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Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing behaviours

Objective

Maladaptive impulsivity and compulsivity predispose to antisocial and addictive behaviours. Factors influencing those traits are not well understood, but diet, lifestyle, socio-economic status (SES), sex, and heritability play pivotal roles. Here, we aim (1) to identify nutrition and lifestyle drivers that can be employed to prevent detrimental impulsivity/compulsivity in males and females across the lifespan, (2) to characterize the etiologic paths leading to extreme behaviour, and (3) to promote policy changes to counteract maladaptive impulsivity/compulsivity by disseminating evidence-based information about health-related behaviours to families, clinicians, policy makers, and general public. We use epidemiologic approaches in the world-wide largest existing samples to investigate association of nutrition components & lifestyle with impulsivity/ compulsivity, and how such associations are moderated by age, culture, sex, SES, and genetics. We assess beneficial effects of key nutritional interventions through RCTs in highly impulsive males/females, going beyond state-of-the-art by directly comparing personalized, high-intensity approaches with one-size-fits-all and microbiome-dependent supplementations. We study the protective potential of acute exercise and habitual physical activity. We monitor intervention-induced changes in real time through objective mHealth-based experience sampling. Uniquely, we study effects of the gut-microbiome and its metabolites, as well as brain connectivity and epigenetic patterns as mediators and predictors of behavioural change. We initiate and support societal change by media-based information and education. We innovate the field by measuring behavioural change using social media downstream of educational campaigns and by translation of our findings into tangible healthy food solutions with a celebrity chef. Our group, in which experts from multiple disciplines join forces, is in a unique position to carry out the proposed project.

Call for proposal

H2020-SFS-2016-2017

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Sub call

H2020-SFS-2016-2

Coordinator

STICHTING RADBOUD UNIVERSITEIT
Net EU contribution
€ 3 378 710,00
Address
Houtlaan 4
6525 XZ Nijmegen
Netherlands

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 3 378 710,00

Participants (19)

STICHTING KARAKTER
Netherlands
Net EU contribution
€ 1 026 598,50
Address
Horalaan 5
6717 LX Ede

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Region
Oost-Nederland Gelderland Veluwe
Activity type
Other
Other funding
€ 1 026 598,50
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
Net EU contribution
€ 727 962,00
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 727 962,00
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
Net EU contribution
€ 569 728,50
Address
Josef-schneider-strasse 2
97080 Wurzburg

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Region
Bayern Unterfranken Würzburg, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 569 728,50
UNIVERSITAT DE BARCELONA
Spain
Net EU contribution
€ 94 170,00
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Other funding
€ 94 170,00
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
Net EU contribution
€ 479 789,91
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 479 789,91
UNIVERSITETET I BERGEN
Norway
Net EU contribution
€ 404 535,00
Address
Museplassen 1
5020 Bergen

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Region
Norge Vestlandet Vestland
Activity type
Higher or Secondary Education Establishments
Other funding
€ 404 535,00
TARTU ULIKOOL
Estonia
Net EU contribution
€ 235 425,00
Address
Ulikooli 18
51005 Tartu

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Region
Eesti Eesti Lõuna-Eesti
Activity type
Higher or Secondary Education Establishments
Other funding
€ 235 425,00
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
Net EU contribution
€ 375 223,75
Address
Hanzeplein 1
9713 GZ Groningen

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 375 223,75
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

STICHTING UNIVERSITAIRE EN ALGEMENE KINDER - EN JEUGDPSYCHIATRIE NOORD-NEDERLAND
Netherlands
Net EU contribution
€ 481 621,25
Address
Beilerstraat 173
9401 PJ Assen

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Region
Noord-Nederland Drenthe Noord-Drenthe
Activity type
Other
Other funding
€ 481 621,25
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Germany
Net EU contribution
€ 540 347,39
Address
Square J 5
68159 Mannheim

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Region
Baden-Württemberg Karlsruhe Mannheim, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 540 347,39
WAGENINGEN UNIVERSITY
Netherlands
Net EU contribution
€ 1 293 951,25
Address
Droevendaalsesteeg 4
6708 PB Wageningen

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Region
Oost-Nederland Gelderland Veluwe
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 293 951,25
CONCENTRIS RESEARCH MANAGEMENT GMBH
Germany
Net EU contribution
€ 423 765,00
Address
Ludwigstr. 4
82256 Furstenfeldbruck

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Oberbayern Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 423 765,00
OREBRO UNIVERSITY
Sweden
Net EU contribution
€ 279 331,25
Address
Fakultetsgatan 1
70182 Orebro

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Region
Östra Sverige Östra Mellansverige Örebro län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 279 331,25
SEMMELWEIS EGYETEM
Hungary
Net EU contribution
€ 94 170,00
Address
Ulloi Utca 26
1085 Budapest

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Region
Közép-Magyarország Budapest Budapest
Activity type
Higher or Secondary Education Establishments
Other funding
€ 94 170,00
CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.
Spain
Net EU contribution
€ 340 077,45
Address
Calle Monforte De Lemos 5
28029 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Other funding
€ 340 077,45
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA PERE VIRGILI (IISPV)
Spain
Net EU contribution
€ 83 687,50
Address
Carrer Escorxador
43003 Tarragona

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Region
Este Cataluña Tarragona
Activity type
Research Organisations
Other funding
€ 83 687,50
KARLSRUHER INSTITUT FUER TECHNOLOGIE
Germany
Net EU contribution
€ 244 841,25
Address
Kaiserstrasse 12
76131 Karlsruhe

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Region
Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 244 841,25
STICHTING BURO ECNP
Netherlands
Net EU contribution
€ 23 542,00
Address
Daltonlaan 400
3584 BK Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Other
Other funding
€ 23 542,00
ADD INFORMATION SERVICES
United Kingdom
Net EU contribution
€ 47 084,76
Address
10th Floor, Hyde House, Colindale
NW9 6LH London

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Region
London Outer London — West and North West Barnet
Activity type
Other
Other funding
€ 47 084,76