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Program for Innovative Global Prevention of Streptococcus suis.

Objective

Streptococcus suis is an endemic porcine disease causing causing significant economic losses to the pork meat production industry in all countries where pigs are reared on a large scale. In some countries S. suis is the primary cause of mortality and morbidity in young pigs and the most frequent reason to prescribe antibiotics of the amino-penicillin group as a preventative measure. S. suis is also a zoonotic pathogen of humans and infections reported worldwide has increased significantly in the past years. Within S. suis many different types (serotypes, genotypes, pathotypes) exist causing problems in the development of control strategies targeting all types. Asymptomatic carriage in adult pigs is common and combined with a lack of knowledge on the host-pathogen-environment interactions, are the main reasons for failure to control the endemic nature of this pathogen. The project outputs will impact on on understanding host-pathogen-environment interactions of S. suis infections through the genome sequencing of 1200-1500 S. suis isolates from representative geographic areas of the major pork producing countries and performing genome-wide-association studies with invasive disease and asymptomatic carriage. New diagnostic methods will be developed for global monitoring of infection risk and tested on case-farms. Epidemiology studies will determine risk factors for invasive S. suis disease, including the role of co-infections, and for the first time properly assess the dynamics of the disease on a representative farm. We will increase our understanding of the virulence mechanisms involved in pathogenesis including interactions of S. suis with the innate immune system. The project outputs will strengthen the evidence base for prevention and control strategies through testing of novel conserved vaccine antigens in pigs and prevention strategies based on manipulation of the microbiota and stimulation and maturation of the innate immune system.

Field of science

  • /social sciences/sociology/demography/mortality
  • /medical and health sciences/basic medicine/immunology
  • /natural sciences/biological sciences/genetics and heredity/genome
  • /medical and health sciences/health sciences/epidemiology

Call for proposal

H2020-SFS-2016-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

WAGENINGEN UNIVERSITY
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 153 795

Participants (8)

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 1 030 667,50
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
STICHTING WAGENINGEN RESEARCH
Netherlands
EU contribution
€ 799 998,75
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Research Organisations
CEVA SANTE ANIMALE SA
France
EU contribution
€ 150 625
Address
Avenue De La Ballastiere 10
33500 Libourne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT DE RECERCA I TECNOLOGIA AGROALIMENTARIES
Spain
EU contribution
€ 698 981,25
Address
Ctra C-59 Km 12 Torre Marimon
08140 Caldes De Montbui Barcelona
Activity type
Other
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 365 146,25
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 292 765
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 408 000
Address
Bunteweg 2
30559 Hannover
Activity type
Higher or Secondary Education Establishments
CHR. HANSEN A/S
Denmark
EU contribution
€ 98 125
Address
Boege Alle 10-12
2970 Hoersholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)