CORDIS
EU research results

CORDIS

English EN
ImmortaSTEM: Transient Immortalisation for Patient Stem Cell Expansion and Therapeutic Application

ImmortaSTEM: Transient Immortalisation for Patient Stem Cell Expansion and Therapeutic Application

Objective

Under an ERC Advanced Grant, and subsequent PoC grant, Professor Shakesheff's team have invented a new intracellular delivery system that overcomes a problem in drug delivery in stem cell culture as well as regenerative medicine and other therapeutic approaches. The system, called GAG-binding enhanced transduction (GET), enables intracellular delivery of proteins, nucleic acids and particles into cells that resist other non-viral strategies. The work under ERC Advanced Grant and PoC funding has allowed exemplification of the delivery of proteins that promote pluripotency or differentiation, and delivery and expression of mRNA

This ImmortaSTEM: Proof-of-Concept Application will achieve 7 deliverables that together will generate a robust business plan for commercialisation of a specific application of GET to aid cell therapy attempts. This is a unique approach allowing expansion of a patient’s own cells as a therapy. We will begin by performing a comprehensive market analysis to test our view that GET could be used to expand valuable cells presently defined as challenging or impossible. Next we take account of the market analysis to refine our technical work resulting in a report that provides robust evidence of market required advantages of GET over competitor products for stem cell expansion. This technical work will include a consideration of manufacturing routes and costs of goods. In parallel with the technical work we will commission an independent freedom-to-operate report. Finally, we will initiate confidential discussions with potential partners and customers via face-to-face meetings in Europe and the US.

The final business plan will establish the technical and commercial feasibility of our approaches in one or more of our target markets. We envisage that at the end of the ERC PoC grant we will attract substantial funding to rapidly progress product launches and licenses with significant impact on the regenerative medicine and cell therapy sectors.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Host institution

THE UNIVERSITY OF NOTTINGHAM

Address

University Park
Ng7 2rd Nottingham

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 149 932

Beneficiaries (1)

Sort alphabetically

Sort by EU Contribution

Expand all

THE UNIVERSITY OF NOTTINGHAM

United Kingdom

EU Contribution

€ 149 932

Project information

Grant agreement ID: 754745

Status

Closed project

  • Start date

    1 July 2017

  • End date

    31 December 2018

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 149 932

  • EU contribution

    € 149 932

Hosted by:

THE UNIVERSITY OF NOTTINGHAM

United Kingdom