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Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing behaviours

Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing behaviours

Objective

Maladaptive impulsivity and compulsivity predispose to antisocial and addictive behaviours. Factors influencing those traits are not well understood, but diet, lifestyle, socio-economic status (SES), sex, and heritability play pivotal roles. Here, we aim (1) to identify nutrition and lifestyle drivers that can be employed to prevent detrimental impulsivity/compulsivity in males and females across the lifespan, (2) to characterize the etiologic paths leading to extreme behaviour, and (3) to promote policy changes to counteract maladaptive impulsivity/compulsivity by disseminating evidence-based information about health-related behaviours to families, clinicians, policy makers, and general public. We use epidemiologic approaches in the world-wide largest existing samples to investigate association of nutrition components & lifestyle with impulsivity/ compulsivity, and how such associations are moderated by age, culture, sex, SES, and genetics. We assess beneficial effects of key nutritional interventions through RCTs in highly impulsive males/females, going beyond state-of-the-art by directly comparing personalized, high-intensity approaches with one-size-fits-all and microbiome-dependent supplementations. We study the protective potential of acute exercise and habitual physical activity. We monitor intervention-induced changes in real time through objective mHealth-based experience sampling. Uniquely, we study effects of the gut-microbiome and its metabolites, as well as brain connectivity and epigenetic patterns as mediators and predictors of behavioural change. We initiate and support societal change by media-based information and education. We innovate the field by measuring behavioural change using social media downstream of educational campaigns and by translation of our findings into tangible healthy food solutions with a celebrity chef. Our group, in which experts from multiple disciplines join forces, is in a unique position to carry out the proposed project.
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Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT

Address

Geert Grooteplein Noord 9
6525 Ez Nijmegen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 3 280 171,25

Participants (17)

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STICHTING KARAKTER

Netherlands

EU Contribution

€ 1 026 598,50

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN

Germany

EU Contribution

€ 727 962

UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT

Germany

EU Contribution

€ 569 728,50

UNIVERSITAT DE BARCELONA

Spain

EU Contribution

€ 94 170

FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA

Spain

EU Contribution

€ 479 789,91

UNIVERSITETET I BERGEN

Norway

EU Contribution

€ 404 535

TARTU ULIKOOL

Estonia

EU Contribution

€ 235 425

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 955 383,75

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT

Germany

EU Contribution

€ 540 347,39

WAGENINGEN UNIVERSITY

Netherlands

EU Contribution

€ 1 293 951,25

Concentris Research Management GmbH

Germany

EU Contribution

€ 423 765

OREBRO UNIVERSITY

Sweden

EU Contribution

€ 279 331,25

SEMMELWEIS EGYETEM

Hungary

EU Contribution

€ 94 170

CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.

Spain

EU Contribution

€ 423 764,95

KARLSRUHER INSTITUT FUER TECHNOLOGIE

Germany

EU Contribution

€ 244 841,25

STICHTING BURO ECNP

Netherlands

EU Contribution

€ 23 542

ADD INFORMATION SERVICES

United Kingdom

EU Contribution

€ 47 084,76

Project information

Grant agreement ID: 728018

Status

Ongoing project

  • Start date

    1 September 2017

  • End date

    31 August 2022

Funded under:

H2020-EU.3.2.2.2.

  • Overall budget:

    € 11 148 189,76

  • EU contribution

    € 11 144 561,76

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands