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Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing behaviours

Objective

Maladaptive impulsivity and compulsivity predispose to antisocial and addictive behaviours. Factors influencing those traits are not well understood, but diet, lifestyle, socio-economic status (SES), sex, and heritability play pivotal roles. Here, we aim (1) to identify nutrition and lifestyle drivers that can be employed to prevent detrimental impulsivity/compulsivity in males and females across the lifespan, (2) to characterize the etiologic paths leading to extreme behaviour, and (3) to promote policy changes to counteract maladaptive impulsivity/compulsivity by disseminating evidence-based information about health-related behaviours to families, clinicians, policy makers, and general public. We use epidemiologic approaches in the world-wide largest existing samples to investigate association of nutrition components & lifestyle with impulsivity/ compulsivity, and how such associations are moderated by age, culture, sex, SES, and genetics. We assess beneficial effects of key nutritional interventions through RCTs in highly impulsive males/females, going beyond state-of-the-art by directly comparing personalized, high-intensity approaches with one-size-fits-all and microbiome-dependent supplementations. We study the protective potential of acute exercise and habitual physical activity. We monitor intervention-induced changes in real time through objective mHealth-based experience sampling. Uniquely, we study effects of the gut-microbiome and its metabolites, as well as brain connectivity and epigenetic patterns as mediators and predictors of behavioural change. We initiate and support societal change by media-based information and education. We innovate the field by measuring behavioural change using social media downstream of educational campaigns and by translation of our findings into tangible healthy food solutions with a celebrity chef. Our group, in which experts from multiple disciplines join forces, is in a unique position to carry out the proposed project.

Call for proposal

H2020-SFS-2016-2
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Coordinator

STICHTING RADBOUD UNIVERSITEIT
Address
Houtlaan 4
6525 XZ Nijmegen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 280 171,25

Participants (17)

STICHTING KARAKTER
Netherlands
EU contribution
€ 1 026 598,50
Address
Horalaan 5
6717 LX Ede
Activity type
Other
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
EU contribution
€ 727 962
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
EU contribution
€ 569 728,50
Address
Josef-schneider-strasse 2
97080 Wurzburg
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT DE BARCELONA
Spain
EU contribution
€ 94 170
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Activity type
Higher or Secondary Education Establishments
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
EU contribution
€ 479 789,91
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona
Activity type
Research Organisations
UNIVERSITETET I BERGEN
Norway
EU contribution
€ 404 535
Address
Museplassen 1
5007 Bergen
Activity type
Higher or Secondary Education Establishments
TARTU ULIKOOL
Estonia
EU contribution
€ 235 425
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 955 383,75
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Germany
EU contribution
€ 540 347,39
Address
Square J 5
68159 Mannheim
Activity type
Higher or Secondary Education Establishments
WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 1 293 951,25
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
Concentris Research Management GmbH
Germany
EU contribution
€ 423 765
Address
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OREBRO UNIVERSITY
Sweden
EU contribution
€ 279 331,25
Address
Fakultetsgatan 1
70182 Orebro
Activity type
Higher or Secondary Education Establishments
SEMMELWEIS EGYETEM
Hungary
EU contribution
€ 94 170
Address
Ulloi Utca 26
1085 Budapest
Activity type
Higher or Secondary Education Establishments
CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.
Spain
EU contribution
€ 423 764,95
Address
Calle Monforte De Lemos 5
28029 Madrid
Activity type
Research Organisations
KARLSRUHER INSTITUT FUER TECHNOLOGIE
Germany
EU contribution
€ 244 841,25
Address
Kaiserstrasse 12
76131 Karlsruhe
Activity type
Higher or Secondary Education Establishments
STICHTING BURO ECNP
Netherlands
EU contribution
€ 23 542
Address
Daltonlaan 400
3584 BK Utrecht
Activity type
Other
ADD INFORMATION SERVICES
United Kingdom
EU contribution
€ 47 084,76
Address
10Th Floor, Hyde House, Colindale
NW9 6LH London
Activity type
Other