samples (blood, plasma, serum, urine, stools, etc.) will be collected at

Call for proposal

H2020-JTI-IMI2-2014-01-two-stage
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Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Address
Oude Markt 13
3000 Leuven
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 302 642,79

Participants (42)

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 1 945 738,96
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAT GRAZ
Austria
EU contribution
€ 352 526
Address
Auenbruggerplatz 2
8036 Graz
Activity type
Higher or Secondary Education Establishments
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 657 905,25
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 1 060 600
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
REGION HOVEDSTADEN
Denmark
EU contribution
€ 995 063
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 1 866 869,99
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 800 561
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
OULUN YLIOPISTO
Finland
EU contribution
€ 431 700
Address
Pentti Kaiteran Katu 1
90014 Oulu
Activity type
Higher or Secondary Education Establishments
TURUN YLIOPISTO
Finland
EU contribution
€ 572 050
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
HANNOVERSCHE KINDERHEILANSTALT
Germany
EU contribution
€ 645 830
Address
Janusz Korczak Allee 12
30173 Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 362 276
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 1 160 045
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET ULM
Germany
EU contribution
€ 281 380
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 726 497,27
Address
Via Banchi Di Sotto 55
53100 Siena
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA
Italy
EU contribution
€ 46 404,06
Address
Via Dei Vestini 31
66013 Chieti
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DI PISA
Italy
EU contribution
€ 455 066
Address
Lungarno Pacinotti 43/44
56126 Pisa
Activity type
Higher or Secondary Education Establishments
CENTRE HOSPITALIER DE LUXEMBOURG
Luxembourg
EU contribution
€ 284 650
Address
Rue Nicolas Ernest Barble 4
1210 Luxembourg
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
UNIVERSITETET I OSLO

Participation ended

Norway
EU contribution
€ 3 763
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH
Poland
EU contribution
€ 291 200
Address
Ul. Poniatowskiego 15
40 055 Katowice
Activity type
Higher or Secondary Education Establishments
UNIVERZA V LJUBLJANI
Slovenia
EU contribution
€ 287 358
Address
Kongresni Trg 12
1000 Ljubljana
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 0
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
STICHTING RADBOUD UNIVERSITEIT

Participation ended

Netherlands
EU contribution
€ 367 532,41
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 542 244,50
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 348 616,63
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
UNITED KINGDOM RESEARCH AND INNOVATION

Participation ended

United Kingdom
EU contribution
€ 19 423
Address
Polaris House North Star Avenue
SN2 1FL Swindon
Activity type
Research Organisations
HUMAN CELL DESIGN
France
EU contribution
€ 373 877,50
Address
Place Pierre Potier Centre Pierre Potier Canceropole Entree B 1
31000 Toulouse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI-AVENTIS DEUTSCHLAND GMBH
Germany
EU contribution
€ 0
Address
Bruningstrasse 50
65929 Frankfurt Am Main
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVO NORDISK A/S
Denmark
EU contribution
€ 0
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
EU contribution
€ 0
Address
Great West Road 980
TW89GS Brentford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ELI LILLY AND COMPANY LTD
United Kingdom
EU contribution
€ 0
Address
Lilly House Basingview
RG21 4FA Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JDRF INTERNATIONAL
United States
EU contribution
€ 0
Address
26 Broadway 14Th Floor
10004 New York
Activity type
Research Organisations
THE LEONA M. AND HARRY B. HELMSLEY CHARITABLE TRUST
United States
EU contribution
€ 0
Address
230 Park Avenue Suite 659
10169 New York
Activity type
Other
OSLO UNIVERSITETSSYKEHUS HF
Norway
EU contribution
€ 422 401
Address
Kirkeveien 166 Tarnbygget
0450 Oslo
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 111 000
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 384 316,05
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
EU contribution
€ 130 540
Address
Via Olgettina 58
20132 Milano
Activity type
Higher or Secondary Education Establishments
NOVARTIS PHARMA AG
Switzerland
EU contribution
€ 0
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IMCYSE SA
Belgium
EU contribution
€ 0
Address
Avenue De L Hopital 1 Giga B34
4000 Sart Tilman
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
€ 50 000
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter
Activity type
Higher or Secondary Education Establishments
LUNDS UNIVERSITET
Sweden
EU contribution
€ 136 850
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
OSPEDALE PEDIATRICO BAMBINO GESU
Italy
EU contribution
€ 157 050
Address
Piazza Sant Onofrio 4
00165 Roma
Activity type
Research Organisations
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands
EU contribution
€ 56 022,59
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen
Activity type
Higher or Secondary Education Establishments