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Investigating the recognition of a novel ligand by gamma-delta T cells and the translation of this interaction into molecules for future cancer immunotherapy

Project information

Grant agreement ID: 749010

Status

Closed project

  • Start date

    1 June 2017

  • End date

    31 May 2019

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 177 598,80

  • EU contribution

    € 177 598,80

Coordinated by:

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

Objective

Gamma-delta (gd-)T cells are a fast acting subset of T cells that recognize a wide variety of ligands. In contrast to alpha-beta T cells they are not restricted to classical peptide-MHC antigens. Our preliminary data on a gd-T cell clone shows selective recognition of tumour cells mediated through a novel ligand.
The aims of this action are; 1) elucidating the molecular mechanism of the gd-T cell receptor (TCR) recognizing the novel ligand on cancer cells and 2) generating therapeutic agents for cancer cells.
A multidisciplinary approach will be used to unveil the interaction of the gd-TCR with its ligand. The gd-TCR and novel ligand molecules will be made using recombinant expression. These proteins will be used to characterize this interaction in detail by determining the affinity and the crystal structure. The results generated in this part of the action will increase the current knowledge regarding gd-T cell ligands.
The researcher will reintegrate in his home country using his skills in structural immunology, which he acquired in the Rossjohn laboratory at Monash University in Australia, to address the molecular mechanism of the gd-TCR ligand interaction. Additionally, he will be trained by the host laboratory in in vitro and in vivo immunological assays.

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Address

Heidelberglaan 100
3584 Cx Utrecht

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 177 598,80

Project information

Grant agreement ID: 749010

Status

Closed project

  • Start date

    1 June 2017

  • End date

    31 May 2019

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 177 598,80

  • EU contribution

    € 177 598,80

Coordinated by:

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands