Addressing Antibiotic Resistance: New Strategies for Overcoming the ESKAPE Pathogens

Informazioni relative al progetto

NO-ESKAPE

ID dell’accordo di sovvenzione: 725523

DOI 10.3030/725523

Progetto chiuso

Data della firma CE 30 Maggio 2017

Data di avvio 1 Giugno 2017

Data di completamento 31 Maggio 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 000 000,00

Contributo UE € 2 000 000,00

Coordinato da

UNIVERSITEIT LEIDEN
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (30)

Cephalosporin Prodrug Inhibitors Overcome Metallo‐β‐Lactamase Driven Antibiotic Resistance

Autori: Matthijs J. Haren, Kamaleddin H. M. E. Tehrani, Ioli Kotsogianni, Nicola Wade, Nora C. Brüchle, Vida Mashayekhi, Nathaniel I. Martin
Pubblicato in: Chemistry – A European Journal, Numero 27/11, 2021, Pagina/e 3806-3811, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004694

Polymyxin stereochemistry and its role in antibacterial activity and outer membrane disruption

Autori: Nathaniel Martin; Angeliki Ioli Kotsogianni Teftsoglou; Charlotte Wesseling; Cornelis Jacob Slingerland
Pubblicato in: ACS Infectious Diseases, 2022, ISSN 2373-8227
Editore: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00307

Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+

Autori: David Sychantha, Caitlyn M. Rotondo, Kamaleddin H.M.E. Tehrani, Nathaniel I. Martin, Gerard D. Wright
Pubblicato in: Journal of Biological Chemistry, Numero 297/2, 2021, Pagina/e 100918, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100918

Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine.

Autori: Ross D. Ballantine; Karol Al Ayed; Samantha J. Bann; Michael Hoekstra; Nathaniel I. Martin; Stephen A. Cochrane
Pubblicato in: RSC Medicinal Chemistry, 2022, ISSN 2632-8682
Editore: Royal Society of Chemistry
DOI: 10.1039/d2md00281g

Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy

Autori: Karol Al Ayed; Ross D. Ballantine; Michael Hoekstra; Samantha J. Bann; Charlotte M. J. Wesseling; Alexander T. Bakker; Zheng Zhong; Yong-Xin Li; Nora C. Brüchle; Mario van der Stelt; Stephen A. Cochrane; Nathaniel I. Martin
Pubblicato in: Chemical Science, 2022, ISSN 2041-6539
Editore: Royal Society of Chemistry
DOI: 10.1039/d2sc00143h

Linearization of the brevicidine and laterocidine lipopeptides yields analogues that retain full antibacterial activity

Autori: Ross D. Ballantine; Karol Al Ayed; Samantha J. Bann; Michael Hoekstra; Nathaniel I. Martin; Stephen A. Cochrane
Pubblicato in: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.3c00308

Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens.

Autori: Charlotte M J Wesseling; Cornelis J Slingerland; Shanice Veraar; Samantha Lok; Nathaniel I. Martin
Pubblicato in: ACS Infectious Diseases, 2021, ISSN 2373-8227
Editore: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00466

Binding Studies Reveal Phospholipid Specificity and Its Role in the Calcium-Dependent Mechanism of Action of Daptomycin

Autori: Ioli Kotsogianni; Thomas M. Wood; Francesca M. Alexander; Stephen A. Cochrane; Nathaniel I. Martin
Pubblicato in: ACS Infectious Diseases, 2021, ISSN 2373-8227
Editore: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00316

Vancomycin-Polymyxin Nonapeptide conjugates that retain anti-Gram-positive activity with enhanced potency against Gram-negative strains

Autori: Groesen, Emma van; Slingerland, Cornelis J.; Innocenti, Paolo; Mihajlovic, Milos; Masereeuw, Rosalinde; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Afd Pharmacology; Chemical Biology and Drug Discovery; Pharmacology
Pubblicato in: ACS Infectious Diseases, 2021, ISSN 2373-8227
Editore: American Chemical Society
DOI: 10.1021/acsinfecdis.1c00318

Recent Advances in the Development of Semisynthetic Glycopeptide Antibiotics: 2014–2022

Autori: Emma van Groesen; Paolo Innocenti; Nathaniel I. Martin
Pubblicato in: ACS Infectious Diseases, 2022, ISSN 2373-8227
Editore: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00253

Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA

Autori: Bakker, A.T.; Kotsogianni, A.I.; Mirenda, L.; Straub, V.M.; Avalos Garcia, M.; Berg, R.J.B.H.N. van den; Florea, B.I.; Wezel, G.P. van; Janssen, A.P.A.; Martin, N.I.; Stelt, M. van der
Pubblicato in: Journal of the American Chemical Society, 2023, ISSN 1520-5126
Editore: American Chemical Society
DOI: 10.1021/jacs.2c10819

opening the door for gram-positive specific antibiotics

Autori: Nathaniel Martin; Charlotte Wesseling
Pubblicato in: ACS Infectious Diseases, 2022, ISSN 2373-8227
Editore: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00193

Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases

Autori: Kamaleddin H. M. E. Tehrani, Nicola Wade, Vida Mashayekhi, Nora C. Brüchle, Willem Jespers, Koen Voskuil, Diego Pesce, Matthijs J. van Haren, Gerard J. P. van Westen, Nathaniel I. Martin
Pubblicato in: Journal of Medicinal Chemistry, Numero 64/13, 2021, Pagina/e 9141-9151, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00362

Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages

Autori: Ali Javed; Cornelis J. Slingerland; Thomas M. Wood; Nathaniel I. Martin; Femke Broere; Markus H. Weingarth; Edwin J. A. Veldhuizen
Pubblicato in: ACS Infectious Diseases, 2023, ISSN 2373-8227
Editore: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00518

Metabolic labeling probes for interrogation of the host–pathogen interaction

Autori: Bob J Ignacio; Thomas Bakkum; Kimberly M. Bonger; Nathaniel I. Martin; Sander I. van Kasteren
Pubblicato in: Organic & Biomolecular Chemistry, 2021, ISSN 1477-0539
Editore: Royal Society of Chemistry
DOI: 10.1039/d0ob02517h

Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria.

Autori: Charlotte M J Wesseling; Thomas M. Wood; Thomas M. Wood; Kristine Bertheussen; Samantha Lok; Nathaniel I. Martin
Pubblicato in: Molecules, 2021, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26071954

Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition**

Autori: Nicola Wade, Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Matthijs J. Haren, Vida Mashayekhi, Nathaniel I. Martin
Pubblicato in: ChemMedChem, Numero 16/10, 2021, Pagina/e 1651-1659, ISSN 1860-7179
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202100042

Synthesis and Structure-Activity Studies of β-Barrel Assembly Machine Complex Inhibitor MRL-494.

Autori: Nicola Wade; Charlotte M. J. Wesseling; Paolo Innocenti; Cornelis J. Slingerland; Gregory M. Koningstein; Joen Luirink; Nathaniel I. Martin
Pubblicato in: ACS Infectious Diseases, 2022, ISSN 2373-8227
Editore: American Chemical Society
DOI: 10.1021/acsinfecdis.2c00459

Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures

Autori: Wood, Thomas M.; Zeronian, Matthieu R.; Buijs, Ned; Bertheussen, Kristine; Abedian, Hanieh K.; Johnson, Aidan V.; Pearce, Nicholas M.; Lutz, Martin; Kemmink, Johan; Seirsma, Tjalling; Hamoen, Leendert W.; Janssen, Bert J. C.; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Sub Structural Biochemistry; Structural Biochemistry; Pharmacology
Pubblicato in: Chemical Science, 2022, ISSN 2041-6539
Editore: Royal Society of Chemistry
DOI: 10.1039/d1sc07190d

β-lactam/β-lactamase inhibitor combinations: an update

Autori: Kamaleddin H. M. E. Tehrani, Nathaniel I. Martin
Pubblicato in: MedChemComm, Numero 9/9, 2018, Pagina/e 1439-1456, ISSN 2040-2503
Editore: Royal Society of Chemistry
DOI: 10.1039/c8md00342d

Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability

Autori: Karol Al Ayed; Denise Zamarbide Losada; Nataliia V. Machushynets; Barbara Terlouw; Somayah S. Elsayed; Julian Schill; Vincent Trebosc; Michel Pieren; Marnix H. Medema; Gilles P. van Wezel; Nathaniel I. Martin
Pubblicato in: ACS Infectious Diseases, 2023, ISSN 2373-8227
Editore: American Chemical Society
DOI: 10.1021/acsinfecdis.3c00043

A Convenient Chemoenzymatic Preparation of Chimeric Macrocyclic Peptide Antibiotics with Potent Activity against Gram-Negative Pathogens

Autori: Thomas M. Wood, Cornelis J. Slingerland, Nathaniel I. Martin
Pubblicato in: Journal of Medicinal Chemistry, Numero 64/15, 2021, Pagina/e 10890-10899, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00176

Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups

Autori: Ned Buijs, Halana C. Vlaming, Matthijs J. van Haren, Nathaniel I. Martin
Pubblicato in: ChemBioChem, 2022, ISSN 1439-7633
Editore: Wiley
DOI: 10.1002/cbic.202200547

Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids

Autori: Slingerland, Cornelis J.; Wesseling, Charlotte M. J.; Innocenti, Paolo; Westphal, Koen G. C.; Masereeuw, Rosalinde; Martin, Nathaniel I.; Afd Chemical Biology and Drug Discovery; Afd Pharmacology; Chemical Biology and Drug Discovery; Pharmacology
Pubblicato in: Journal of Medicinal Chemistry, 2022, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01528

The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry

Autori: Thomas M. Wood, Nathaniel I. Martin
Pubblicato in: MedChemComm, Numero 10/5, 2019, Pagina/e 634-646, ISSN 2040-2503
Editore: Royal Society of Chemistry
DOI: 10.1039/c9md00126c

Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine- N , N ′-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1

Autori: Kamaleddin H. M. E. Tehrani, Haigen Fu, Nora C. Brüchle, Vida Mashayekhi, Alejandro Prats Luján, Matthijs J. van Haren, Gerrit J. Poelarends, Nathaniel I. Martin
Pubblicato in: Chemical Communications, Numero 56/20, 2020, Pagina/e 3047-3049, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cc00356e

Dual targeting of the class V lanthipeptide antibiotic cacaoidin

Autori: Julia P. Deisinger; Melina Arts; Ioli Kotsogianni; Jan-Samuel Puls; Fabian Grein; Francisco Javier Ortiz-López; Nathaniel I. Martin; Anna Müller; Olga Genilloud; Tanja Schneider
Pubblicato in: iScience, 2023, ISSN 2589-0042
Editore: Cell Press
DOI: 10.1016/j.isci.2023.106394

A β-Hairpin Epitope as Novel Structural Requirement for Protein Arginine Rhamnosylation

Autori: Liubov Yakovlieva; Thomas M. Wood; Thomas M. Wood; Johan Kemmink; Ioli Kotsogianni; Franziska Koller; Juergen Lassak; Nathaniel I. Martin; Marthe T. C. Walvoort
Pubblicato in: Chemical Science, 2021, ISSN 2041-6539
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc05823h

Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem

Autori: Kamaleddin H. M. E. Tehrani, Nora C. Brüchle, Nicola Wade, Vida Mashayekhi, Diego Pesce, Matthijs J. van Haren, Nathaniel I. Martin
Pubblicato in: ACS Infectious Diseases, Numero 6/6, 2020, Pagina/e 1366-1371, ISSN 2373-8227
Editore: America Chemical Society
DOI: 10.1021/acsinfecdis.9b00459

The contribution of achiral residues in the laspartomycin family of calcium-dependent lipopeptide antibiotics

Autori: Thomas M. Wood, Kristine Bertheussen, Nathaniel I. Martin
Pubblicato in: Organic & Biomolecular Chemistry, Numero 18/3, 2020, Pagina/e 514-517, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/c9ob02534k