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Capillary systems for advanced point-of-care diagnostics

Capillary systems for advanced point-of-care diagnostics

Objective

"The worldwide in vitro diagnostic (IVD) is continually growing. At least 36% of the IVD market comprises point-of-care (POC)
tests, which are performed by healthcare professional in various settings or by patients themselves. A large number of
companies entered the POC testing market in the recent years while bringing significant technological improvements and
novel concepts to this market. Yet, many important needs for immunodiagnostics are unmet: POC tests still require relatively
large volumes of samples, cannot readily be multiplexed, are not always accurate, and often involve simple liquid
displacement ""from point A to point B"" with minimal control over the distribution of reagents and kinetics of reactions.

Here, we propose a synergistic project aiming at developing simple-to-use and high-performance microfluidic capillary
systems (""CAPSYS"") for POC testing. Each part of the project will correspond to a complete PhD work with specific skills,
methodology, and know-how from the academic and industrial PIs. The common theme for both projects will be the use of
capillary forces for the autonomous filling of microfluidics by samples and liquids and the integration of reagents and
receptors for analyte detection inside the microfluidic chips. Those microfluidic chips will allow 1-step assays, i.e. assays
wherein a non-technical user only needs to load a sample to the chip for performing a biological test.

CAPSYS will lead to a new state of the art in terms of POC testing with significant relevance in medicine and diagnostics.
CAPSYS will therefore be ideal for early stage researchers (ESRs) in terms of learning various disciplines in depth, creating
numerous opportunities for publishing, and working on problem-oriented research that can have an impact in the ""real
world""."
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Coordinator

KARLSRUHER INSTITUT FUER TECHNOLOGIE

Address

Kaiserstrasse 12
76131 Karlsruhe

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 235 371,12

Participants (1)

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IBM RESEARCH GMBH

Switzerland

EU Contribution

€ 279 961,58

Project information

Grant agreement ID: 764476

Status

Ongoing project

  • Start date

    1 January 2018

  • End date

    31 December 2021

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 515 332,70

  • EU contribution

    € 515 332,70

Coordinated by:

KARLSRUHER INSTITUT FUER TECHNOLOGIE

Germany