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Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation

Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation

Objective

Embryogenesis is achieved by the close interplay between the gene regulatory networks that control cell fate specification and the physical processes by which the embryo takes shape. While each of these systems has been extensively investigated over the past decades, comparably little is yet known about how they functionally interact across different scales of organization within the physiological context of the developing embryo. The central aim of this proposal is to elucidate the fundamental principles underlying the interaction and feedback between cell mechanics and fate specification during vertebrate gastrulation. Using zebrafish as a vertebrate model organism, we will explore how germ layer progenitor cell fate specification affects the physical processes by which the gastrula takes shape, and, vice versa, how alterations in cell/tissue mechanics feed back onto the gene regulatory networks and signals controlling progenitor cell fate specification during gastrulation. To dissect the fundamental mechanisms underlying this crosstalk, we will combine genetic, cell biological and biophysical experimentation with mathematical modeling. We expect that this transdisciplinary approach will provide answers to a central yet unresolved question in developmental biology: how the interplay between cell mechanics, dynamics and fate specification drives embryo morphogenesis and patterning.
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Host institution

INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA

Address

Am Campus 1
3400 Klosterneuburg

Austria

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 306 862

Beneficiaries (1)

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INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA

Austria

EU Contribution

€ 2 306 862

Project information

Grant agreement ID: 742573

Status

Ongoing project

  • Start date

    1 July 2017

  • End date

    30 June 2022

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 2 306 862

  • EU contribution

    € 2 306 862

Hosted by:

INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA

Austria