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European Research Training to Decipher The Ub Code : identification of potential biomarkers and drug targets

European Research Training to Decipher The Ub Code : identification of potential biomarkers and drug targets

Objective

Essential role of protein modification by members of the Ubiquitin family: Post-translational modifications (PTM) by members of the Ubiquitin (Ub) family represent an efficient way to regulate protein function at several levels: to change their localisation, activity, their interaction with partner proteins or their stability at the right time and cellular compartment, according to the cell requirements. Defects in this homeostatic equilibrium result in pathologies such as cancer, neurodegeneration, inflammation or multiple infections. For this reason, this research area has become very attractive for fundamental scientists as well as for the pharmaceutical industry aiming to identify potential targets for therapeutic intervention. Ub family members hold a homeostatic equilibrium within the cell and are interconnected in various ways including the regulation of enzymes that control the modified status of target proteins. Interestingly, Ub and Ub-like (UbL) proteins can modify themselves, forming intricate and complex chains. This landscape has recently expanded with the discovery of the formation of heterologous chains among UbL molecules including SUMO or NEDD8 but also other PTMs such as phosphorylation or acetylation. This unsuspected complexity of what is now known as the «Ubiquitin Code», which is an unknown universal language that needs to be deciphered to understand protein homeostasis and its associated pathologies. To decrypt this complex code requires joint collaborative multidisciplinary efforts at all levels, including the use of distinct molecular systems and model organisms and the latest technological developments to explore chemical, biochemical, molecular, pharmacological and clinical aspects of protein modification by members of the Ub family. UbiCODE represents an unprecedented effort to understand this code in an integrated manner.
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Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Address

Rue Michel Ange 3
75794 Paris

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 525 751,20

Participants (10)

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MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 249 216,48

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 510 748,56

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION

Switzerland

EU Contribution

€ 265 226,76

THE UNIVERSITY OF LIVERPOOL

United Kingdom

EU Contribution

€ 273 287,88

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS

Spain

EU Contribution

€ 247 872,96

MEDICAL RESEARCH COUNCIL

United Kingdom

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN

Germany

EU Contribution

€ 249 216,48

INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH

Germany

EU Contribution

€ 249 216,48

UNIVERSITY OF DUNDEE

United Kingdom

EU Contribution

€ 546 575,76

NOVO NORDISK A/S

Denmark

EU Contribution

€ 290 081,88

Partners (9)

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Basque Country University

Nova Medical School

Hybrigenics

Novartis

UbiQ

Yellow Research B.V.

The Naked Scientists Ltd

Ubiquigent Ltd

MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN

Project information

Grant agreement ID: 765445

Status

Ongoing project

  • Start date

    1 January 2018

  • End date

    31 December 2021

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 407 194,44

  • EU contribution

    € 3 407 194,44

Coordinated by:

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France