Objective
Essential role of protein modification by members of the Ubiquitin family: Post-translational modifications (PTM) by members of the Ubiquitin (Ub) family represent an efficient way to regulate protein function at several levels: to change their localisation, activity, their interaction with partner proteins or their stability at the right time and cellular compartment, according to the cell requirements. Defects in this homeostatic equilibrium result in pathologies such as cancer, neurodegeneration, inflammation or multiple infections. For this reason, this research area has become very attractive for fundamental scientists as well as for the pharmaceutical industry aiming to identify potential targets for therapeutic intervention. Ub family members hold a homeostatic equilibrium within the cell and are interconnected in various ways including the regulation of enzymes that control the modified status of target proteins. Interestingly, Ub and Ub-like (UbL) proteins can modify themselves, forming intricate and complex chains. This landscape has recently expanded with the discovery of the formation of heterologous chains among UbL molecules including SUMO or NEDD8 but also other PTMs such as phosphorylation or acetylation. This unsuspected complexity of what is now known as the «Ubiquitin Code», which is an unknown universal language that needs to be deciphered to understand protein homeostasis and its associated pathologies. To decrypt this complex code requires joint collaborative multidisciplinary efforts at all levels, including the use of distinct molecular systems and model organisms and the latest technological developments to explore chemical, biochemical, molecular, pharmacological and clinical aspects of protein modification by members of the Ub family. UbiCODE represents an unprecedented effort to understand this code in an integrated manner.
Field of science
- /medical and health sciences/basic medicine/pathology
- /natural sciences/biological sciences/biochemistry/biomolecules/proteins
Programme(s)
Call for proposal
H2020-MSCA-ITN-2017
See other projects for this call
Funding Scheme
MSCA-ITN-ETN - European Training Networks











Coordinator
75794 Paris
France
Participants (10)
80539 Muenchen
2333 ZA Leiden
4058 Basel
L69 7ZX Liverpool
48160 Derio Vizcaya
Participation ended
SN2 1FL Swindon
60323 Frankfurt Am Main
55128 Mainz
DD1 4HN Dundee
2880 Bagsvaerd
Partners (9)
Leioa
Lisboa
75014 Paris
Basel
1066CX Amsterdam
1017BT Amsterdam
Cambridge
DD1 5EH Dundee
64293 Darmstadt