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Big Data 4 Better Hearts - Sofia ref.: 116074

Periodic Reporting for period 4 - BigData Heart (Big Data 4 Better Hearts - Sofia ref.: 116074)

Reporting period: 2020-03-01 to 2021-02-28

Launched in March 2017, BigData@Heart is a five-year project consisting of patient networks, learned societies, SMEs, pharmaceutical companies and academia.

The project is dealing with a changing health care landscape, where the sustainability and quality of health care provision in Europe is being challenged. Demographic change and rapid innovation are leading to inconsistent medical care across Europe. Despite remarkable progress in the management of the most common cardiovascular diseases (CVDs) in Europe today, namely, acute coronary syndrome (ACS), atrial fibrillation (AF), and heart failure (HF), their disease burden remains high. Optimal management of these conditions is complicated by their complex etiologies, poor definition at the molecular level, and the added burden of co-/multi-morbidities.

This leads to unpredictable and large variation in interindividual therapeutic response, heterogeneous prognoses, and treatment guidelines that are based on conventional risk factors and clinical markers of end-organ damage. These barriers pose major problems in the development and delivery of targeted CVD treatments. The aim of BigData@Heart is to apply big data approaches to ACS, AF and HF in the hope to improve patient outcomes. Bringing together key stakeholders in the field of CVDs, BigData@Heart’s ultimate goal is to address the challenges outlined above by developing a big data-driven translational research platform of unparalleled scale and phenotypic resolution. The research platform will deliver clinically relevant disease phenotypes, scalable insights from real-world evidence driving drug development and personalized medicine through advanced analytics.
WP1 Project management
The project governance structure is fully operational and progress and risks are being monitored with relevant tools. An Editorial Board was set up to coordinate the papers planned by the consortium to suggest and strengthen collaborations between (public and industry) partners and ultimately plan communication activities for these publications in collaboration with WP6. Currently 43 peer-reviewed articles have been published.

WP2 Disease understanding and outcomes definition
WP2 is working on research on data-driven phenotypes and further approval for the use of the larger CALIBER and ABUCASIS datasets has been granted. Two stakeholder meetings with representation from industry, patient organisations, HTA, regulators and payers have been organised. As a results. checklist for EHR studies has been suggested and will be published soon.
A globally agreed AF Standard Set of Outcomes and electronic health record codes for all variables have been incorporated. It will enable measurement and comparison of important outcomes in a consistent manner with other countries around the world.

WP3 Data sources
WP3 has completed the search strategy and literature review of contemporary data sources for HF, ACS and AF and the findings will be published in a research paper in the coming period.
The BigData@Heart community on the EMIF platform has been created as an open access catalogue detailing the available datasets and associated variables in the consortium. The fingerprint template has been completed for multiple datasets and the fingerprint template for CALIBER has also been published. We are working to get the fingerprints of the above-mentioned literature review published in the EMIF catalogue.
Multiple mapping workshops with data owners have taken place and the CALIBER and ABUCASIS datasets have been mapped to the OMOP common data model. UK biobank is currently being mapped.
Furthermore, the RADAR-base platform is now being used to study patients with AF. The University of Birmingham is conducting a year-long study as part of the follow-up phase of the RAte control Therapy Evaluation in permanent Atrial Fibrillation (RATE-AF) trial.

WP4 Enrichment with Omics
WP4 has been working on the systematic evaluation of principles and opportunities of data enrichment strategies. Reflecting a new focus on enrichment with analysis, WP4 has initiated a consortium-wide HF phenotype group to deliver validated and definitions disease outcomes and covariates relevant to HF across the consortium. An enrichment project has been conducted in collaboration with the industry partner SomaLogic and the third party Erasmus University of Rotterdam.

WP5 Data analysis
Working groups have been established between different partners within WP5, as well as close links with other WPs and case studies to maximize synergy and resources and ensure coherent output at the end of the project. Industry data sets have been shared with the consortium and have been used for analysis in a case study. A paper on this work is in preparation. Several work package overarching case studies are in progress, some with shared data from industry. A prospective data set from Novartis is currently being negotiated to be shared with the academic partners of the consortium.

WP6 Communications of results and guidance documents
WP6 has been working on raising further awareness for the BigData@Heart project and increase dissemination of outputs. Different communication activities have been undertaken in the third year: the project results were disseminated in several conferences, publishing external newsletters, social media presence on Twitter and interviews with key scientific work package leads in the consortium. Webinars were organised to communicate information and results of the projects.

WP7 Ethics and data privacy
An agreement has been reached by the consortium on the final decision making procedure regarding data access and sharing and via a webinar the related report and outcomes have been disseminated. A paper on „Patients and public views and attitudes towards the sharing of health data for research“ was published (DOI: http://dx.doi.org/10.1136/medethics-2019-105651).
It is the first time that consented cohorts, electronic health records in population settings, disease quality improvement registries, trial data, and clinically recorded imaging data will be studied together to identify mismatches and deliver novel disease vocabulary and outcome definitions in the cardiovascular realm in Europe. This new vocabulary should assist the development of new medications, interventions, and targeted management recommendations that improve patient outcomes. BigData@Heart’s ambition is to translate these new findings into universal definitions for ACS, AF, and HF. This will impact clinical trial design and contribute in the transition of economically feasible personalized medicine.

More specific, the expected impact of BigData@Heart on science, industry, policies and the patient population includes: 1) definitions of disease and outcome that are universal, computable, and relevant for patients, clinicians, industry and regulators, 2) informatics platforms that link, visualise and harmonise data sources of varying types, completeness and structure, 3) data science techniques to develop new definitions of disease, identify new phenotypes, and construct personalized predictive models, and 4) guidelines that allow for cross-border usage of big data sources acknowledging ethical and legal constraints as well as data security. Achieving this impact is driven by the structured approach that safeguards the involvement of all key stakeholders and the wide dissemination and swift implementation of project results.
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