Objective Cancer remains the leading cause of disease-related death in children. For the ~25% of children who experience relapses of their malignant solid tumors, usually after very intensive first-line therapy, curative treatment options are scarce. Preclinical drug testing to identify promising treatment options that match the molecular make-up of the tumor is hampered by the facts that i) molecular genetic data on pediatric solid tumors from relapsed patients and thus our understanding of tumor evolution and therapy resistance are very limited to date and ii) for many of the high-risk entities no appropriate and molecularly well characterized patient-derived models and/or genetic mouse models are currently available. Thus, quality-assured upfront preclinical testing of novel molecularly targeted compounds in a (saturated) repertoire of well-characterized models will establish the basis to increase therapeutic successes of these drugs in children with solid malignancies. Since these tumors are overall genetically much less complex than their adult counterparts, it is anticipated that it will be easier to identify powerful predictive biomarkers to allow for accurate matching of targets and drugs.To address this high, as yet unmet clinical need, we have formed the ITCC-P4 consortium consisting of academic and commercial partners from 8 European countries and covering the full spectrum of qualifications needed for quality-assured preclinical drug development including expertise in patient derived models, histopathology, in vivo pharmacology, bioinformatics and data management, centralized testing capabilities, medical expertise regarding the entities in question, regulatory knowledge, and project management of large consortia. With this consortium in a public-private partnership with the participating pharma companies we strongly believe to be ideally positioned to greatly expedite the development of more precise and efficacious drugs for children with malignant solid tumors Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinepharmacology and pharmacypharmacokineticsmedical and health sciencesclinical medicinepaediatrics Keywords Pediatric cancer POC platform PDX GEMM biomarker relapse organoid solid tumor brain tumor Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.7. - Innovative Medicines Initiative 2 (IMI2) Topic(s) IMI2-2015-07-05 - A COMPREHENSIVE ‘PAEDIATRIC PRECLINICAL POC PLATFORM’ TO ENABLE CLINICAL MOLECULE DEVELOPMENT FOR CHILDREN WITH CANCER Call for proposal H2020-JTI-IMI2-2015-07-two-stage See other projects for this call Funding Scheme RIA - Research and Innovation action Coordinator DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Net EU contribution € 1 725 864,00 Address IM NEUENHEIMER FELD 280 69120 Heidelberg Germany See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 3 124 931,69 Participants (33) Sort alphabetically Sort by Net EU contribution Expand all Collapse all INSTITUTE OF CANCER RESEARCH: THE ROYAL CANCER HOSPITAL LBG United Kingdom Net EU contribution € 646 750,00 Address OLD BROMPTON ROAD 123 SW7 3RP London See on map Region London Inner London — West Kensington & Chelsea and Hammersmith & Fulham Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 646 750,00 INNOVATIVE THERAPIES FOR CHILDREN WITH CANCER ASSOCIATION France Net EU contribution € 107 538,00 Address RUE EDOUARD VAILLANT 114 94800 Villejuif See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 107 538,00 INSTITUT GUSTAVE ROUSSY France Net EU contribution € 380 912,00 Address Rue Camille Desmoulins 39 94805 Villejuif See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 750 912,50 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. GUSTAVE ROUSSY TRANSFERT France Net EU contribution € 120 000,00 Address 39 RUE CAMILLE DESMOULINS 94800 Villejuif See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 370 000,00 ALLEANZA CONTRO IL CANCRO Italy Net EU contribution € 27 025,00 Address VIA GIORGIO RIBOTTA 5 00144 Roma See on map Region Centro (IT) Lazio Roma Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 218 776,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. ISTITUTO ORTOPEDICO RIZZOLI Italy Net EU contribution € 118 375,00 Address VIA DI BARBIANO 1/10 40136 Bologna See on map Region Nord-Est Emilia-Romagna Bologna Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 118 375,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. OSPEDALE PEDIATRICO BAMBINO GESU Italy Net EU contribution € 26 688,00 Address PIAZZA SANT ONOFRIO 4 00165 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 26 688,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI Italy Net EU contribution € 46 688,00 Address Via Venezian 1 20133 Milan See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 46 688,00 UNIVERSITAT ZURICH Switzerland Net EU contribution € 0,00 Address RAMISTRASSE 71 8006 Zurich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 562 500,00 MEDIZINISCHE UNIVERSITAET WIEN Austria Net EU contribution € 181 075,00 Address SPITALGASSE 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 181 075,00 FUNDACIO PRIVADA PER A LA RECERCA I LA DOCENCIA SANT JOAN DE DEU Spain Net EU contribution € 264 050,00 Address SANTA ROSA 39-4 08950 Esplugues De Llobregat See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 264 050,00 EXPERIMENTELLE PHARMAKOLOGIE UND ONKOLOGIE BERLIN-BUCH GMBH Germany Net EU contribution € 668 425,00 Address ROBERT-ROESSLE-STRASSE 10 13125 Berlin See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Berlin Berlin Berlin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 213 425,00 ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands Net EU contribution € 505 300,00 Address MEIBERGDREEF 15 1105AZ Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 505 300,00 XENTECH SAS France Net EU contribution € 628 425,00 Address rue Pierre Fontaine 4 91000 Evry See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ile-de-France Ile-de-France Essonne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 128 425,00 ST ANNA KINDERKREBSFORSCHUNG VEREIN Participation ended Austria Net EU contribution € 102 811,37 Address ZIMMERMANNPLATZ 10 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 102 811,37 INSTITUT CURIE France Net EU contribution € 484 038,00 Address RUE D ULM 26 75231 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 536 781,25 CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany Net EU contribution € 467 562,00 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 467 562,50 PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV Netherlands Net EU contribution € 808 000,00 Address HEIDELBERGLAAN 25 3584CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 987 100,00 ELI LILLY AND COMPANY LTD United Kingdom Net EU contribution € 0,00 Address LILLY HOUSE BASINGVIEW RG21 4FA Basingstoke See on map Region South East (England) Hampshire and Isle of Wight North Hampshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 600 000,00 F. HOFFMANN-LA ROCHE AG Switzerland Net EU contribution € 0,00 Address GRENZACHERSTRASSE 124 4070 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 807 462,00 PFIZER LIMITED United Kingdom Net EU contribution € 0,00 Address RAMSGATE ROAD CT13 9NJ Sandwich See on map Region South East (England) Kent East Kent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 791 055,00 BAYER AKTIENGESELLSCHAFT Germany Net EU contribution € 0,00 Address KAISER-WILHELM-ALLEE 1 51373 Leverkusen See on map Region Nordrhein-Westfalen Köln Leverkusen, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 050 000,00 PHARMA MAR SA Spain Net EU contribution € 0,00 Address AVDA DE LOS REYES 1 POLIGONO INDUSTRIAL LA MINA COLMENAR VIEJO 28770 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 917 832,00 CHARLES RIVER DISCOVERY RESEARCH SERVICES GERMANY GMBH Germany Net EU contribution € 0,00 Address AM FLUGHAFEN 12-14 79108 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 427 312,00 JANSSEN PHARMACEUTICA NV Belgium Net EU contribution € 0,00 Address TURNHOUTSEWEG 30 2340 Beerse See on map Region Vlaams Gewest Prov. Antwerpen Arr. Turnhout Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 66 000,00 MARTIN-LUTHER-UNIVERSITAT HALLE-WITTENBERG Germany Net EU contribution € 0,00 Address UNIVERSITATSPLATZ 10 6108 Halle See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 42 450,00 UNIVERSITY OF NEWCASTLE UPON TYNE United Kingdom Net EU contribution € 0,00 Address KINGS GATE NE1 7RU Newcastle Upon Tyne See on map Region North East (England) Northumberland and Tyne and Wear Tyneside Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 157 500,00 ASTRAZENECA AB Sweden Net EU contribution € 0,00 Address Vastra Maelarhamnen 151 85 Sodertaelje See on map Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 20 000,00 UNIVERSITAET ULM Germany Net EU contribution € 0,00 Address HELMHOLTZSTRASSE 16 89081 Ulm See on map Region Baden-Württemberg Tübingen Ulm, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 58 450,00 AMGEN Belgium Net EU contribution € 0,00 Address TELECOMLAAN 5-7 1831 Diegem See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Halle-Vilvoorde Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 24 000,00 INSTITUT DE RECHERCHES SERVIER France Net EU contribution € 0,00 Address 3 Rue de la Republique 92150 Suresnes See on map Region Ile-de-France Ile-de-France Hauts-de-Seine Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 100 000,00 SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT France Net EU contribution € 0,00 Address 82 AVENUE RASPAIL 94250 GENTILLY See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 10 000,00 ST. ANNA KINDERKREBSFORSCHUNG GMBH Austria Net EU contribution € 60 473,63 Address ZIMMERMANNPLATZ 10 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 60 473,63
