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ITCC Pediatric Preclinical POC Platform – Sofia ref.: 116064

Objective

Cancer remains the leading cause of disease-related death in children. For the ~25% of children who experience relapses of their malignant solid tumors, usually after very intensive first-line therapy, curative treatment options are scarce. Preclinical drug testing to identify promising treatment options that match the molecular make-up of the tumor is hampered by the facts that i) molecular genetic data on pediatric solid tumors from relapsed patients and thus our understanding of tumor evolution and therapy resistance are very limited to date and ii) for many of the high-risk entities no appropriate and molecularly well characterized patient-derived models and/or genetic mouse models are currently available. Thus, quality-assured upfront preclinical testing of novel molecularly targeted compounds in a (saturated) repertoire of well-characterized models will establish the basis to increase therapeutic successes of these drugs in children with solid malignancies. Since these tumors are overall genetically much less complex than their adult counterparts, it is anticipated that it will be easier to identify powerful predictive biomarkers to allow for accurate matching of targets and drugs.

To address this high, as yet unmet clinical need, we have formed the ITCC-P4 consortium consisting of academic and commercial partners from 8 European countries and covering the full spectrum of qualifications needed for quality-assured preclinical drug development including expertise in patient derived models, histopathology, in vivo pharmacology, bioinformatics and data management, centralized testing capabilities, medical expertise regarding the entities in question, regulatory knowledge, and project management of large consortia. With this consortium in a public-private partnership with the participating pharma companies we strongly believe to be ideally positioned to greatly expedite the development of more precise and efficacious drugs for children with malignant solid tumors

Coordinator

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Net EU contribution
€ 2 700 864,00
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Germany

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Research Organisations
Non-EU contribution
€ 1 580 067,69

Participants (33)

THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
United Kingdom
Net EU contribution
€ 566 750,00
Address
Old Brompton Road 123
SW7 3RP London

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INNOVATIVE THERAPIES FOR CHILDREN WITH CANCER ASSOCIATION
France
Net EU contribution
€ 107 538,00
Address
Rue Edouard Vaillant 114
94800 Villejuif

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Region
Ile-de-France Ile-de-France Val-de-Marne
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSTITUT GUSTAVE ROUSSY
France
Net EU contribution
€ 160 912,00
Address
Rue Camille Desmoulins 39
94805 Villejuif

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Region
Ile-de-France Ile-de-France Val-de-Marne
Activity type
Research Organisations
Non-EU contribution
€ 0,50
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

GUSTAVE ROUSSY TRANSFERT
France
Net EU contribution
€ 120 000,00
Address
39 Rue Camille Desmoulins
94800 Villejuif

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Region
Ile-de-France Ile-de-France Val-de-Marne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 250 000,00
ALLEANZA CONTRO IL CANCRO
Italy
Net EU contribution
€ 27 025,00
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Italy
Net EU contribution
€ 26 688,00
Address
Via Venezian 1
20133 Milan

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Region
Nord-Ovest Lombardia Milano
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

OSPEDALE PEDIATRICO BAMBINO GESU
Italy
Net EU contribution
€ 26 688,00
Address
Piazza Sant Onofrio 4
00165 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

ISTITUTO ORTOPEDICO RIZZOLI
Italy
Net EU contribution
€ 53 375,00
Address
Via Di Barbiano 1/10
40136 Bologna

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Region
Nord-Est Emilia-Romagna Bologna
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITAT ZURICH
Switzerland
Net EU contribution
€ 0,00
Address
Ramistrasse 71
8006 Zurich

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 502 500,00
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Net EU contribution
€ 131 075,00
Address
Spitalgasse 23
1090 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FUNDACIO PRIVADA PER A LA RECERCA I LA DOCENCIA SANT JOAN DE DEU
Spain
Net EU contribution
€ 129 050,00
Address
Santa Rosa 39-4
08950 Esplugues De Llobregat

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
EXPERIMENTELLE PHARMAKOLOGIE UND ONKOLOGIE BERLIN-BUCH GMBH
Germany
Net EU contribution
€ 668 425,00
Address
Robert-roessle-strasse 10
13125 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 500 000,00
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
Net EU contribution
€ 505 300,00
Address
Meibergdreef 15
1105AZ Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
XENTECH SAS
France
Net EU contribution
€ 628 425,00
Address
Rue Pierre Fontaine 4
91000 Evry

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 500 000,00
ST ANNA KINDERKREBSFORSCHUNG VEREIN

Participation ended

Austria
Net EU contribution
€ 102 811,37
Non-EU contribution
€ 0,00
INSTITUT CURIE
France
Net EU contribution
€ 214 038,00
Address
Rue D'ulm 26
75231 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 1 052 743,25
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
Net EU contribution
€ 352 562,00
Address
Chariteplatz 1
10117 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,50
PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Netherlands
Net EU contribution
€ 788 000,00
Address
Heidelberglaan 25
3584CS Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Other
Non-EU contribution
€ 905 100,00
ELI LILLY AND COMPANY LTD
United Kingdom
Net EU contribution
€ 0,00
Address
Lilly House Basingview
RG21 4FA Basingstoke

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Region
South East (England) Hampshire and Isle of Wight North Hampshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 600 000,00
F. HOFFMANN-LA ROCHE AG
Switzerland
Net EU contribution
€ 0,00
Address
Grenzacherstrasse 124
4070 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 807 462,00
PFIZER LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Ramsgate Road
CT13 9NJ Sandwich

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Region
South East (England) Kent East Kent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 791 055,00
BAYER AKTIENGESELLSCHAFT
Germany
Net EU contribution
€ 0,00
Address
Kaiser-wilhelm-allee 1
51373 Leverkusen

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Region
Nordrhein-Westfalen Köln Leverkusen, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 300 000,00
PHARMA MAR SA
Spain
Net EU contribution
€ 0,00
Address
Avda De Los Reyes 1 Poligono Industrial La Mina Colmenar Viejo
28770 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 917 832,00
CHARLES RIVER DISCOVERY RESEARCH SERVICES GERMANY GMBH
Germany
Net EU contribution
€ 0,00
Address
Am Flughafen 12-14
79108 Freiburg

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Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 262 800,00
JANSSEN PHARMACEUTICA NV
Belgium
Net EU contribution
€ 0,00
Address
Turnhoutseweg 30
2340 Beerse

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Region
Vlaams Gewest Prov. Antwerpen Arr. Turnhout
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 66 000,00
MARTIN-LUTHER-UNIVERSITAT HALLE-WITTENBERG
Germany
Net EU contribution
€ 0,00
Address
Universitatsplatz 10
6108 Halle

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 42 450,00
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Net EU contribution
€ 0,00
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne

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Region
North East (England) Northumberland and Tyne and Wear Tyneside
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 121 500,00
ASTRAZENECA AB
Sweden
Net EU contribution
€ 0,00
Address
Vastra Maelarhamnen
151 85 Sodertaelje

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 20 000,00
UNIVERSITAET ULM
Germany
Net EU contribution
€ 0,00
Address
Helmholtzstrasse 16
89081 Ulm

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Region
Baden-Württemberg Tübingen Ulm, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 42 450,00
AMGEN
Belgium
Net EU contribution
€ 0,00
Address
Telecomlaan 5-7
1831 Diegem

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Halle-Vilvoorde
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 24 000,00
INSTITUT DE RECHERCHES SERVIER
France
Net EU contribution
€ 0,00
Address
3 Rue De La Republique
92150 Suresnes

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Region
Ile-de-France Ile-de-France Hauts-de-Seine
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 100 000,00
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
Net EU contribution
€ 0,00
Address
Pierre Brossolette 1
91380 Chilly Mazarin

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Region
Ile-de-France Ile-de-France Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 10 000,00
ST. ANNA KINDERKREBSFORSCHUNG GMBH
Austria
Net EU contribution
€ 60 473,63
Address
Zimmermannplatz 10
1090 Wien

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Region
Wien Wien
Activity type
Research Organisations
Non-EU contribution
€ 0,00