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Synthetic Circuits for Robust Orthogonal Production

Objective

The repertoire of industrially produced fine chemicals in various biological systems will rapidly expand using the tools from the emerging field of synthetic biology. However, the high-level production of non-natural products or de novo activities through synthetic circuits compromises the integrity of host organisms, which significantly impacts or even prevents the development of an industrial pipeline. Our ability to exploit the potential of synthetic biology for industrial production is constrained by our understanding of the integrated cell response when introducing a new synthetic circuit into the homeostatic network of the cell. SynCrop’s main goal is to establish a European Training Network that merges the fragmented scientific expertise in theoretical, experimental and application-driven quantitative biology to educate the next generation of researchers to construct modular and tunable synthetic circuits and foster the development of novel production platforms for food additives (e.g. vitamins, carotenoids and exopolysaccharides). Researchers with inter-disciplinary skills in both experimental and computational biology are needed to solve complex application-driven problems. SynCrop brings together ten academic partners from quantitative biology, cell engineering, microbial physiology and mathematical modelling fields and six industrial partners, including key experts in metabolic engineering and industrial biotechnology. The consortium will provide 15 early-stage researchers with cutting-edge multi-disciplinary research training, through tailored research projects, rigorous exchange of expertise among researchers and partners, and participation in specialised courses, workshops and conferences augmented by extensive training in complementary skills. SynCrop will generate a strong cohort of highly-employable scientists with unique inter-disciplinary and intersectoral skills to address complex questions and develop innovative biotechnological processes.

Coordinator

UNIVERSITAET HAMBURG

Address

Mittelweg 177
20148 Hamburg

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 498 432,96

Participants (11)

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BIOSYNTIA APS

Denmark

EU Contribution

€ 290 081,88

CHALMERS TEKNISKA HOEGSKOLA AB

Sweden

EU Contribution

€ 263 659,32

CHR. HANSEN A/S

Denmark

EU Contribution

€ 290 081,88

DSM FOOD SPECIALTIES BV

Netherlands

EU Contribution

€ 255 374,28

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 265 226,76

STICHTING VU

Netherlands

EU Contribution

€ 255 374,28

TECHNISCHE UNIVERSITAT BERLIN

Germany

EU Contribution

€ 249 216,48

THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN

United Kingdom

EU Contribution

€ 273 287,88

THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 546 575,76

RIJKSUNIVERSITEIT GRONINGEN

Netherlands

EU Contribution

€ 510 748,56

UNIVERSITY OF YORK

United Kingdom

EU Contribution

€ 273 287,88

Partners (4)

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BIOFACTION KG

INSILICO BIOTECHNOLOGY AG

LANTHIOPEP BV

UNIVERSITY OF BRISTOL

Project information

Grant agreement ID: 764591

Status

Ongoing project

  • Start date

    1 January 2018

  • End date

    31 December 2021

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 971 347,92

  • EU contribution

    € 3 971 347,92

Coordinated by:

UNIVERSITAET HAMBURG

Germany