Skip to main content

European Research Training to Decipher The Ub Code : identification of potential biomarkers and drug targets

Objective

Essential role of protein modification by members of the Ubiquitin family: Post-translational modifications (PTM) by members of the Ubiquitin (Ub) family represent an efficient way to regulate protein function at several levels: to change their localisation, activity, their interaction with partner proteins or their stability at the right time and cellular compartment, according to the cell requirements. Defects in this homeostatic equilibrium result in pathologies such as cancer, neurodegeneration, inflammation or multiple infections. For this reason, this research area has become very attractive for fundamental scientists as well as for the pharmaceutical industry aiming to identify potential targets for therapeutic intervention. Ub family members hold a homeostatic equilibrium within the cell and are interconnected in various ways including the regulation of enzymes that control the modified status of target proteins. Interestingly, Ub and Ub-like (UbL) proteins can modify themselves, forming intricate and complex chains. This landscape has recently expanded with the discovery of the formation of heterologous chains among UbL molecules including SUMO or NEDD8 but also other PTMs such as phosphorylation or acetylation. This unsuspected complexity of what is now known as the «Ubiquitin Code», which is an unknown universal language that needs to be deciphered to understand protein homeostasis and its associated pathologies. To decrypt this complex code requires joint collaborative multidisciplinary efforts at all levels, including the use of distinct molecular systems and model organisms and the latest technological developments to explore chemical, biochemical, molecular, pharmacological and clinical aspects of protein modification by members of the Ub family. UbiCODE represents an unprecedented effort to understand this code in an integrated manner.

Field of science

  • /medical and health sciences/basic medicine/pathology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins

Call for proposal

H2020-MSCA-ITN-2017
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Address
Rue Michel Ange 3
75794 Paris
France
Activity type
Research Organisations
EU contribution
€ 525 751,20

Participants (10)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 249 216,48
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 510 748,56
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland
EU contribution
€ 265 226,76
Address
Maulbeerstrasse 66
4058 Basel
Activity type
Research Organisations
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 273 287,88
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain
EU contribution
€ 247 872,96
Address
Parque Tecnologico Edificio 801 A
48160 Derio Vizcaya
Activity type
Research Organisations
UNITED KINGDOM RESEARCH AND INNOVATION

Participation ended

United Kingdom
EU contribution
€ 0
Address
Polaris House North Star Avenue
SN2 1FL Swindon
Activity type
Research Organisations
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
EU contribution
€ 249 216,48
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH
Germany
EU contribution
€ 249 216,48
Address
Ackermannweg 4
55128 Mainz
Activity type
Research Organisations
UNIVERSITY OF DUNDEE
United Kingdom
EU contribution
€ 546 575,76
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
NOVO NORDISK A/S
Denmark
EU contribution
€ 290 081,88
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (9)

Basque Country University
Spain
Address

Leioa
Activity type
Higher or Secondary Education Establishments
Nova Medical School
Portugal
Address

Lisboa
Activity type
Higher or Secondary Education Establishments
HYBRIGENICS SA
France
Address
Impasse Reille 3-5
75014 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Novartis
Switzerland
Address

Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UBIQ BIO BV
Netherlands
Address
Plesmanlaan 121
1066CX Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
YELLOW RESEARCH
Netherlands
Address
Herengracht 495
1017BT Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
The Naked Scientists Ltd
United Kingdom
Address

Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Ubiquigent Ltd
United Kingdom
Address
James Black Centre, Dow Street
DD1 5EH Dundee
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN
Germany
Address
Frankfurter Strasse 250
64293 Darmstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)