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Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing behaviours

Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing behaviours

Ziel

Maladaptive impulsivity and compulsivity predispose to antisocial and addictive behaviours. Factors influencing those traits are not well understood, but diet, lifestyle, socio-economic status (SES), sex, and heritability play pivotal roles. Here, we aim (1) to identify nutrition and lifestyle drivers that can be employed to prevent detrimental impulsivity/compulsivity in males and females across the lifespan, (2) to characterize the etiologic paths leading to extreme behaviour, and (3) to promote policy changes to counteract maladaptive impulsivity/compulsivity by disseminating evidence-based information about health-related behaviours to families, clinicians, policy makers, and general public. We use epidemiologic approaches in the world-wide largest existing samples to investigate association of nutrition components & lifestyle with impulsivity/ compulsivity, and how such associations are moderated by age, culture, sex, SES, and genetics. We assess beneficial effects of key nutritional interventions through RCTs in highly impulsive males/females, going beyond state-of-the-art by directly comparing personalized, high-intensity approaches with one-size-fits-all and microbiome-dependent supplementations. We study the protective potential of acute exercise and habitual physical activity. We monitor intervention-induced changes in real time through objective mHealth-based experience sampling. Uniquely, we study effects of the gut-microbiome and its metabolites, as well as brain connectivity and epigenetic patterns as mediators and predictors of behavioural change. We initiate and support societal change by media-based information and education. We innovate the field by measuring behavioural change using social media downstream of educational campaigns and by translation of our findings into tangible healthy food solutions with a celebrity chef. Our group, in which experts from multiple disciplines join forces, is in a unique position to carry out the proposed project.
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STICHTING KATHOLIEKE UNIVERSITEIT

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Geert Grooteplein Noord 9
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Niederlande

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€ 3 280 171,25

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STICHTING KARAKTER

Niederlande

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JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN

Deutschland

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€ 727 962

UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT

Deutschland

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€ 569 728,50

UNIVERSITAT DE BARCELONA

Spanien

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€ 94 170

FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA

Spanien

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€ 479 789,91

UNIVERSITETET I BERGEN

Norwegen

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TARTU ULIKOOL

Estland

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€ 235 425

ACADEMISCH ZIEKENHUIS GRONINGEN

Niederlande

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ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT

Deutschland

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€ 540 347,39

WAGENINGEN UNIVERSITY

Niederlande

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€ 1 293 951,25

Concentris Research Management GmbH

Deutschland

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€ 423 765

OREBRO UNIVERSITY

Schweden

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€ 279 331,25

SEMMELWEIS EGYETEM

Ungarn

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€ 94 170

CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.

Spanien

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€ 423 764,95

KARLSRUHER INSTITUT FUER TECHNOLOGIE

Deutschland

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STICHTING BURO ECNP

Niederlande

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€ 23 542

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Vereinigtes Königreich

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€ 47 084,76

Projektinformationen

ID Finanzhilfevereinbarung: 728018

Status

Laufendes Projekt

  • Startdatum

    1 September 2017

  • Enddatum

    31 August 2022

Finanziert unter:

H2020-EU.3.2.2.2.

  • Gesamtbudget:

    € 11 148 189,76

  • EU-Beitrag

    € 11 144 561,76

Koordiniert durch:

STICHTING KATHOLIEKE UNIVERSITEIT

Niederlande